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Interstitial fluid colloid osmotic pressure in healthy children.

Guthe HJ, Indrebø M, Nedrebø T, Norgård G, Wiig H, Berg A - PLoS ONE (2015)

Bottom Line: Arbitrary division of children in four different age groups, showed no significant difference in plasma or interstitial fluid COP values for patients less than 8 years, whereas patients of 8-10 years had significant higher COP both in plasma and interstitial fluid.There were no gender difference or correlation between COP in interstitial fluid sampled from arm and leg and no significant effect on interstitial COP of gravity.Prolonged implantation time did not affect interstitial COP.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics, Haukeland University Hospital, Bergen, Norway; Department of Clinical Medicine, University of Bergen, Bergen, Norway.

ABSTRACT

Objective: The colloid osmotic pressure (COP) of plasma and interstitial fluid play important roles in transvascular fluid exchange. COP values for monitoring fluid balance in healthy and sick children have not been established. This study set out to determine reference values of COP in healthy children.

Materials and methods: COP in plasma and interstitial fluid harvested from nylon wicks was measured in 99 healthy children from 2 to 10 years of age. Nylon wicks were implanted subcutaneously in arm and leg while patients were sedated and intubated during a minor surgical procedure. COP was analyzed in a colloid osmometer designed for small fluid samples.

Results: The mean plasma COP in all children was 25.6 ± 3.3 mmHg. Arbitrary division of children in four different age groups, showed no significant difference in plasma or interstitial fluid COP values for patients less than 8 years, whereas patients of 8-10 years had significant higher COP both in plasma and interstitial fluid. There were no gender difference or correlation between COP in interstitial fluid sampled from arm and leg and no significant effect on interstitial COP of gravity. Prolonged implantation time did not affect interstitial COP.

Conclusion: Plasma and interstitial COP in healthy children are comparable to adults and COP seems to increase with age in children. Knowledge of the interaction between colloid osmotic forces can be helpful in diseases associated with fluid imbalance and may be crucial in deciding different fluid treatment options.

Trial registration: ClinicalTrials.gov NCT01044641.

No MeSH data available.


Related in: MedlinePlus

Colloid osmotic pressure in arm and leg.Colloid osmotic pressure from wicks after implantation in arm vs. leg related to age. There was no significant difference in the pressures obtained in arm and leg.
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pone.0122779.g004: Colloid osmotic pressure in arm and leg.Colloid osmotic pressure from wicks after implantation in arm vs. leg related to age. There was no significant difference in the pressures obtained in arm and leg.

Mentions: Interstitial COP: Mean COPi (arm and leg together) for all children was 13.9 ± 3.5 mmHg. There were no significant differences between the 2–3, 4–5 and 6–7 year age groups, (14.2 ± 3.2 mmHg, 13.6 ± 3.4 mmHg and 13.2 ± 4.1 mmHg respectively), but the 8–10 age group had a higher value (17.2 ± 3.2 mmHg) than the younger children, P < 0.05 (Fig 3). There were no significant differences between arm and leg COPi within any of the groups or between groups (Fig 4). In contrast to the other groups, the COPi tended to be lower in the leg than in the arm in the 8–10 year old group, but observations were few. The mean COPi (arm and leg altogether) from patients with blood loss over 10% of CBV was significantly higher than the COPi obtained from the other patients (16.0 ± 4.0 mmHg vs.14.0 ± 3.6 mmHg, P = 0.048).


Interstitial fluid colloid osmotic pressure in healthy children.

Guthe HJ, Indrebø M, Nedrebø T, Norgård G, Wiig H, Berg A - PLoS ONE (2015)

Colloid osmotic pressure in arm and leg.Colloid osmotic pressure from wicks after implantation in arm vs. leg related to age. There was no significant difference in the pressures obtained in arm and leg.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4390290&req=5

pone.0122779.g004: Colloid osmotic pressure in arm and leg.Colloid osmotic pressure from wicks after implantation in arm vs. leg related to age. There was no significant difference in the pressures obtained in arm and leg.
Mentions: Interstitial COP: Mean COPi (arm and leg together) for all children was 13.9 ± 3.5 mmHg. There were no significant differences between the 2–3, 4–5 and 6–7 year age groups, (14.2 ± 3.2 mmHg, 13.6 ± 3.4 mmHg and 13.2 ± 4.1 mmHg respectively), but the 8–10 age group had a higher value (17.2 ± 3.2 mmHg) than the younger children, P < 0.05 (Fig 3). There were no significant differences between arm and leg COPi within any of the groups or between groups (Fig 4). In contrast to the other groups, the COPi tended to be lower in the leg than in the arm in the 8–10 year old group, but observations were few. The mean COPi (arm and leg altogether) from patients with blood loss over 10% of CBV was significantly higher than the COPi obtained from the other patients (16.0 ± 4.0 mmHg vs.14.0 ± 3.6 mmHg, P = 0.048).

Bottom Line: Arbitrary division of children in four different age groups, showed no significant difference in plasma or interstitial fluid COP values for patients less than 8 years, whereas patients of 8-10 years had significant higher COP both in plasma and interstitial fluid.There were no gender difference or correlation between COP in interstitial fluid sampled from arm and leg and no significant effect on interstitial COP of gravity.Prolonged implantation time did not affect interstitial COP.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics, Haukeland University Hospital, Bergen, Norway; Department of Clinical Medicine, University of Bergen, Bergen, Norway.

ABSTRACT

Objective: The colloid osmotic pressure (COP) of plasma and interstitial fluid play important roles in transvascular fluid exchange. COP values for monitoring fluid balance in healthy and sick children have not been established. This study set out to determine reference values of COP in healthy children.

Materials and methods: COP in plasma and interstitial fluid harvested from nylon wicks was measured in 99 healthy children from 2 to 10 years of age. Nylon wicks were implanted subcutaneously in arm and leg while patients were sedated and intubated during a minor surgical procedure. COP was analyzed in a colloid osmometer designed for small fluid samples.

Results: The mean plasma COP in all children was 25.6 ± 3.3 mmHg. Arbitrary division of children in four different age groups, showed no significant difference in plasma or interstitial fluid COP values for patients less than 8 years, whereas patients of 8-10 years had significant higher COP both in plasma and interstitial fluid. There were no gender difference or correlation between COP in interstitial fluid sampled from arm and leg and no significant effect on interstitial COP of gravity. Prolonged implantation time did not affect interstitial COP.

Conclusion: Plasma and interstitial COP in healthy children are comparable to adults and COP seems to increase with age in children. Knowledge of the interaction between colloid osmotic forces can be helpful in diseases associated with fluid imbalance and may be crucial in deciding different fluid treatment options.

Trial registration: ClinicalTrials.gov NCT01044641.

No MeSH data available.


Related in: MedlinePlus