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Therapeutic effect of Agaricus brasiliensis on phenylhydrazine-induced neonatal jaundice in rats.

Zhang L, Yuan B, Wang H, Gao Y - Biomed Res Int (2015)

Bottom Line: Administration of ABE dose-dependently reduced the elevated bilirubin level induced by phenylhydrazine.It can be somewhat supported from the results of in vitro bilirubin degradation experiment.ABE treatment also reduced the total antioxidant status (TAOS), cascade O2(-)/SOD, level of NF-κB protein, and adrenomedullin (AM).

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics, Second Hospital of Xi'an Jiaotong University, Xi'an 710004, China.

ABSTRACT
The present study was designed to investigate the effect of Agaricus brasiliensis extract (ABE) on phenylhydrazine-induced neonatal jaundice in rats. Administration of ABE dose-dependently reduced the elevated bilirubin level induced by phenylhydrazine. It can be somewhat supported from the results of in vitro bilirubin degradation experiment. ABE treatment also reduced the total antioxidant status (TAOS), cascade O2(-)/SOD, level of NF-κB protein, and adrenomedullin (AM). Overall, the results of this study demonstrated that Agaricus brasiliensis extract may be beneficial to reducing bilirubin level without causing hepatotoxicity in neonatal jaundice.

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Effect of ABE on protein expression of NF-κB. Values represent the mean ± SEM. *P < 0.05 versus phenylhydrazine group (Pdz: phenylhydrazine).
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fig4: Effect of ABE on protein expression of NF-κB. Values represent the mean ± SEM. *P < 0.05 versus phenylhydrazine group (Pdz: phenylhydrazine).

Mentions: An extreme high level of SUB elicits the release of proinflammatory cytokines, such as TNF-α and IL-1β, through the activation of NF-κB signaling pathways at the intracellular level [26, 27]. Substantially, hyperbilirubinemia induced a predominant increase in nuclear translocation of NF-κB (Figure 4(a)). As expected, level of NF-κB protein decreased in the nucleus of liver cells of ABE-100 group (Figure 4(b)). Data obtained from the treatment of rats with phenylhydrazine indicated that NF-κB played an important role in hyperbilirubinemia. The increased NF-κB protein expression was attenuated by ABE-100. It indicated that ABE performs its neonatal jaundice protective effect, at least partly, due to the regulation on NF-κB, which can further influence the release of proinflammatory cytokines.


Therapeutic effect of Agaricus brasiliensis on phenylhydrazine-induced neonatal jaundice in rats.

Zhang L, Yuan B, Wang H, Gao Y - Biomed Res Int (2015)

Effect of ABE on protein expression of NF-κB. Values represent the mean ± SEM. *P < 0.05 versus phenylhydrazine group (Pdz: phenylhydrazine).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4389989&req=5

fig4: Effect of ABE on protein expression of NF-κB. Values represent the mean ± SEM. *P < 0.05 versus phenylhydrazine group (Pdz: phenylhydrazine).
Mentions: An extreme high level of SUB elicits the release of proinflammatory cytokines, such as TNF-α and IL-1β, through the activation of NF-κB signaling pathways at the intracellular level [26, 27]. Substantially, hyperbilirubinemia induced a predominant increase in nuclear translocation of NF-κB (Figure 4(a)). As expected, level of NF-κB protein decreased in the nucleus of liver cells of ABE-100 group (Figure 4(b)). Data obtained from the treatment of rats with phenylhydrazine indicated that NF-κB played an important role in hyperbilirubinemia. The increased NF-κB protein expression was attenuated by ABE-100. It indicated that ABE performs its neonatal jaundice protective effect, at least partly, due to the regulation on NF-κB, which can further influence the release of proinflammatory cytokines.

Bottom Line: Administration of ABE dose-dependently reduced the elevated bilirubin level induced by phenylhydrazine.It can be somewhat supported from the results of in vitro bilirubin degradation experiment.ABE treatment also reduced the total antioxidant status (TAOS), cascade O2(-)/SOD, level of NF-κB protein, and adrenomedullin (AM).

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics, Second Hospital of Xi'an Jiaotong University, Xi'an 710004, China.

ABSTRACT
The present study was designed to investigate the effect of Agaricus brasiliensis extract (ABE) on phenylhydrazine-induced neonatal jaundice in rats. Administration of ABE dose-dependently reduced the elevated bilirubin level induced by phenylhydrazine. It can be somewhat supported from the results of in vitro bilirubin degradation experiment. ABE treatment also reduced the total antioxidant status (TAOS), cascade O2(-)/SOD, level of NF-κB protein, and adrenomedullin (AM). Overall, the results of this study demonstrated that Agaricus brasiliensis extract may be beneficial to reducing bilirubin level without causing hepatotoxicity in neonatal jaundice.

Show MeSH
Related in: MedlinePlus