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Therapeutic effect of Agaricus brasiliensis on phenylhydrazine-induced neonatal jaundice in rats.

Zhang L, Yuan B, Wang H, Gao Y - Biomed Res Int (2015)

Bottom Line: Administration of ABE dose-dependently reduced the elevated bilirubin level induced by phenylhydrazine.It can be somewhat supported from the results of in vitro bilirubin degradation experiment.ABE treatment also reduced the total antioxidant status (TAOS), cascade O2(-)/SOD, level of NF-κB protein, and adrenomedullin (AM).

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics, Second Hospital of Xi'an Jiaotong University, Xi'an 710004, China.

ABSTRACT
The present study was designed to investigate the effect of Agaricus brasiliensis extract (ABE) on phenylhydrazine-induced neonatal jaundice in rats. Administration of ABE dose-dependently reduced the elevated bilirubin level induced by phenylhydrazine. It can be somewhat supported from the results of in vitro bilirubin degradation experiment. ABE treatment also reduced the total antioxidant status (TAOS), cascade O2(-)/SOD, level of NF-κB protein, and adrenomedullin (AM). Overall, the results of this study demonstrated that Agaricus brasiliensis extract may be beneficial to reducing bilirubin level without causing hepatotoxicity in neonatal jaundice.

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Related in: MedlinePlus

Comparison of in vitro efficacy of bilirubin degradation between different concentrations of ABE. Values are shown as means ± SEM. *P < 0.05 versus control group, **P < 0.01 versus control group.
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fig1: Comparison of in vitro efficacy of bilirubin degradation between different concentrations of ABE. Values are shown as means ± SEM. *P < 0.05 versus control group, **P < 0.01 versus control group.

Mentions: Neonatal jaundice occurs in newborns as a result of excessive bilirubin formation and transient inability of the neonatal liver to clear bilirubin rapidly enough from the blood. Severe hyperbilirubinemia is toxic to the developing central nervous system [21]. Prolonged and uncontrolled high levels of bilirubin lead to bilirubin encephalopathy and subsequently kernicterus [22]. We used phenylhydrazine to induce nonhepatic neonatal hyperbilirubinemia in rats because it increased unconjugated bilirubin level. The bilirubin level was measured to evaluate the role of ABE in NJ. The serum STB levels in control group were found to be 0.4 ± 0.07 mg/dL. A significant increase in the serum STB in serum was observed in phenylhydrazine group, as compared to the control group (P < 0.01), whereas ABE decreased the STB and SUB levels significantly in a dose-dependent manner (Table 1). It can be somewhat supported from the results of in vitro bilirubin degradation experiment (Figure 1). Figure 1 shows the action of the ABE in bilirubin solution. Treatment of ABE shows a significantly higher efficacy of bilirubin gradation than the control group in in vitro experiment in a dose dependent manner. This result indicated that the effects of ABE on bilirubin gradation may be one of its important mechanisms in fighting neonatal jaundice.


Therapeutic effect of Agaricus brasiliensis on phenylhydrazine-induced neonatal jaundice in rats.

Zhang L, Yuan B, Wang H, Gao Y - Biomed Res Int (2015)

Comparison of in vitro efficacy of bilirubin degradation between different concentrations of ABE. Values are shown as means ± SEM. *P < 0.05 versus control group, **P < 0.01 versus control group.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4389989&req=5

fig1: Comparison of in vitro efficacy of bilirubin degradation between different concentrations of ABE. Values are shown as means ± SEM. *P < 0.05 versus control group, **P < 0.01 versus control group.
Mentions: Neonatal jaundice occurs in newborns as a result of excessive bilirubin formation and transient inability of the neonatal liver to clear bilirubin rapidly enough from the blood. Severe hyperbilirubinemia is toxic to the developing central nervous system [21]. Prolonged and uncontrolled high levels of bilirubin lead to bilirubin encephalopathy and subsequently kernicterus [22]. We used phenylhydrazine to induce nonhepatic neonatal hyperbilirubinemia in rats because it increased unconjugated bilirubin level. The bilirubin level was measured to evaluate the role of ABE in NJ. The serum STB levels in control group were found to be 0.4 ± 0.07 mg/dL. A significant increase in the serum STB in serum was observed in phenylhydrazine group, as compared to the control group (P < 0.01), whereas ABE decreased the STB and SUB levels significantly in a dose-dependent manner (Table 1). It can be somewhat supported from the results of in vitro bilirubin degradation experiment (Figure 1). Figure 1 shows the action of the ABE in bilirubin solution. Treatment of ABE shows a significantly higher efficacy of bilirubin gradation than the control group in in vitro experiment in a dose dependent manner. This result indicated that the effects of ABE on bilirubin gradation may be one of its important mechanisms in fighting neonatal jaundice.

Bottom Line: Administration of ABE dose-dependently reduced the elevated bilirubin level induced by phenylhydrazine.It can be somewhat supported from the results of in vitro bilirubin degradation experiment.ABE treatment also reduced the total antioxidant status (TAOS), cascade O2(-)/SOD, level of NF-κB protein, and adrenomedullin (AM).

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics, Second Hospital of Xi'an Jiaotong University, Xi'an 710004, China.

ABSTRACT
The present study was designed to investigate the effect of Agaricus brasiliensis extract (ABE) on phenylhydrazine-induced neonatal jaundice in rats. Administration of ABE dose-dependently reduced the elevated bilirubin level induced by phenylhydrazine. It can be somewhat supported from the results of in vitro bilirubin degradation experiment. ABE treatment also reduced the total antioxidant status (TAOS), cascade O2(-)/SOD, level of NF-κB protein, and adrenomedullin (AM). Overall, the results of this study demonstrated that Agaricus brasiliensis extract may be beneficial to reducing bilirubin level without causing hepatotoxicity in neonatal jaundice.

Show MeSH
Related in: MedlinePlus