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Change of scaling-induced proinflammatory cytokine on the clinical efficacy of periodontitis treatment.

Shyu KG, Choy CS, Wang DC, Huang WC, Chen SY, Chen CH, Lin CT, Chang CC, Huang YK - ScientificWorldJournal (2015)

Bottom Line: Saliva was obtained from 22 patients diagnosed by dentists as having chronic periodontitis.The proinflammatory cytokine (interleukin-1α (IL-1α), interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor α (TNF-α), and tumor necrosis factor β (TNF-β)) levels were determined using a commercially available kit.Poststimulation IL-1α, IL-6, and IL-8 levels were higher in patients who had an improved treatment outcome.

View Article: PubMed Central - PubMed

Affiliation: Division of Cardiology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei 111, Taiwan ; Graduate Institute of Clinical Medicine, Taipei Medical University, Taipei 110, Taiwan.

ABSTRACT
Proinflammatory cytokines are key inflammatory mediators in periodontitis. This study aimed to investigate the relationship between proinflammatory cytokines in saliva and periodontal status. To investigate the usefulness of cytokines in the therapeutic approach for periodontal disease, the relationship between stimulated cytokine changes and the periodontitis treatment outcome was investigated in this study. Saliva was obtained from 22 patients diagnosed by dentists as having chronic periodontitis. The proinflammatory cytokine (interleukin-1α (IL-1α), interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor α (TNF-α), and tumor necrosis factor β (TNF-β)) levels were determined using a commercially available kit. The IL-1β and IL-6 levels increased, whereas the TNF-β levels decreased with the severity of periodontitis (4 mm pocket percentage). Poststimulation IL-1α, IL-6, and IL-8 levels were higher in patients who had an improved treatment outcome. The differences of IL-6 levels (cut point: 0.05 μg/g) yielded a sensitivity and specificity of 90.0% and 81.82%, respectively, for predicting the periodontitis treatment outcome. Among the proinflammatory cytokines, stimulated IL-6 was an excellent marker for predicting the periodontitis treatment outcome.

No MeSH data available.


Related in: MedlinePlus

Scatter plots of baseline proinflammatory cytokines and 4–6 mm pocket percentages (before treatment) in patients with chronic periodontitis. (a) Interleukin-1α (IL-1α). (b) Interleukin-1β (IL-1β). (c) Interleukin-6 (IL-6). (d) Interleukin-8 (IL-8). (e) Tumor necrosis factor α (TNF-α). (f) Tumor necrosis factor β (TNF-β).
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fig1: Scatter plots of baseline proinflammatory cytokines and 4–6 mm pocket percentages (before treatment) in patients with chronic periodontitis. (a) Interleukin-1α (IL-1α). (b) Interleukin-1β (IL-1β). (c) Interleukin-6 (IL-6). (d) Interleukin-8 (IL-8). (e) Tumor necrosis factor α (TNF-α). (f) Tumor necrosis factor β (TNF-β).

Mentions: The scatter plots in Figure 1 show that proinflammatory cytokines and 4–6 mm pocket percentages are representative of the severity of periodontitis. The β values of IL-1β and IL-6 were 2.04 and 0.34, respectively, indicating that these 2 proinflammatory cytokines significantly increased with the severity of periodontitis. TNF-β significantly decreased with the baseline percentages of 4–6 mm pockets (β value = −0.0057 and P = 0.02).


Change of scaling-induced proinflammatory cytokine on the clinical efficacy of periodontitis treatment.

Shyu KG, Choy CS, Wang DC, Huang WC, Chen SY, Chen CH, Lin CT, Chang CC, Huang YK - ScientificWorldJournal (2015)

Scatter plots of baseline proinflammatory cytokines and 4–6 mm pocket percentages (before treatment) in patients with chronic periodontitis. (a) Interleukin-1α (IL-1α). (b) Interleukin-1β (IL-1β). (c) Interleukin-6 (IL-6). (d) Interleukin-8 (IL-8). (e) Tumor necrosis factor α (TNF-α). (f) Tumor necrosis factor β (TNF-β).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4390110&req=5

fig1: Scatter plots of baseline proinflammatory cytokines and 4–6 mm pocket percentages (before treatment) in patients with chronic periodontitis. (a) Interleukin-1α (IL-1α). (b) Interleukin-1β (IL-1β). (c) Interleukin-6 (IL-6). (d) Interleukin-8 (IL-8). (e) Tumor necrosis factor α (TNF-α). (f) Tumor necrosis factor β (TNF-β).
Mentions: The scatter plots in Figure 1 show that proinflammatory cytokines and 4–6 mm pocket percentages are representative of the severity of periodontitis. The β values of IL-1β and IL-6 were 2.04 and 0.34, respectively, indicating that these 2 proinflammatory cytokines significantly increased with the severity of periodontitis. TNF-β significantly decreased with the baseline percentages of 4–6 mm pockets (β value = −0.0057 and P = 0.02).

Bottom Line: Saliva was obtained from 22 patients diagnosed by dentists as having chronic periodontitis.The proinflammatory cytokine (interleukin-1α (IL-1α), interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor α (TNF-α), and tumor necrosis factor β (TNF-β)) levels were determined using a commercially available kit.Poststimulation IL-1α, IL-6, and IL-8 levels were higher in patients who had an improved treatment outcome.

View Article: PubMed Central - PubMed

Affiliation: Division of Cardiology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei 111, Taiwan ; Graduate Institute of Clinical Medicine, Taipei Medical University, Taipei 110, Taiwan.

ABSTRACT
Proinflammatory cytokines are key inflammatory mediators in periodontitis. This study aimed to investigate the relationship between proinflammatory cytokines in saliva and periodontal status. To investigate the usefulness of cytokines in the therapeutic approach for periodontal disease, the relationship between stimulated cytokine changes and the periodontitis treatment outcome was investigated in this study. Saliva was obtained from 22 patients diagnosed by dentists as having chronic periodontitis. The proinflammatory cytokine (interleukin-1α (IL-1α), interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor α (TNF-α), and tumor necrosis factor β (TNF-β)) levels were determined using a commercially available kit. The IL-1β and IL-6 levels increased, whereas the TNF-β levels decreased with the severity of periodontitis (4 mm pocket percentage). Poststimulation IL-1α, IL-6, and IL-8 levels were higher in patients who had an improved treatment outcome. The differences of IL-6 levels (cut point: 0.05 μg/g) yielded a sensitivity and specificity of 90.0% and 81.82%, respectively, for predicting the periodontitis treatment outcome. Among the proinflammatory cytokines, stimulated IL-6 was an excellent marker for predicting the periodontitis treatment outcome.

No MeSH data available.


Related in: MedlinePlus