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Antioxidant and angiostatic effect of Spirulina platensis suspension in complete Freund's adjuvant-induced arthritis in rats.

Ali EA, Barakat BM, Hassan R - PLoS ONE (2015)

Bottom Line: Spirulina treated group showed a higher survival rate and moreover, it reduced the clinical score of RA in a dose dependent manner.Furthermore, Spirulina decreased serum levels of COX-2, TNF-α, IL-6, TBARS, VEGF and increased serum levels of GSH compared to the RA non-treated group.The suppressing effect of Spirulina could be attributed, at least in part, to anti-inflammatory, antioxidant and anti-angiogenic properties.

View Article: PubMed Central - PubMed

Affiliation: Department of Histology & Cell Biology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.

ABSTRACT

Background: Currently, natural products have built a well-recognized role in the management of many degenerative diseases, mainly rheumatoid arthritis. Recent studies suggest that Spirulina, a unicellular blue-green alga, may have a variety of health benefits and curative properties and is also competent of acting as an anti-inflammatory, antioxidant and recently anti-angiogenic agent. In the present study, the antioxidant and the immunomodulatory effect of Spirulina platensis as well as its anti-angiogenic effect against complete Freund's adjuvant-induced arthritis (AIA) in rat model were tested.

Results: We found that the development of arthritis was concealed; moreover it successfully inhibited the development of macroscopic as well as microscopic and histopathological lesions in AIA rats when compared to control. Spirulina treated group showed a higher survival rate and moreover, it reduced the clinical score of RA in a dose dependent manner. Furthermore, Spirulina decreased serum levels of COX-2, TNF-α, IL-6, TBARS, VEGF and increased serum levels of GSH compared to the RA non-treated group.

Conclusions: The present study concluded that Spirulina is able to restrain the changes produced through adjuvant-induced arthritis. The suppressing effect of Spirulina could be attributed, at least in part, to anti-inflammatory, antioxidant and anti-angiogenic properties.

No MeSH data available.


Related in: MedlinePlus

Effect of Spirulina (200 or 400 mg/kg) vs. indomethacin on serum level of TNF-α (A), IL-6 (B), COX-2 (C) and VEGF (D).Data are presented as mean ± SEM. *Compared to vehicle, #Compared to CFA control, @Compared to indomethacin, $Compared to Spirulina (200 mg/kg), n = 5–6.
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pone.0121523.g002: Effect of Spirulina (200 or 400 mg/kg) vs. indomethacin on serum level of TNF-α (A), IL-6 (B), COX-2 (C) and VEGF (D).Data are presented as mean ± SEM. *Compared to vehicle, #Compared to CFA control, @Compared to indomethacin, $Compared to Spirulina (200 mg/kg), n = 5–6.

Mentions: The current results demonstrated that serum level of TNF-α, IL-6, COX 2 and VEGF were greater in AIA control group in comparison to the vehicle group. Treatment with indomethacin lessened serum TNF-α, IL-6 and VEGF level without effect on serum COX 2. However Spirulina (200 or 400 mg/kg) reduced all these markers compared to AIA control group without difference with respect to indomethacin group (P<0.05, Fig 2).


Antioxidant and angiostatic effect of Spirulina platensis suspension in complete Freund's adjuvant-induced arthritis in rats.

Ali EA, Barakat BM, Hassan R - PLoS ONE (2015)

Effect of Spirulina (200 or 400 mg/kg) vs. indomethacin on serum level of TNF-α (A), IL-6 (B), COX-2 (C) and VEGF (D).Data are presented as mean ± SEM. *Compared to vehicle, #Compared to CFA control, @Compared to indomethacin, $Compared to Spirulina (200 mg/kg), n = 5–6.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4390336&req=5

pone.0121523.g002: Effect of Spirulina (200 or 400 mg/kg) vs. indomethacin on serum level of TNF-α (A), IL-6 (B), COX-2 (C) and VEGF (D).Data are presented as mean ± SEM. *Compared to vehicle, #Compared to CFA control, @Compared to indomethacin, $Compared to Spirulina (200 mg/kg), n = 5–6.
Mentions: The current results demonstrated that serum level of TNF-α, IL-6, COX 2 and VEGF were greater in AIA control group in comparison to the vehicle group. Treatment with indomethacin lessened serum TNF-α, IL-6 and VEGF level without effect on serum COX 2. However Spirulina (200 or 400 mg/kg) reduced all these markers compared to AIA control group without difference with respect to indomethacin group (P<0.05, Fig 2).

Bottom Line: Spirulina treated group showed a higher survival rate and moreover, it reduced the clinical score of RA in a dose dependent manner.Furthermore, Spirulina decreased serum levels of COX-2, TNF-α, IL-6, TBARS, VEGF and increased serum levels of GSH compared to the RA non-treated group.The suppressing effect of Spirulina could be attributed, at least in part, to anti-inflammatory, antioxidant and anti-angiogenic properties.

View Article: PubMed Central - PubMed

Affiliation: Department of Histology & Cell Biology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.

ABSTRACT

Background: Currently, natural products have built a well-recognized role in the management of many degenerative diseases, mainly rheumatoid arthritis. Recent studies suggest that Spirulina, a unicellular blue-green alga, may have a variety of health benefits and curative properties and is also competent of acting as an anti-inflammatory, antioxidant and recently anti-angiogenic agent. In the present study, the antioxidant and the immunomodulatory effect of Spirulina platensis as well as its anti-angiogenic effect against complete Freund's adjuvant-induced arthritis (AIA) in rat model were tested.

Results: We found that the development of arthritis was concealed; moreover it successfully inhibited the development of macroscopic as well as microscopic and histopathological lesions in AIA rats when compared to control. Spirulina treated group showed a higher survival rate and moreover, it reduced the clinical score of RA in a dose dependent manner. Furthermore, Spirulina decreased serum levels of COX-2, TNF-α, IL-6, TBARS, VEGF and increased serum levels of GSH compared to the RA non-treated group.

Conclusions: The present study concluded that Spirulina is able to restrain the changes produced through adjuvant-induced arthritis. The suppressing effect of Spirulina could be attributed, at least in part, to anti-inflammatory, antioxidant and anti-angiogenic properties.

No MeSH data available.


Related in: MedlinePlus