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Associations between renal hyperfiltration and serum alkaline phosphatase.

Oh SW, Han KH, Han SY - PLoS ONE (2015)

Bottom Line: ALP quartiles were significantly associated with albuminuria in participants with eGFR ≥ 60 ml/min/1.73m2.In addition, hyperfiltration was significantly associated with hemoglobin, triglyceride, white blood cell count, DM, smoking, and alcohol consumption (P<0.05).Higher ALP levels are significantly associated with renal hyperfiltration in Korean general population.

View Article: PubMed Central - PubMed

Affiliation: Division of Nephrology, Department of Internal Medicine, Ilsan-Paik Hospital, Inje University College of Medicine, Goyang, Korea.

ABSTRACT
Renal hyperfiltration, which is associated with renal injury, occurs in diabetic or obese individuals. Serum alkaline phosphatase (ALP) level is also elevated in patients with diabetes (DM) or metabolic syndrome (MS), and increased urinary excretion of ALP has been demonstrated in patients who have hyperfiltration and tubular damage. However, little was investigated about the association between hyperfiltration and serum ALP level. A retrospective observational study of the 21,308 adults in the Korea National Health and Nutrition Examination Survey IV-V databases (2008-2011) was performed. Renal hyperfiltration was defined as exceeding the age- and sex-specific 97.5th percentile. We divided participants into 4 groups according to their estimated glomerular filtration rate (eGFR): >120, 90-119, 60-89, and <60 mL/min/1.73 m2. The participants with eGFR >120 mL/min/1.73 m2 showed the highest risk for MS, in the highest ALP quartiles (3.848, 95% CI, 1.876-7.892), compared to the lowest quartile. Similarly, the highest risk for DM, in the highest ALP quartiles, was observed in participants with eGFR >120 ml/min/1.73 m2 (2.166, 95% CI, 1.084-4.329). ALP quartiles were significantly associated with albuminuria in participants with eGFR ≥ 60 ml/min/1.73m2. The highest ALP quartile had a 1.631-fold risk elevation for albuminuria with adjustment of age and sex. (95% CI, 1.158-2.297, P = 0.005). After adjustment, the highest ALP quartile had a 1.624-fold risk elevation, for renal hyperfiltration (95% CI, 1.204-2.192, P = 0.002). In addition, hyperfiltration was significantly associated with hemoglobin, triglyceride, white blood cell count, DM, smoking, and alcohol consumption (P<0.05). The relationship between serum ALP and metabolic disorders is stronger in participants with an upper-normal range of eGFR. Higher ALP levels are significantly associated with renal hyperfiltration in Korean general population.

No MeSH data available.


Related in: MedlinePlus

Distribution of estimated glomerular filtration rate by sex and age.The 97.5th percentiles are shown in 10-year age groups. Hyperfiltration was defined as an estimated glomerular filtration rate (eGFR) over the age- and sex-specific 97.5th percentile.
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pone.0122921.g002: Distribution of estimated glomerular filtration rate by sex and age.The 97.5th percentiles are shown in 10-year age groups. Hyperfiltration was defined as an estimated glomerular filtration rate (eGFR) over the age- and sex-specific 97.5th percentile.

Mentions: Renal hyperfiltration was defined as eGFR exceeding the age- and sex-specific 97.5th percentile. The reference values for hyperfiltration for each 10-year age group are shown in Fig 2. We evaluate the associations between hyperfiltration and ALP quartiles, in participants with eGFR ≥ 60 ml/min/1.73 m2. After adjustment, the highest ALP quartile had a 1.624-fold risk elevation for hyperfiltration (95% CI, 1.204–2.192, P = 0.002). In addition, hyperfiltration was significantly associated with hemoglobin, triglyceride, WBC, DM, smoking, and alcohol consumption (P<0.05) (Table 4).


Associations between renal hyperfiltration and serum alkaline phosphatase.

Oh SW, Han KH, Han SY - PLoS ONE (2015)

Distribution of estimated glomerular filtration rate by sex and age.The 97.5th percentiles are shown in 10-year age groups. Hyperfiltration was defined as an estimated glomerular filtration rate (eGFR) over the age- and sex-specific 97.5th percentile.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4390244&req=5

pone.0122921.g002: Distribution of estimated glomerular filtration rate by sex and age.The 97.5th percentiles are shown in 10-year age groups. Hyperfiltration was defined as an estimated glomerular filtration rate (eGFR) over the age- and sex-specific 97.5th percentile.
Mentions: Renal hyperfiltration was defined as eGFR exceeding the age- and sex-specific 97.5th percentile. The reference values for hyperfiltration for each 10-year age group are shown in Fig 2. We evaluate the associations between hyperfiltration and ALP quartiles, in participants with eGFR ≥ 60 ml/min/1.73 m2. After adjustment, the highest ALP quartile had a 1.624-fold risk elevation for hyperfiltration (95% CI, 1.204–2.192, P = 0.002). In addition, hyperfiltration was significantly associated with hemoglobin, triglyceride, WBC, DM, smoking, and alcohol consumption (P<0.05) (Table 4).

Bottom Line: ALP quartiles were significantly associated with albuminuria in participants with eGFR ≥ 60 ml/min/1.73m2.In addition, hyperfiltration was significantly associated with hemoglobin, triglyceride, white blood cell count, DM, smoking, and alcohol consumption (P<0.05).Higher ALP levels are significantly associated with renal hyperfiltration in Korean general population.

View Article: PubMed Central - PubMed

Affiliation: Division of Nephrology, Department of Internal Medicine, Ilsan-Paik Hospital, Inje University College of Medicine, Goyang, Korea.

ABSTRACT
Renal hyperfiltration, which is associated with renal injury, occurs in diabetic or obese individuals. Serum alkaline phosphatase (ALP) level is also elevated in patients with diabetes (DM) or metabolic syndrome (MS), and increased urinary excretion of ALP has been demonstrated in patients who have hyperfiltration and tubular damage. However, little was investigated about the association between hyperfiltration and serum ALP level. A retrospective observational study of the 21,308 adults in the Korea National Health and Nutrition Examination Survey IV-V databases (2008-2011) was performed. Renal hyperfiltration was defined as exceeding the age- and sex-specific 97.5th percentile. We divided participants into 4 groups according to their estimated glomerular filtration rate (eGFR): >120, 90-119, 60-89, and <60 mL/min/1.73 m2. The participants with eGFR >120 mL/min/1.73 m2 showed the highest risk for MS, in the highest ALP quartiles (3.848, 95% CI, 1.876-7.892), compared to the lowest quartile. Similarly, the highest risk for DM, in the highest ALP quartiles, was observed in participants with eGFR >120 ml/min/1.73 m2 (2.166, 95% CI, 1.084-4.329). ALP quartiles were significantly associated with albuminuria in participants with eGFR ≥ 60 ml/min/1.73m2. The highest ALP quartile had a 1.631-fold risk elevation for albuminuria with adjustment of age and sex. (95% CI, 1.158-2.297, P = 0.005). After adjustment, the highest ALP quartile had a 1.624-fold risk elevation, for renal hyperfiltration (95% CI, 1.204-2.192, P = 0.002). In addition, hyperfiltration was significantly associated with hemoglobin, triglyceride, white blood cell count, DM, smoking, and alcohol consumption (P<0.05). The relationship between serum ALP and metabolic disorders is stronger in participants with an upper-normal range of eGFR. Higher ALP levels are significantly associated with renal hyperfiltration in Korean general population.

No MeSH data available.


Related in: MedlinePlus