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Metastatic colonic adenocarcinoma in breast: report of two cases and review of the literature.

Kothadia JP, Arju R, Kaminski M, Ankireddypalli A, Duddempudi S, Chow J, Giashuddin S - Case Rep Oncol Med (2015)

Bottom Line: Here we present two rare cases, in which colonic adenocarcinomas were found to metastasize to the breast.By immunohistochemical staining, it was confirmed that the neoplastic components were immunoreactive to colonic markers and nonreactive to breast markers, thus further supporting the morphologic findings.It is extremely important to make this distinction between primary breast cancer and a metastatic process, in order to provide the most effective and appropriate treatment for the patient and to avoid any harmful or unnecessary surgical procedures.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, The Brooklyn Hospital Center, An Academic Affiliate of Icahn School of Medicine at Mount Sinai, 121 DeKalb Avenue, Brooklyn, NY 11201, USA.

ABSTRACT
Metastatic adenocarcinoma to the breast from an extramammary site is extremely rare. In the literature, the most current estimate is that extramammary metastases account for only 0.43% of all breast malignancies and that, of these extramammary sites, colon cancer metastases form a very small subset. Most commonly seen metastasis in breast is from a contralateral breast carcinoma, followed by metastasis from hematopoietic neoplasms, malignant melanoma, sarcoma, lung, prostate, and ovary and gastric neoplasms. Here we present two rare cases, in which colonic adenocarcinomas were found to metastasize to the breast. In both cases, core biopsies were obtained from the suspicious areas identified on mammogram. Histopathology revealed neoplastic proliferation of atypical glandular components within benign breast parenchyma which were morphologically consistent with metastatic adenocarcinoma. By immunohistochemical staining, it was confirmed that the neoplastic components were immunoreactive to colonic markers and nonreactive to breast markers, thus further supporting the morphologic findings. It is extremely important to make this distinction between primary breast cancer and a metastatic process, in order to provide the most effective and appropriate treatment for the patient and to avoid any harmful or unnecessary surgical procedures.

No MeSH data available.


Related in: MedlinePlus

Mammographic image of the breast showing highly vascular spiculated hypoechoic mass measuring 1.35 cm × 1.46 cm × 1.22 cm (arrow).
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fig2: Mammographic image of the breast showing highly vascular spiculated hypoechoic mass measuring 1.35 cm × 1.46 cm × 1.22 cm (arrow).

Mentions: In the emergency room, during the physical examination, the patient stated that she noticed a lump in her right breast. On palpation, a small mass was felt deep in the inferior medial aspect of the right breast at 4 o'clock and 9.7 cm from the nipple. No discharge was noted from the nipple. A bilateral digital diagnostic mammogram study was obtained with views in the craniocaudal and mediolateral oblique positions and with additional spot compression views due to the deep nature of the mass. It was found to be highly vascular, speculated, and hypoechoic mass measuring 1.35 cm × 1.46 cm × 1.22 cm (Figure 2). Some benign appearing microcalcifications were also noted bilaterally, but there were no other masses seen in either breast. Additionally, no axillary lymphadenopathy, skin thickening, or nipple retraction was noted.


Metastatic colonic adenocarcinoma in breast: report of two cases and review of the literature.

Kothadia JP, Arju R, Kaminski M, Ankireddypalli A, Duddempudi S, Chow J, Giashuddin S - Case Rep Oncol Med (2015)

Mammographic image of the breast showing highly vascular spiculated hypoechoic mass measuring 1.35 cm × 1.46 cm × 1.22 cm (arrow).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4390182&req=5

fig2: Mammographic image of the breast showing highly vascular spiculated hypoechoic mass measuring 1.35 cm × 1.46 cm × 1.22 cm (arrow).
Mentions: In the emergency room, during the physical examination, the patient stated that she noticed a lump in her right breast. On palpation, a small mass was felt deep in the inferior medial aspect of the right breast at 4 o'clock and 9.7 cm from the nipple. No discharge was noted from the nipple. A bilateral digital diagnostic mammogram study was obtained with views in the craniocaudal and mediolateral oblique positions and with additional spot compression views due to the deep nature of the mass. It was found to be highly vascular, speculated, and hypoechoic mass measuring 1.35 cm × 1.46 cm × 1.22 cm (Figure 2). Some benign appearing microcalcifications were also noted bilaterally, but there were no other masses seen in either breast. Additionally, no axillary lymphadenopathy, skin thickening, or nipple retraction was noted.

Bottom Line: Here we present two rare cases, in which colonic adenocarcinomas were found to metastasize to the breast.By immunohistochemical staining, it was confirmed that the neoplastic components were immunoreactive to colonic markers and nonreactive to breast markers, thus further supporting the morphologic findings.It is extremely important to make this distinction between primary breast cancer and a metastatic process, in order to provide the most effective and appropriate treatment for the patient and to avoid any harmful or unnecessary surgical procedures.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, The Brooklyn Hospital Center, An Academic Affiliate of Icahn School of Medicine at Mount Sinai, 121 DeKalb Avenue, Brooklyn, NY 11201, USA.

ABSTRACT
Metastatic adenocarcinoma to the breast from an extramammary site is extremely rare. In the literature, the most current estimate is that extramammary metastases account for only 0.43% of all breast malignancies and that, of these extramammary sites, colon cancer metastases form a very small subset. Most commonly seen metastasis in breast is from a contralateral breast carcinoma, followed by metastasis from hematopoietic neoplasms, malignant melanoma, sarcoma, lung, prostate, and ovary and gastric neoplasms. Here we present two rare cases, in which colonic adenocarcinomas were found to metastasize to the breast. In both cases, core biopsies were obtained from the suspicious areas identified on mammogram. Histopathology revealed neoplastic proliferation of atypical glandular components within benign breast parenchyma which were morphologically consistent with metastatic adenocarcinoma. By immunohistochemical staining, it was confirmed that the neoplastic components were immunoreactive to colonic markers and nonreactive to breast markers, thus further supporting the morphologic findings. It is extremely important to make this distinction between primary breast cancer and a metastatic process, in order to provide the most effective and appropriate treatment for the patient and to avoid any harmful or unnecessary surgical procedures.

No MeSH data available.


Related in: MedlinePlus