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Reproducibility in echocardiographic assessment of diastolic function in a population based study (the STANISLAS Cohort study).

Frikha Z, Girerd N, Huttin O, Courand PY, Bozec E, Olivier A, Lamiral Z, Zannad F, Rossignol P - PLoS ONE (2015)

Bottom Line: Limits of agreement of relative differences were narrow (<15%), except for mitral A wave duration and velocity (both <20%) as well as left ventricular mass and pulmonary A wave duration (both <30%).In this validation study within the STANISLAS cohort, diastolic function echocardiographic parameters were found to be highly reproducible.Diastolic dysfunction consequently appears as a highly effective clinical and research tool.

View Article: PubMed Central - PubMed

Affiliation: INSERM, Centre d'Investigations Cliniques 9501, Université de Lorraine, CHU de Nancy, Institut Lorrain du cœur et des vaisseaux, Nancy, France.

ABSTRACT

Introduction: There is limited evidence regarding intra-observer and inter-observer variations in echocardiographic measurements of diastolic function. This study aimed to assess this reproducibly within a population-based cohort study.

Methods: Sixty subjects in sinus rhythm were randomly selected among 4th visit participants of the STANISLAS Cohort (Lorraine region, France). This 4th examination systematically included M-mode, 2-dimensional, DTI and pulsed-wave Doppler echocardiograms. Reproducibility of variables was studied by intra-class correlation coefficients (ICC) and Bland Altman plots.

Results: Our population was on average middle-aged (50 ± 14 y), overweight (BMI = 26 ± 6 kg/m2) and non-smoking (87%) with a quarter of the participants having self-declared hypertension or treated with anti-hypertensive medication(s). Intra-observer ICC were > 0.90 for all analyzed parameters except for left ventricular ejection fraction (LVEF) which was 0.89 (0.81-0.93). The mean relative intra-observer differences were small and limits of agreement of relative differences were narrow for all considered parameters (<5% and <15% respectively). Inter-observer ICC were > 0.90 for all analyzed parameters except for LVEF (ICC = 0.87) and both mitral and pulmonary A wave duration (0.83 and 0.73 respectively). The mean relative inter-observer differences were <5% for all parameters except for pulmonary A wave duration (mean difference = 6.5%). Limits of agreement of relative differences were narrow (<15%), except for mitral A wave duration and velocity (both <20%) as well as left ventricular mass and pulmonary A wave duration (both <30%). Intra-observer agreements with regard to the presence and severity of diastolic dysfunction were excellent (Kappa = 0.93 (0.83-1.00) and 0.88 (0.75-0.99), respectively).

Conclusion: In this validation study within the STANISLAS cohort, diastolic function echocardiographic parameters were found to be highly reproducible. Diastolic dysfunction consequently appears as a highly effective clinical and research tool.

No MeSH data available.


Related in: MedlinePlus

Bland-Altman plots of intra-observer agreement for left ventricular ejection fraction, LV mass, LA Volume, E-wave, E-wave deceleration time, A-wave velocities, A-wave and pulmonary vein reversal A duration, as well as septal and lateral Ep Velocity.
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pone.0122336.g001: Bland-Altman plots of intra-observer agreement for left ventricular ejection fraction, LV mass, LA Volume, E-wave, E-wave deceleration time, A-wave velocities, A-wave and pulmonary vein reversal A duration, as well as septal and lateral Ep Velocity.

Mentions: The mean relative intra-observer differences were <5% for all parameters (Fig 1).The limits of agreement of relative differences for all analyzed parameters were small (2 SDs <15%), indicating a high reproducibility of within-observer measurements. Importantly, the reproducibility of both mitral and Pulmonary A wave duration was excellent (ICC = 0.94 and 0.96 respectively).


Reproducibility in echocardiographic assessment of diastolic function in a population based study (the STANISLAS Cohort study).

Frikha Z, Girerd N, Huttin O, Courand PY, Bozec E, Olivier A, Lamiral Z, Zannad F, Rossignol P - PLoS ONE (2015)

Bland-Altman plots of intra-observer agreement for left ventricular ejection fraction, LV mass, LA Volume, E-wave, E-wave deceleration time, A-wave velocities, A-wave and pulmonary vein reversal A duration, as well as septal and lateral Ep Velocity.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4390157&req=5

pone.0122336.g001: Bland-Altman plots of intra-observer agreement for left ventricular ejection fraction, LV mass, LA Volume, E-wave, E-wave deceleration time, A-wave velocities, A-wave and pulmonary vein reversal A duration, as well as septal and lateral Ep Velocity.
Mentions: The mean relative intra-observer differences were <5% for all parameters (Fig 1).The limits of agreement of relative differences for all analyzed parameters were small (2 SDs <15%), indicating a high reproducibility of within-observer measurements. Importantly, the reproducibility of both mitral and Pulmonary A wave duration was excellent (ICC = 0.94 and 0.96 respectively).

Bottom Line: Limits of agreement of relative differences were narrow (<15%), except for mitral A wave duration and velocity (both <20%) as well as left ventricular mass and pulmonary A wave duration (both <30%).In this validation study within the STANISLAS cohort, diastolic function echocardiographic parameters were found to be highly reproducible.Diastolic dysfunction consequently appears as a highly effective clinical and research tool.

View Article: PubMed Central - PubMed

Affiliation: INSERM, Centre d'Investigations Cliniques 9501, Université de Lorraine, CHU de Nancy, Institut Lorrain du cœur et des vaisseaux, Nancy, France.

ABSTRACT

Introduction: There is limited evidence regarding intra-observer and inter-observer variations in echocardiographic measurements of diastolic function. This study aimed to assess this reproducibly within a population-based cohort study.

Methods: Sixty subjects in sinus rhythm were randomly selected among 4th visit participants of the STANISLAS Cohort (Lorraine region, France). This 4th examination systematically included M-mode, 2-dimensional, DTI and pulsed-wave Doppler echocardiograms. Reproducibility of variables was studied by intra-class correlation coefficients (ICC) and Bland Altman plots.

Results: Our population was on average middle-aged (50 ± 14 y), overweight (BMI = 26 ± 6 kg/m2) and non-smoking (87%) with a quarter of the participants having self-declared hypertension or treated with anti-hypertensive medication(s). Intra-observer ICC were > 0.90 for all analyzed parameters except for left ventricular ejection fraction (LVEF) which was 0.89 (0.81-0.93). The mean relative intra-observer differences were small and limits of agreement of relative differences were narrow for all considered parameters (<5% and <15% respectively). Inter-observer ICC were > 0.90 for all analyzed parameters except for LVEF (ICC = 0.87) and both mitral and pulmonary A wave duration (0.83 and 0.73 respectively). The mean relative inter-observer differences were <5% for all parameters except for pulmonary A wave duration (mean difference = 6.5%). Limits of agreement of relative differences were narrow (<15%), except for mitral A wave duration and velocity (both <20%) as well as left ventricular mass and pulmonary A wave duration (both <30%). Intra-observer agreements with regard to the presence and severity of diastolic dysfunction were excellent (Kappa = 0.93 (0.83-1.00) and 0.88 (0.75-0.99), respectively).

Conclusion: In this validation study within the STANISLAS cohort, diastolic function echocardiographic parameters were found to be highly reproducible. Diastolic dysfunction consequently appears as a highly effective clinical and research tool.

No MeSH data available.


Related in: MedlinePlus