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Therapeutic effect of Agaricus brasiliensis on phenylhydrazine-induced neonatal jaundice in rats.

Zhang L, Yuan B, Wang H, Gao Y - Biomed Res Int (2015)

Bottom Line: Administration of ABE dose-dependently reduced the elevated bilirubin level induced by phenylhydrazine.It can be somewhat supported from the results of in vitro bilirubin degradation experiment.ABE treatment also reduced the total antioxidant status (TAOS), cascade O2(-)/SOD, level of NF-κB protein, and adrenomedullin (AM).

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics, Second Hospital of Xi'an Jiaotong University, Xi'an 710004, China.

ABSTRACT
The present study was designed to investigate the effect of Agaricus brasiliensis extract (ABE) on phenylhydrazine-induced neonatal jaundice in rats. Administration of ABE dose-dependently reduced the elevated bilirubin level induced by phenylhydrazine. It can be somewhat supported from the results of in vitro bilirubin degradation experiment. ABE treatment also reduced the total antioxidant status (TAOS), cascade O2(-)/SOD, level of NF-κB protein, and adrenomedullin (AM). Overall, the results of this study demonstrated that Agaricus brasiliensis extract may be beneficial to reducing bilirubin level without causing hepatotoxicity in neonatal jaundice.

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Related in: MedlinePlus

Correlation between serum AM levels and serum bilirubin levels.
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Related In: Results  -  Collection


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fig5: Correlation between serum AM levels and serum bilirubin levels.

Mentions: Adrenomedullin (AM) is a peptide with 52 amino acids and has tyrosine amino acid at carboxy terminal. It plays a significant role in adverse effects and neuronal injury steps of significant hyperbilirubinemia [28]. In this study, there were statistically significant differences between the phenylhydrazine and control groups regarding AM levels (P < 0.001). Compared to phenylhydrazine group, ABE administration reduced AM levels in a dose-dependent manner (Table 4). In further analysis, there was a significant positive correlation between serum bilirubin levels and simultaneously measured serum AM levels (Figure 5).


Therapeutic effect of Agaricus brasiliensis on phenylhydrazine-induced neonatal jaundice in rats.

Zhang L, Yuan B, Wang H, Gao Y - Biomed Res Int (2015)

Correlation between serum AM levels and serum bilirubin levels.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4389989&req=5

fig5: Correlation between serum AM levels and serum bilirubin levels.
Mentions: Adrenomedullin (AM) is a peptide with 52 amino acids and has tyrosine amino acid at carboxy terminal. It plays a significant role in adverse effects and neuronal injury steps of significant hyperbilirubinemia [28]. In this study, there were statistically significant differences between the phenylhydrazine and control groups regarding AM levels (P < 0.001). Compared to phenylhydrazine group, ABE administration reduced AM levels in a dose-dependent manner (Table 4). In further analysis, there was a significant positive correlation between serum bilirubin levels and simultaneously measured serum AM levels (Figure 5).

Bottom Line: Administration of ABE dose-dependently reduced the elevated bilirubin level induced by phenylhydrazine.It can be somewhat supported from the results of in vitro bilirubin degradation experiment.ABE treatment also reduced the total antioxidant status (TAOS), cascade O2(-)/SOD, level of NF-κB protein, and adrenomedullin (AM).

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics, Second Hospital of Xi'an Jiaotong University, Xi'an 710004, China.

ABSTRACT
The present study was designed to investigate the effect of Agaricus brasiliensis extract (ABE) on phenylhydrazine-induced neonatal jaundice in rats. Administration of ABE dose-dependently reduced the elevated bilirubin level induced by phenylhydrazine. It can be somewhat supported from the results of in vitro bilirubin degradation experiment. ABE treatment also reduced the total antioxidant status (TAOS), cascade O2(-)/SOD, level of NF-κB protein, and adrenomedullin (AM). Overall, the results of this study demonstrated that Agaricus brasiliensis extract may be beneficial to reducing bilirubin level without causing hepatotoxicity in neonatal jaundice.

Show MeSH
Related in: MedlinePlus