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Expression of polarity genes in human cancer.

Lin WH, Asmann YW, Anastasiadis PZ - Cancer Inform (2015)

Bottom Line: Polarity protein complexes are crucial for epithelial apical-basal polarity and directed cell migration.Since alterations of these processes are common in cancer, polarity proteins have been proposed to function as tumor suppressors or oncogenic promoters.Additionally, polarity expression profiles correlated with disease progression and aggressiveness, as well as with identified cancer types, where specific polarity genes were commonly altered.

View Article: PubMed Central - PubMed

Affiliation: Department of Cancer Biology, Mayo Clinic, Jacksonville, FL, USA.

ABSTRACT
Polarity protein complexes are crucial for epithelial apical-basal polarity and directed cell migration. Since alterations of these processes are common in cancer, polarity proteins have been proposed to function as tumor suppressors or oncogenic promoters. Here, we review the current understanding of polarity protein functions in epithelial homeostasis, as well as tumor formation and progression. As most previous studies focused on the function of single polarity proteins in simplified model systems, we used a genomics approach to systematically examine and identify the expression profiles of polarity genes in human cancer. The expression profiles of polarity genes were distinct in different human tissues and classified cancer types. Additionally, polarity expression profiles correlated with disease progression and aggressiveness, as well as with identified cancer types, where specific polarity genes were commonly altered. In the case of Scribble, gene expression analysis indicated its common amplification and upregulation in human cancer, suggesting a tumor promoting function.

No MeSH data available.


Related in: MedlinePlus

Expression profiles of polarity complex genes in human cancer. The heat map shows differential expression of polarity genes in 15 different cancers. mRNA level relative to the mean of zero is depicted by the blue-red intensities (red = 3.0 high; white = 0.0, mean; blue = −3.0, low). Integrative and hierarchical clusterings were detected using the Patrek genomic suite. Individual polarity genes and cancer types are listed on the x-, and y-axis, respectively.
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f3-cin-suppl.3-2015-015: Expression profiles of polarity complex genes in human cancer. The heat map shows differential expression of polarity genes in 15 different cancers. mRNA level relative to the mean of zero is depicted by the blue-red intensities (red = 3.0 high; white = 0.0, mean; blue = −3.0, low). Integrative and hierarchical clusterings were detected using the Patrek genomic suite. Individual polarity genes and cancer types are listed on the x-, and y-axis, respectively.

Mentions: The expression levels of individual polarity genes from the TCGA tumor RNA sequencing data were compared among 5416 patient samples representing 15 human cancer types (Fig. 2). The polarity genes were analyzed using unsupervised hierarchical clustering analyses. Analysis was restricted to genes related to the three main polarity complexes described earlier, including their known paralogs and functional isoforms. Unexpectedly, clustering resulted in the separation of different cancer types (Fig. 3, Supplementary Table 1). In other words, the expression profiles of the polarity genes classified cancer types, which may be beneficial for distinguishing metastatic cancer versus a new primary cancer of different tissue origin. The data support the hypothesis that different polarity proteins are involved in the progression of different cancer types, and provide a first glimpse into the subset of polarity proteins that may be deregulated in each cancer type.


Expression of polarity genes in human cancer.

Lin WH, Asmann YW, Anastasiadis PZ - Cancer Inform (2015)

Expression profiles of polarity complex genes in human cancer. The heat map shows differential expression of polarity genes in 15 different cancers. mRNA level relative to the mean of zero is depicted by the blue-red intensities (red = 3.0 high; white = 0.0, mean; blue = −3.0, low). Integrative and hierarchical clusterings were detected using the Patrek genomic suite. Individual polarity genes and cancer types are listed on the x-, and y-axis, respectively.
© Copyright Policy - open-access
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC4390136&req=5

f3-cin-suppl.3-2015-015: Expression profiles of polarity complex genes in human cancer. The heat map shows differential expression of polarity genes in 15 different cancers. mRNA level relative to the mean of zero is depicted by the blue-red intensities (red = 3.0 high; white = 0.0, mean; blue = −3.0, low). Integrative and hierarchical clusterings were detected using the Patrek genomic suite. Individual polarity genes and cancer types are listed on the x-, and y-axis, respectively.
Mentions: The expression levels of individual polarity genes from the TCGA tumor RNA sequencing data were compared among 5416 patient samples representing 15 human cancer types (Fig. 2). The polarity genes were analyzed using unsupervised hierarchical clustering analyses. Analysis was restricted to genes related to the three main polarity complexes described earlier, including their known paralogs and functional isoforms. Unexpectedly, clustering resulted in the separation of different cancer types (Fig. 3, Supplementary Table 1). In other words, the expression profiles of the polarity genes classified cancer types, which may be beneficial for distinguishing metastatic cancer versus a new primary cancer of different tissue origin. The data support the hypothesis that different polarity proteins are involved in the progression of different cancer types, and provide a first glimpse into the subset of polarity proteins that may be deregulated in each cancer type.

Bottom Line: Polarity protein complexes are crucial for epithelial apical-basal polarity and directed cell migration.Since alterations of these processes are common in cancer, polarity proteins have been proposed to function as tumor suppressors or oncogenic promoters.Additionally, polarity expression profiles correlated with disease progression and aggressiveness, as well as with identified cancer types, where specific polarity genes were commonly altered.

View Article: PubMed Central - PubMed

Affiliation: Department of Cancer Biology, Mayo Clinic, Jacksonville, FL, USA.

ABSTRACT
Polarity protein complexes are crucial for epithelial apical-basal polarity and directed cell migration. Since alterations of these processes are common in cancer, polarity proteins have been proposed to function as tumor suppressors or oncogenic promoters. Here, we review the current understanding of polarity protein functions in epithelial homeostasis, as well as tumor formation and progression. As most previous studies focused on the function of single polarity proteins in simplified model systems, we used a genomics approach to systematically examine and identify the expression profiles of polarity genes in human cancer. The expression profiles of polarity genes were distinct in different human tissues and classified cancer types. Additionally, polarity expression profiles correlated with disease progression and aggressiveness, as well as with identified cancer types, where specific polarity genes were commonly altered. In the case of Scribble, gene expression analysis indicated its common amplification and upregulation in human cancer, suggesting a tumor promoting function.

No MeSH data available.


Related in: MedlinePlus