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Antioxidant and angiostatic effect of Spirulina platensis suspension in complete Freund's adjuvant-induced arthritis in rats.

Ali EA, Barakat BM, Hassan R - PLoS ONE (2015)

Bottom Line: Spirulina treated group showed a higher survival rate and moreover, it reduced the clinical score of RA in a dose dependent manner.Furthermore, Spirulina decreased serum levels of COX-2, TNF-α, IL-6, TBARS, VEGF and increased serum levels of GSH compared to the RA non-treated group.The suppressing effect of Spirulina could be attributed, at least in part, to anti-inflammatory, antioxidant and anti-angiogenic properties.

View Article: PubMed Central - PubMed

Affiliation: Department of Histology & Cell Biology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.

ABSTRACT

Background: Currently, natural products have built a well-recognized role in the management of many degenerative diseases, mainly rheumatoid arthritis. Recent studies suggest that Spirulina, a unicellular blue-green alga, may have a variety of health benefits and curative properties and is also competent of acting as an anti-inflammatory, antioxidant and recently anti-angiogenic agent. In the present study, the antioxidant and the immunomodulatory effect of Spirulina platensis as well as its anti-angiogenic effect against complete Freund's adjuvant-induced arthritis (AIA) in rat model were tested.

Results: We found that the development of arthritis was concealed; moreover it successfully inhibited the development of macroscopic as well as microscopic and histopathological lesions in AIA rats when compared to control. Spirulina treated group showed a higher survival rate and moreover, it reduced the clinical score of RA in a dose dependent manner. Furthermore, Spirulina decreased serum levels of COX-2, TNF-α, IL-6, TBARS, VEGF and increased serum levels of GSH compared to the RA non-treated group.

Conclusions: The present study concluded that Spirulina is able to restrain the changes produced through adjuvant-induced arthritis. The suppressing effect of Spirulina could be attributed, at least in part, to anti-inflammatory, antioxidant and anti-angiogenic properties.

No MeSH data available.


Related in: MedlinePlus

Mortality in the experimental groups by Fisher's Exact Test, * p value = 0.2 # p value = 1.0(a).(b) Effect of Spirulina (200 or 400 mg/kg) vs. indomethacin on the clinical score of the ankles, P<0.001 (Kruskal Wallis Test was statistically significant at 95% confidence level). (c) Effect of Spirulina (200 or 400 mg/kg) vs. indomethacin on the serum TBARS level. (d) Effect of Spirulina (200 or 400 mg/kg) vs. indomethacin on serum GSH level. *Compared to vehicle, #Compared to AIA control, @Compared to indomethacin, $Compared to Spirulina (200 mg/kg), n = 5–6.
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pone.0121523.g001: Mortality in the experimental groups by Fisher's Exact Test, * p value = 0.2 # p value = 1.0(a).(b) Effect of Spirulina (200 or 400 mg/kg) vs. indomethacin on the clinical score of the ankles, P<0.001 (Kruskal Wallis Test was statistically significant at 95% confidence level). (c) Effect of Spirulina (200 or 400 mg/kg) vs. indomethacin on the serum TBARS level. (d) Effect of Spirulina (200 or 400 mg/kg) vs. indomethacin on serum GSH level. *Compared to vehicle, #Compared to AIA control, @Compared to indomethacin, $Compared to Spirulina (200 mg/kg), n = 5–6.

Mentions: The results of the present study indicated that the vehicle group, AIA control and Spirulina (400 mg/Kg) groups did not show mortalities during the course of the experiment. However, when comparing mortality in indomethacin and Spirulina (200 mg/Kg) groups with the vehicle group, Iindomethacin group showed 37.5% mortality while in Spirulina (200 mg/Kg) group it was 12.5% andthis was insignificantly different from the vehicle group (P = 0.2 and 1.0 respectively) (Fig 1a).


Antioxidant and angiostatic effect of Spirulina platensis suspension in complete Freund's adjuvant-induced arthritis in rats.

Ali EA, Barakat BM, Hassan R - PLoS ONE (2015)

Mortality in the experimental groups by Fisher's Exact Test, * p value = 0.2 # p value = 1.0(a).(b) Effect of Spirulina (200 or 400 mg/kg) vs. indomethacin on the clinical score of the ankles, P<0.001 (Kruskal Wallis Test was statistically significant at 95% confidence level). (c) Effect of Spirulina (200 or 400 mg/kg) vs. indomethacin on the serum TBARS level. (d) Effect of Spirulina (200 or 400 mg/kg) vs. indomethacin on serum GSH level. *Compared to vehicle, #Compared to AIA control, @Compared to indomethacin, $Compared to Spirulina (200 mg/kg), n = 5–6.
© Copyright Policy
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC4390336&req=5

pone.0121523.g001: Mortality in the experimental groups by Fisher's Exact Test, * p value = 0.2 # p value = 1.0(a).(b) Effect of Spirulina (200 or 400 mg/kg) vs. indomethacin on the clinical score of the ankles, P<0.001 (Kruskal Wallis Test was statistically significant at 95% confidence level). (c) Effect of Spirulina (200 or 400 mg/kg) vs. indomethacin on the serum TBARS level. (d) Effect of Spirulina (200 or 400 mg/kg) vs. indomethacin on serum GSH level. *Compared to vehicle, #Compared to AIA control, @Compared to indomethacin, $Compared to Spirulina (200 mg/kg), n = 5–6.
Mentions: The results of the present study indicated that the vehicle group, AIA control and Spirulina (400 mg/Kg) groups did not show mortalities during the course of the experiment. However, when comparing mortality in indomethacin and Spirulina (200 mg/Kg) groups with the vehicle group, Iindomethacin group showed 37.5% mortality while in Spirulina (200 mg/Kg) group it was 12.5% andthis was insignificantly different from the vehicle group (P = 0.2 and 1.0 respectively) (Fig 1a).

Bottom Line: Spirulina treated group showed a higher survival rate and moreover, it reduced the clinical score of RA in a dose dependent manner.Furthermore, Spirulina decreased serum levels of COX-2, TNF-α, IL-6, TBARS, VEGF and increased serum levels of GSH compared to the RA non-treated group.The suppressing effect of Spirulina could be attributed, at least in part, to anti-inflammatory, antioxidant and anti-angiogenic properties.

View Article: PubMed Central - PubMed

Affiliation: Department of Histology & Cell Biology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.

ABSTRACT

Background: Currently, natural products have built a well-recognized role in the management of many degenerative diseases, mainly rheumatoid arthritis. Recent studies suggest that Spirulina, a unicellular blue-green alga, may have a variety of health benefits and curative properties and is also competent of acting as an anti-inflammatory, antioxidant and recently anti-angiogenic agent. In the present study, the antioxidant and the immunomodulatory effect of Spirulina platensis as well as its anti-angiogenic effect against complete Freund's adjuvant-induced arthritis (AIA) in rat model were tested.

Results: We found that the development of arthritis was concealed; moreover it successfully inhibited the development of macroscopic as well as microscopic and histopathological lesions in AIA rats when compared to control. Spirulina treated group showed a higher survival rate and moreover, it reduced the clinical score of RA in a dose dependent manner. Furthermore, Spirulina decreased serum levels of COX-2, TNF-α, IL-6, TBARS, VEGF and increased serum levels of GSH compared to the RA non-treated group.

Conclusions: The present study concluded that Spirulina is able to restrain the changes produced through adjuvant-induced arthritis. The suppressing effect of Spirulina could be attributed, at least in part, to anti-inflammatory, antioxidant and anti-angiogenic properties.

No MeSH data available.


Related in: MedlinePlus