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ALDB: a domestic-animal long noncoding RNA database.

Li A, Zhang J, Zhou Z, Wang L, Liu Y, Liu Y - PLoS ONE (2015)

Bottom Line: Long noncoding RNAs (lncRNAs) have attracted significant attention in recent years due to their important roles in many biological processes.Moreover, a collection of interfaces and applications, such as the Basic Local Alignment Search Tool (BLAST), the Generic Genome Browser (GBrowse) and flexible search functionalities, are available to help users effectively explore, analyze and download data related to domestic-animal lncRNAs.A user-friendly web interface, integrated information and tools make it valuable to researchers in their studies.

View Article: PubMed Central - PubMed

Affiliation: School of Computer Science and Technology, Xidian University, Xi'an, Shaanxi, PR China; School of Computer Science and Engineering, Xi'an University of Technology, Xi'an, Shaanxi, PR China.

ABSTRACT

Background: Long noncoding RNAs (lncRNAs) have attracted significant attention in recent years due to their important roles in many biological processes. Domestic animals constitute a unique resource for understanding the genetic basis of phenotypic variation and are ideal models relevant to diverse areas of biomedical research. With improving sequencing technologies, numerous domestic-animal lncRNAs are now available. Thus, there is an immediate need for a database resource that can assist researchers to store, organize, analyze and visualize domestic-animal lncRNAs.

Results: The domestic-animal lncRNA database, named ALDB, is the first comprehensive database with a focus on the domestic-animal lncRNAs. It currently archives 12,103 pig intergenic lncRNAs (lincRNAs), 8,923 chicken lincRNAs and 8,250 cow lincRNAs. In addition to the annotations of lincRNAs, it offers related data that is not available yet in existing lncRNA databases (lncRNAdb and NONCODE), such as genome-wide expression profiles and animal quantitative trait loci (QTLs) of domestic animals. Moreover, a collection of interfaces and applications, such as the Basic Local Alignment Search Tool (BLAST), the Generic Genome Browser (GBrowse) and flexible search functionalities, are available to help users effectively explore, analyze and download data related to domestic-animal lncRNAs.

Conclusions: ALDB enables the exploration and comparative analysis of lncRNAs in domestic animals. A user-friendly web interface, integrated information and tools make it valuable to researchers in their studies. ALDB is freely available from http://res.xaut.edu.cn/aldb/index.jsp.

No MeSH data available.


Identification of lincRNAs and calculation of expression levels.(A) Computational pipeline to identifying lincRNAs. (B) Pipeline of calculation of expression levels for protein-coding and lncRNA genes. Blue box: input data. Green box: processing. Orange box: outcomes.
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pone.0124003.g001: Identification of lincRNAs and calculation of expression levels.(A) Computational pipeline to identifying lincRNAs. (B) Pipeline of calculation of expression levels for protein-coding and lncRNA genes. Blue box: input data. Green box: processing. Orange box: outcomes.

Mentions: Fig 1A highlights the main steps of the pipeline. The approach to extracting high-confidential and reliable transcripts from RNA-seq data differs from that from UniGene data.


ALDB: a domestic-animal long noncoding RNA database.

Li A, Zhang J, Zhou Z, Wang L, Liu Y, Liu Y - PLoS ONE (2015)

Identification of lincRNAs and calculation of expression levels.(A) Computational pipeline to identifying lincRNAs. (B) Pipeline of calculation of expression levels for protein-coding and lncRNA genes. Blue box: input data. Green box: processing. Orange box: outcomes.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4390226&req=5

pone.0124003.g001: Identification of lincRNAs and calculation of expression levels.(A) Computational pipeline to identifying lincRNAs. (B) Pipeline of calculation of expression levels for protein-coding and lncRNA genes. Blue box: input data. Green box: processing. Orange box: outcomes.
Mentions: Fig 1A highlights the main steps of the pipeline. The approach to extracting high-confidential and reliable transcripts from RNA-seq data differs from that from UniGene data.

Bottom Line: Long noncoding RNAs (lncRNAs) have attracted significant attention in recent years due to their important roles in many biological processes.Moreover, a collection of interfaces and applications, such as the Basic Local Alignment Search Tool (BLAST), the Generic Genome Browser (GBrowse) and flexible search functionalities, are available to help users effectively explore, analyze and download data related to domestic-animal lncRNAs.A user-friendly web interface, integrated information and tools make it valuable to researchers in their studies.

View Article: PubMed Central - PubMed

Affiliation: School of Computer Science and Technology, Xidian University, Xi'an, Shaanxi, PR China; School of Computer Science and Engineering, Xi'an University of Technology, Xi'an, Shaanxi, PR China.

ABSTRACT

Background: Long noncoding RNAs (lncRNAs) have attracted significant attention in recent years due to their important roles in many biological processes. Domestic animals constitute a unique resource for understanding the genetic basis of phenotypic variation and are ideal models relevant to diverse areas of biomedical research. With improving sequencing technologies, numerous domestic-animal lncRNAs are now available. Thus, there is an immediate need for a database resource that can assist researchers to store, organize, analyze and visualize domestic-animal lncRNAs.

Results: The domestic-animal lncRNA database, named ALDB, is the first comprehensive database with a focus on the domestic-animal lncRNAs. It currently archives 12,103 pig intergenic lncRNAs (lincRNAs), 8,923 chicken lincRNAs and 8,250 cow lincRNAs. In addition to the annotations of lincRNAs, it offers related data that is not available yet in existing lncRNA databases (lncRNAdb and NONCODE), such as genome-wide expression profiles and animal quantitative trait loci (QTLs) of domestic animals. Moreover, a collection of interfaces and applications, such as the Basic Local Alignment Search Tool (BLAST), the Generic Genome Browser (GBrowse) and flexible search functionalities, are available to help users effectively explore, analyze and download data related to domestic-animal lncRNAs.

Conclusions: ALDB enables the exploration and comparative analysis of lncRNAs in domestic animals. A user-friendly web interface, integrated information and tools make it valuable to researchers in their studies. ALDB is freely available from http://res.xaut.edu.cn/aldb/index.jsp.

No MeSH data available.