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Metastatic colonic adenocarcinoma in breast: report of two cases and review of the literature.

Kothadia JP, Arju R, Kaminski M, Ankireddypalli A, Duddempudi S, Chow J, Giashuddin S - Case Rep Oncol Med (2015)

Bottom Line: Here we present two rare cases, in which colonic adenocarcinomas were found to metastasize to the breast.By immunohistochemical staining, it was confirmed that the neoplastic components were immunoreactive to colonic markers and nonreactive to breast markers, thus further supporting the morphologic findings.It is extremely important to make this distinction between primary breast cancer and a metastatic process, in order to provide the most effective and appropriate treatment for the patient and to avoid any harmful or unnecessary surgical procedures.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, The Brooklyn Hospital Center, An Academic Affiliate of Icahn School of Medicine at Mount Sinai, 121 DeKalb Avenue, Brooklyn, NY 11201, USA.

ABSTRACT
Metastatic adenocarcinoma to the breast from an extramammary site is extremely rare. In the literature, the most current estimate is that extramammary metastases account for only 0.43% of all breast malignancies and that, of these extramammary sites, colon cancer metastases form a very small subset. Most commonly seen metastasis in breast is from a contralateral breast carcinoma, followed by metastasis from hematopoietic neoplasms, malignant melanoma, sarcoma, lung, prostate, and ovary and gastric neoplasms. Here we present two rare cases, in which colonic adenocarcinomas were found to metastasize to the breast. In both cases, core biopsies were obtained from the suspicious areas identified on mammogram. Histopathology revealed neoplastic proliferation of atypical glandular components within benign breast parenchyma which were morphologically consistent with metastatic adenocarcinoma. By immunohistochemical staining, it was confirmed that the neoplastic components were immunoreactive to colonic markers and nonreactive to breast markers, thus further supporting the morphologic findings. It is extremely important to make this distinction between primary breast cancer and a metastatic process, in order to provide the most effective and appropriate treatment for the patient and to avoid any harmful or unnecessary surgical procedures.

No MeSH data available.


Related in: MedlinePlus

Mammographic image of the breast showing 2 groupings (A and B) of microcalcifications in the upper medial aspect of the right breast.
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Related In: Results  -  Collection


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fig1: Mammographic image of the breast showing 2 groupings (A and B) of microcalcifications in the upper medial aspect of the right breast.

Mentions: A 45-year-old woman with history of stage 4 colon cancer, status after right hemicolectomy in 2012, presented to the outpatient clinic for a follow-up visit and biannual work-up. The patient had received Oxaliplatin with 5-fluorouracil and folinic acid (FOLFOX) and Avastin (bevacizumab) chemotherapy following surgery. Although the CT scans of her lungs and liver did not show any evidence of metastatic disease, the mammogram showed an abnormal density associated with two clusters of microcalcifications in the upper medial aspect of the right breast. The anterior cluster measured approximately 6.8 mm × 5.3 mm in size and was located 3.64 cm from the nipple (Figure 1). The posterior cluster measured 9.3 mm × 7.4 mm and was located 6-7 cm from the nipple. Both clusters showed pleomorphic appearance with linear distribution which was indeterminate but suspicious for neoplasm (BI-RADS 4).


Metastatic colonic adenocarcinoma in breast: report of two cases and review of the literature.

Kothadia JP, Arju R, Kaminski M, Ankireddypalli A, Duddempudi S, Chow J, Giashuddin S - Case Rep Oncol Med (2015)

Mammographic image of the breast showing 2 groupings (A and B) of microcalcifications in the upper medial aspect of the right breast.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4390182&req=5

fig1: Mammographic image of the breast showing 2 groupings (A and B) of microcalcifications in the upper medial aspect of the right breast.
Mentions: A 45-year-old woman with history of stage 4 colon cancer, status after right hemicolectomy in 2012, presented to the outpatient clinic for a follow-up visit and biannual work-up. The patient had received Oxaliplatin with 5-fluorouracil and folinic acid (FOLFOX) and Avastin (bevacizumab) chemotherapy following surgery. Although the CT scans of her lungs and liver did not show any evidence of metastatic disease, the mammogram showed an abnormal density associated with two clusters of microcalcifications in the upper medial aspect of the right breast. The anterior cluster measured approximately 6.8 mm × 5.3 mm in size and was located 3.64 cm from the nipple (Figure 1). The posterior cluster measured 9.3 mm × 7.4 mm and was located 6-7 cm from the nipple. Both clusters showed pleomorphic appearance with linear distribution which was indeterminate but suspicious for neoplasm (BI-RADS 4).

Bottom Line: Here we present two rare cases, in which colonic adenocarcinomas were found to metastasize to the breast.By immunohistochemical staining, it was confirmed that the neoplastic components were immunoreactive to colonic markers and nonreactive to breast markers, thus further supporting the morphologic findings.It is extremely important to make this distinction between primary breast cancer and a metastatic process, in order to provide the most effective and appropriate treatment for the patient and to avoid any harmful or unnecessary surgical procedures.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, The Brooklyn Hospital Center, An Academic Affiliate of Icahn School of Medicine at Mount Sinai, 121 DeKalb Avenue, Brooklyn, NY 11201, USA.

ABSTRACT
Metastatic adenocarcinoma to the breast from an extramammary site is extremely rare. In the literature, the most current estimate is that extramammary metastases account for only 0.43% of all breast malignancies and that, of these extramammary sites, colon cancer metastases form a very small subset. Most commonly seen metastasis in breast is from a contralateral breast carcinoma, followed by metastasis from hematopoietic neoplasms, malignant melanoma, sarcoma, lung, prostate, and ovary and gastric neoplasms. Here we present two rare cases, in which colonic adenocarcinomas were found to metastasize to the breast. In both cases, core biopsies were obtained from the suspicious areas identified on mammogram. Histopathology revealed neoplastic proliferation of atypical glandular components within benign breast parenchyma which were morphologically consistent with metastatic adenocarcinoma. By immunohistochemical staining, it was confirmed that the neoplastic components were immunoreactive to colonic markers and nonreactive to breast markers, thus further supporting the morphologic findings. It is extremely important to make this distinction between primary breast cancer and a metastatic process, in order to provide the most effective and appropriate treatment for the patient and to avoid any harmful or unnecessary surgical procedures.

No MeSH data available.


Related in: MedlinePlus