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Effect of genome and environment on metabolic and inflammatory profiles.

Sirota M, Willemsen G, Sundar P, Pitts SJ, Potluri S, Prifti E, Kennedy S, Ehrlich SD, Neuteboom J, Kluft C, Malone KE, Cox DR, de Geus EJ, Boomsma DI - PLoS ONE (2015)

Bottom Line: The average similarity across the full phenotypic profile was higher for MZ twin pairs than for spouse pairs, and lowest for pairs of unrelated individuals.Cohabiting MZ twins were more similar in their phenotypic profile compared to MZ twins who no longer lived together.The correspondence in the phenotypic profile is therefore determined to a large degree by familial, mostly genetic, factors, while household factors contribute to a lesser degree to profile similarity.

View Article: PubMed Central - PubMed

Affiliation: Rinat-Pfizer, South San Francisco, California, United States of America.

ABSTRACT
Twin and family studies have established the contribution of genetic factors to variation in metabolic, hematologic and immunological parameters. The majority of these studies analyzed single or combined traits into pre-defined syndromes. In the present study, we explore an alternative multivariate approach in which a broad range of metabolic, hematologic, and immunological traits are analyzed simultaneously to determine the resemblance of monozygotic (MZ) twin pairs, twin-spouse pairs and unrelated, non-cohabiting individuals. A total of 517 participants from the Netherlands Twin Register, including 210 MZ twin pairs and 64 twin-spouse pairs, took part in the study. Data were collected on body composition, blood pressure, heart rate, and multiple biomarkers assessed in fasting blood samples, including lipid levels, glucose, insulin, liver enzymes, hematological measurements and cytokine levels. For all 51 measured traits, pair-wise Pearson correlations, correcting for family relatedness, were calculated across all the individuals in the cohort. Hierarchical clustering techniques were applied to group the measured traits into sub-clusters based on similarity. Sub-clusters were observed among metabolic traits and among inflammatory markers. We defined a phenotypic profile as the collection of all the traits measured for a given individual. Average within-pair similarity of phenotypic profiles was determined for the groups of MZ twin pairs, spouse pairs and pairs of unrelated individuals. The average similarity across the full phenotypic profile was higher for MZ twin pairs than for spouse pairs, and lowest for pairs of unrelated individuals. Cohabiting MZ twins were more similar in their phenotypic profile compared to MZ twins who no longer lived together. The correspondence in the phenotypic profile is therefore determined to a large degree by familial, mostly genetic, factors, while household factors contribute to a lesser degree to profile similarity.

No MeSH data available.


Examples of traits and their concordance in twins.MZ twin pair concordance for A) height, B) telomere length, C) IL6 receptor, D) IL6. In black the correlations for twins living apart, in red the correlations for twins living together. Values shown are sex and age corrected residuals (see Methods).
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pone.0120898.g004: Examples of traits and their concordance in twins.MZ twin pair concordance for A) height, B) telomere length, C) IL6 receptor, D) IL6. In black the correlations for twins living apart, in red the correlations for twins living together. Values shown are sex and age corrected residuals (see Methods).

Mentions: MZ pair resemblance for certain traits is more striking than for others (Fig. 4A, Table 2). As expected [31], highest resemblance was found for height (correlation coefficient = 0.9, p-value < 2.2e16). In addition, telomere length, which has been previously associated with normal ageing[32,33], was highly correlated (correlation coefficient = 0.875, p-value < 2.2e16) in MZ twins (Fig. 4B). This is in line with a previous study by Broer et al. [34], who also demonstrated high heritability for telomere length. We further observed a high MZ twin correlation for the plasma level of the soluble IL6 receptor (correlation coefficient = 0.8, p-value < 2.2e16), whereas the resemblance for plasma levels of the cytokine itself was very low (correlation coefficient = 0.09, p-value = ns) Fig. 4C and 4D.


Effect of genome and environment on metabolic and inflammatory profiles.

Sirota M, Willemsen G, Sundar P, Pitts SJ, Potluri S, Prifti E, Kennedy S, Ehrlich SD, Neuteboom J, Kluft C, Malone KE, Cox DR, de Geus EJ, Boomsma DI - PLoS ONE (2015)

Examples of traits and their concordance in twins.MZ twin pair concordance for A) height, B) telomere length, C) IL6 receptor, D) IL6. In black the correlations for twins living apart, in red the correlations for twins living together. Values shown are sex and age corrected residuals (see Methods).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4390246&req=5

pone.0120898.g004: Examples of traits and their concordance in twins.MZ twin pair concordance for A) height, B) telomere length, C) IL6 receptor, D) IL6. In black the correlations for twins living apart, in red the correlations for twins living together. Values shown are sex and age corrected residuals (see Methods).
Mentions: MZ pair resemblance for certain traits is more striking than for others (Fig. 4A, Table 2). As expected [31], highest resemblance was found for height (correlation coefficient = 0.9, p-value < 2.2e16). In addition, telomere length, which has been previously associated with normal ageing[32,33], was highly correlated (correlation coefficient = 0.875, p-value < 2.2e16) in MZ twins (Fig. 4B). This is in line with a previous study by Broer et al. [34], who also demonstrated high heritability for telomere length. We further observed a high MZ twin correlation for the plasma level of the soluble IL6 receptor (correlation coefficient = 0.8, p-value < 2.2e16), whereas the resemblance for plasma levels of the cytokine itself was very low (correlation coefficient = 0.09, p-value = ns) Fig. 4C and 4D.

Bottom Line: The average similarity across the full phenotypic profile was higher for MZ twin pairs than for spouse pairs, and lowest for pairs of unrelated individuals.Cohabiting MZ twins were more similar in their phenotypic profile compared to MZ twins who no longer lived together.The correspondence in the phenotypic profile is therefore determined to a large degree by familial, mostly genetic, factors, while household factors contribute to a lesser degree to profile similarity.

View Article: PubMed Central - PubMed

Affiliation: Rinat-Pfizer, South San Francisco, California, United States of America.

ABSTRACT
Twin and family studies have established the contribution of genetic factors to variation in metabolic, hematologic and immunological parameters. The majority of these studies analyzed single or combined traits into pre-defined syndromes. In the present study, we explore an alternative multivariate approach in which a broad range of metabolic, hematologic, and immunological traits are analyzed simultaneously to determine the resemblance of monozygotic (MZ) twin pairs, twin-spouse pairs and unrelated, non-cohabiting individuals. A total of 517 participants from the Netherlands Twin Register, including 210 MZ twin pairs and 64 twin-spouse pairs, took part in the study. Data were collected on body composition, blood pressure, heart rate, and multiple biomarkers assessed in fasting blood samples, including lipid levels, glucose, insulin, liver enzymes, hematological measurements and cytokine levels. For all 51 measured traits, pair-wise Pearson correlations, correcting for family relatedness, were calculated across all the individuals in the cohort. Hierarchical clustering techniques were applied to group the measured traits into sub-clusters based on similarity. Sub-clusters were observed among metabolic traits and among inflammatory markers. We defined a phenotypic profile as the collection of all the traits measured for a given individual. Average within-pair similarity of phenotypic profiles was determined for the groups of MZ twin pairs, spouse pairs and pairs of unrelated individuals. The average similarity across the full phenotypic profile was higher for MZ twin pairs than for spouse pairs, and lowest for pairs of unrelated individuals. Cohabiting MZ twins were more similar in their phenotypic profile compared to MZ twins who no longer lived together. The correspondence in the phenotypic profile is therefore determined to a large degree by familial, mostly genetic, factors, while household factors contribute to a lesser degree to profile similarity.

No MeSH data available.