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The Neuroprotective Mechanism of Low-Frequency rTMS on Nigral Dopaminergic Neurons of Parkinson's Disease Model Mice.

Dong Q, Wang Y, Gu P, Shao R, Zhao L, Liu X, Wang Z, Wang M - Parkinsons Dis (2015)

Bottom Line: Results.Conclusions.Low-frequency rTMS had a neuroprotective effect on the nigral dopaminergic neuron which might be due to the improved expressions of brain derived neurotrophic factor and glial cell line-derived neurotrophic factor.

View Article: PubMed Central - PubMed

Affiliation: Fifth Department of Neurology, Cangzhou Central Hospital, No. 16 Xinhua Western Road, Cangzhou, Hebei 061000, China.

ABSTRACT
Background. Parkinson's disease is a neurodegenerative disease in elder people, pathophysiologic basis of which is the severe deficiency of dopamine in the striatum. The purpose of the present study was to evaluate the neuroprotective effect of low-frequency rTMS on Parkinson's disease in model mice. Methods. The effects of low-frequency rTMS on the motor function, cortex excitability, neurochemistry, and neurohistopathology of MPTP-induced Parkinson's disease mice were investigated through behavioral detection, electrophysiologic technique, high performance liquid chromatography-electrochemical detection, immunohistochemical staining, and western blot. Results. Low-frequency rTMS could improve the motor coordination impairment of Parkinson's disease mice: the resting motor threshold significantly decreased in the Parkinson's disease mice; the degeneration of nigral dopaminergic neuron and the expression of tyrosine hydroxylase were significantly improved by low-frequency rTMS; moreover, the expressions of brain derived neurotrophic factor and glial cell line derived neurotrophic factor were also improved by low-frequency rTMS. Conclusions. Low-frequency rTMS had a neuroprotective effect on the nigral dopaminergic neuron which might be due to the improved expressions of brain derived neurotrophic factor and glial cell line-derived neurotrophic factor. The present study provided a theoretical basis for the application of low-frequency rTMS in the clinical treatment and recovery of Parkinson's disease.

No MeSH data available.


Related in: MedlinePlus

The comparison of RMT of mice in different groups at different time points.
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fig3: The comparison of RMT of mice in different groups at different time points.

Mentions: Significant decreases of the RMT of mice were observed in MPTP-treated groups compared to that of the NS group after the first injection of MPTP (Figure 3; Table S3) (P < 0.05). The decrease persisted for PD and s-rTMS groups for the left injections but with a mild pattern. For rTMS group, increase of the RMT of mice was observed since the 3rd day after the last injection. The difference of RMT between rTMS group and PD/s-rTMS groups was significant at the 7th day and 14th day (Figure 3; Table S3) (P < 0.05).


The Neuroprotective Mechanism of Low-Frequency rTMS on Nigral Dopaminergic Neurons of Parkinson's Disease Model Mice.

Dong Q, Wang Y, Gu P, Shao R, Zhao L, Liu X, Wang Z, Wang M - Parkinsons Dis (2015)

The comparison of RMT of mice in different groups at different time points.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4390107&req=5

fig3: The comparison of RMT of mice in different groups at different time points.
Mentions: Significant decreases of the RMT of mice were observed in MPTP-treated groups compared to that of the NS group after the first injection of MPTP (Figure 3; Table S3) (P < 0.05). The decrease persisted for PD and s-rTMS groups for the left injections but with a mild pattern. For rTMS group, increase of the RMT of mice was observed since the 3rd day after the last injection. The difference of RMT between rTMS group and PD/s-rTMS groups was significant at the 7th day and 14th day (Figure 3; Table S3) (P < 0.05).

Bottom Line: Results.Conclusions.Low-frequency rTMS had a neuroprotective effect on the nigral dopaminergic neuron which might be due to the improved expressions of brain derived neurotrophic factor and glial cell line-derived neurotrophic factor.

View Article: PubMed Central - PubMed

Affiliation: Fifth Department of Neurology, Cangzhou Central Hospital, No. 16 Xinhua Western Road, Cangzhou, Hebei 061000, China.

ABSTRACT
Background. Parkinson's disease is a neurodegenerative disease in elder people, pathophysiologic basis of which is the severe deficiency of dopamine in the striatum. The purpose of the present study was to evaluate the neuroprotective effect of low-frequency rTMS on Parkinson's disease in model mice. Methods. The effects of low-frequency rTMS on the motor function, cortex excitability, neurochemistry, and neurohistopathology of MPTP-induced Parkinson's disease mice were investigated through behavioral detection, electrophysiologic technique, high performance liquid chromatography-electrochemical detection, immunohistochemical staining, and western blot. Results. Low-frequency rTMS could improve the motor coordination impairment of Parkinson's disease mice: the resting motor threshold significantly decreased in the Parkinson's disease mice; the degeneration of nigral dopaminergic neuron and the expression of tyrosine hydroxylase were significantly improved by low-frequency rTMS; moreover, the expressions of brain derived neurotrophic factor and glial cell line derived neurotrophic factor were also improved by low-frequency rTMS. Conclusions. Low-frequency rTMS had a neuroprotective effect on the nigral dopaminergic neuron which might be due to the improved expressions of brain derived neurotrophic factor and glial cell line-derived neurotrophic factor. The present study provided a theoretical basis for the application of low-frequency rTMS in the clinical treatment and recovery of Parkinson's disease.

No MeSH data available.


Related in: MedlinePlus