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Interstitial fluid colloid osmotic pressure in healthy children.

Guthe HJ, Indrebø M, Nedrebø T, Norgård G, Wiig H, Berg A - PLoS ONE (2015)

Bottom Line: Arbitrary division of children in four different age groups, showed no significant difference in plasma or interstitial fluid COP values for patients less than 8 years, whereas patients of 8-10 years had significant higher COP both in plasma and interstitial fluid.There were no gender difference or correlation between COP in interstitial fluid sampled from arm and leg and no significant effect on interstitial COP of gravity.Prolonged implantation time did not affect interstitial COP.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics, Haukeland University Hospital, Bergen, Norway; Department of Clinical Medicine, University of Bergen, Bergen, Norway.

ABSTRACT

Objective: The colloid osmotic pressure (COP) of plasma and interstitial fluid play important roles in transvascular fluid exchange. COP values for monitoring fluid balance in healthy and sick children have not been established. This study set out to determine reference values of COP in healthy children.

Materials and methods: COP in plasma and interstitial fluid harvested from nylon wicks was measured in 99 healthy children from 2 to 10 years of age. Nylon wicks were implanted subcutaneously in arm and leg while patients were sedated and intubated during a minor surgical procedure. COP was analyzed in a colloid osmometer designed for small fluid samples.

Results: The mean plasma COP in all children was 25.6 ± 3.3 mmHg. Arbitrary division of children in four different age groups, showed no significant difference in plasma or interstitial fluid COP values for patients less than 8 years, whereas patients of 8-10 years had significant higher COP both in plasma and interstitial fluid. There were no gender difference or correlation between COP in interstitial fluid sampled from arm and leg and no significant effect on interstitial COP of gravity. Prolonged implantation time did not affect interstitial COP.

Conclusion: Plasma and interstitial COP in healthy children are comparable to adults and COP seems to increase with age in children. Knowledge of the interaction between colloid osmotic forces can be helpful in diseases associated with fluid imbalance and may be crucial in deciding different fluid treatment options.

Trial registration: ClinicalTrials.gov NCT01044641.

No MeSH data available.


Related in: MedlinePlus

Transcapillary gradient in COP.(ΔCOP = COPp—COPi (arm and leg merged)) ΔCOP related to age, with significant difference between 4–5 years and 2–3 years (P = 0.017 *) and between 6–7 years and 2–3 years (P < 0.001 ***).
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pone.0122779.g005: Transcapillary gradient in COP.(ΔCOP = COPp—COPi (arm and leg merged)) ΔCOP related to age, with significant difference between 4–5 years and 2–3 years (P = 0.017 *) and between 6–7 years and 2–3 years (P < 0.001 ***).

Mentions: There was a significantly increasing colloid osmotic pressure gradient between plasma and interstitium (ΔCOP) from 10.1 ± 2.8 mmHg at 2–3 years to 14.5 ± 3.9 mmHg at 6–7 years (Fig 5). The difference tended to be smaller for the 8–10 year old group (12.5 ± 2.6 mmHg), but there were only five observations.


Interstitial fluid colloid osmotic pressure in healthy children.

Guthe HJ, Indrebø M, Nedrebø T, Norgård G, Wiig H, Berg A - PLoS ONE (2015)

Transcapillary gradient in COP.(ΔCOP = COPp—COPi (arm and leg merged)) ΔCOP related to age, with significant difference between 4–5 years and 2–3 years (P = 0.017 *) and between 6–7 years and 2–3 years (P < 0.001 ***).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4390290&req=5

pone.0122779.g005: Transcapillary gradient in COP.(ΔCOP = COPp—COPi (arm and leg merged)) ΔCOP related to age, with significant difference between 4–5 years and 2–3 years (P = 0.017 *) and between 6–7 years and 2–3 years (P < 0.001 ***).
Mentions: There was a significantly increasing colloid osmotic pressure gradient between plasma and interstitium (ΔCOP) from 10.1 ± 2.8 mmHg at 2–3 years to 14.5 ± 3.9 mmHg at 6–7 years (Fig 5). The difference tended to be smaller for the 8–10 year old group (12.5 ± 2.6 mmHg), but there were only five observations.

Bottom Line: Arbitrary division of children in four different age groups, showed no significant difference in plasma or interstitial fluid COP values for patients less than 8 years, whereas patients of 8-10 years had significant higher COP both in plasma and interstitial fluid.There were no gender difference or correlation between COP in interstitial fluid sampled from arm and leg and no significant effect on interstitial COP of gravity.Prolonged implantation time did not affect interstitial COP.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics, Haukeland University Hospital, Bergen, Norway; Department of Clinical Medicine, University of Bergen, Bergen, Norway.

ABSTRACT

Objective: The colloid osmotic pressure (COP) of plasma and interstitial fluid play important roles in transvascular fluid exchange. COP values for monitoring fluid balance in healthy and sick children have not been established. This study set out to determine reference values of COP in healthy children.

Materials and methods: COP in plasma and interstitial fluid harvested from nylon wicks was measured in 99 healthy children from 2 to 10 years of age. Nylon wicks were implanted subcutaneously in arm and leg while patients were sedated and intubated during a minor surgical procedure. COP was analyzed in a colloid osmometer designed for small fluid samples.

Results: The mean plasma COP in all children was 25.6 ± 3.3 mmHg. Arbitrary division of children in four different age groups, showed no significant difference in plasma or interstitial fluid COP values for patients less than 8 years, whereas patients of 8-10 years had significant higher COP both in plasma and interstitial fluid. There were no gender difference or correlation between COP in interstitial fluid sampled from arm and leg and no significant effect on interstitial COP of gravity. Prolonged implantation time did not affect interstitial COP.

Conclusion: Plasma and interstitial COP in healthy children are comparable to adults and COP seems to increase with age in children. Knowledge of the interaction between colloid osmotic forces can be helpful in diseases associated with fluid imbalance and may be crucial in deciding different fluid treatment options.

Trial registration: ClinicalTrials.gov NCT01044641.

No MeSH data available.


Related in: MedlinePlus