Limits...
Expression of polarity genes in human cancer.

Lin WH, Asmann YW, Anastasiadis PZ - Cancer Inform (2015)

Bottom Line: Polarity protein complexes are crucial for epithelial apical-basal polarity and directed cell migration.Since alterations of these processes are common in cancer, polarity proteins have been proposed to function as tumor suppressors or oncogenic promoters.Additionally, polarity expression profiles correlated with disease progression and aggressiveness, as well as with identified cancer types, where specific polarity genes were commonly altered.

View Article: PubMed Central - PubMed

Affiliation: Department of Cancer Biology, Mayo Clinic, Jacksonville, FL, USA.

ABSTRACT
Polarity protein complexes are crucial for epithelial apical-basal polarity and directed cell migration. Since alterations of these processes are common in cancer, polarity proteins have been proposed to function as tumor suppressors or oncogenic promoters. Here, we review the current understanding of polarity protein functions in epithelial homeostasis, as well as tumor formation and progression. As most previous studies focused on the function of single polarity proteins in simplified model systems, we used a genomics approach to systematically examine and identify the expression profiles of polarity genes in human cancer. The expression profiles of polarity genes were distinct in different human tissues and classified cancer types. Additionally, polarity expression profiles correlated with disease progression and aggressiveness, as well as with identified cancer types, where specific polarity genes were commonly altered. In the case of Scribble, gene expression analysis indicated its common amplification and upregulation in human cancer, suggesting a tumor promoting function.

No MeSH data available.


Related in: MedlinePlus

Core members and crosstalk between cell polarity complexes. Epithelial polarity is initiated and maintained mainly by three cell polarity complexes, namely the Crumbs, Par, and Scribble complexes. The Crumbs complex consists of Crb, Pals1, and Patj or its paralog Mupp1; the Par complex consists of Par3, Par6, and aPKC; and the Scribble complex is composed of Scrib, Dlg, and Lgl. A simplified view of the crosstalk between these complexes is shown. The Crumbs and Par complexes localize to the apical region of the cell and work together (arrow) to antagonize the function of the Scribble complex at the basolateral region of the cell.
© Copyright Policy - open-access
Related In: Results  -  Collection


getmorefigures.php?uid=PMC4390136&req=5

f1-cin-suppl.3-2015-015: Core members and crosstalk between cell polarity complexes. Epithelial polarity is initiated and maintained mainly by three cell polarity complexes, namely the Crumbs, Par, and Scribble complexes. The Crumbs complex consists of Crb, Pals1, and Patj or its paralog Mupp1; the Par complex consists of Par3, Par6, and aPKC; and the Scribble complex is composed of Scrib, Dlg, and Lgl. A simplified view of the crosstalk between these complexes is shown. The Crumbs and Par complexes localize to the apical region of the cell and work together (arrow) to antagonize the function of the Scribble complex at the basolateral region of the cell.

Mentions: Establishment and maintenance of epithelial cell polarization is mainly controlled by three polarity complexes, called Crumbs, Partitioning defective (Par), and Scribble (Fig. 1). These complexes, which were originally identified in Drosophila and Caenorhabditis elegans model systems, localize at distinct epithelial membrane domains and function either in a cooperative or antagonistic manner to induce cellular asymmetry and to establish apical–basal polarity.1,21–31 Specifically, the Crumbs and Par complexes localize at the apical regions to specify the apical membrane and determine cell polarity.24–26,32–34 On the other hand, the Scribble complex localizes at the basolateral membrane domain where it excludes apical proteins.1 The function of polarity proteins in epithelial polarity and homeostasis has been reviewed in detail recently,2–4 and is beyond the scope of this paper.


Expression of polarity genes in human cancer.

Lin WH, Asmann YW, Anastasiadis PZ - Cancer Inform (2015)

Core members and crosstalk between cell polarity complexes. Epithelial polarity is initiated and maintained mainly by three cell polarity complexes, namely the Crumbs, Par, and Scribble complexes. The Crumbs complex consists of Crb, Pals1, and Patj or its paralog Mupp1; the Par complex consists of Par3, Par6, and aPKC; and the Scribble complex is composed of Scrib, Dlg, and Lgl. A simplified view of the crosstalk between these complexes is shown. The Crumbs and Par complexes localize to the apical region of the cell and work together (arrow) to antagonize the function of the Scribble complex at the basolateral region of the cell.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4390136&req=5

f1-cin-suppl.3-2015-015: Core members and crosstalk between cell polarity complexes. Epithelial polarity is initiated and maintained mainly by three cell polarity complexes, namely the Crumbs, Par, and Scribble complexes. The Crumbs complex consists of Crb, Pals1, and Patj or its paralog Mupp1; the Par complex consists of Par3, Par6, and aPKC; and the Scribble complex is composed of Scrib, Dlg, and Lgl. A simplified view of the crosstalk between these complexes is shown. The Crumbs and Par complexes localize to the apical region of the cell and work together (arrow) to antagonize the function of the Scribble complex at the basolateral region of the cell.
Mentions: Establishment and maintenance of epithelial cell polarization is mainly controlled by three polarity complexes, called Crumbs, Partitioning defective (Par), and Scribble (Fig. 1). These complexes, which were originally identified in Drosophila and Caenorhabditis elegans model systems, localize at distinct epithelial membrane domains and function either in a cooperative or antagonistic manner to induce cellular asymmetry and to establish apical–basal polarity.1,21–31 Specifically, the Crumbs and Par complexes localize at the apical regions to specify the apical membrane and determine cell polarity.24–26,32–34 On the other hand, the Scribble complex localizes at the basolateral membrane domain where it excludes apical proteins.1 The function of polarity proteins in epithelial polarity and homeostasis has been reviewed in detail recently,2–4 and is beyond the scope of this paper.

Bottom Line: Polarity protein complexes are crucial for epithelial apical-basal polarity and directed cell migration.Since alterations of these processes are common in cancer, polarity proteins have been proposed to function as tumor suppressors or oncogenic promoters.Additionally, polarity expression profiles correlated with disease progression and aggressiveness, as well as with identified cancer types, where specific polarity genes were commonly altered.

View Article: PubMed Central - PubMed

Affiliation: Department of Cancer Biology, Mayo Clinic, Jacksonville, FL, USA.

ABSTRACT
Polarity protein complexes are crucial for epithelial apical-basal polarity and directed cell migration. Since alterations of these processes are common in cancer, polarity proteins have been proposed to function as tumor suppressors or oncogenic promoters. Here, we review the current understanding of polarity protein functions in epithelial homeostasis, as well as tumor formation and progression. As most previous studies focused on the function of single polarity proteins in simplified model systems, we used a genomics approach to systematically examine and identify the expression profiles of polarity genes in human cancer. The expression profiles of polarity genes were distinct in different human tissues and classified cancer types. Additionally, polarity expression profiles correlated with disease progression and aggressiveness, as well as with identified cancer types, where specific polarity genes were commonly altered. In the case of Scribble, gene expression analysis indicated its common amplification and upregulation in human cancer, suggesting a tumor promoting function.

No MeSH data available.


Related in: MedlinePlus