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Impaired consciousness is linked to changes in effective connectivity of the posterior cingulate cortex within the default mode network.

Crone JS, Schurz M, Höller Y, Bergmann J, Monti M, Schmid E, Trinka E, Kronbichler M - Neuroimage (2015)

Bottom Line: The intrinsic connectivity of the default mode network has been associated with the level of consciousness in patients with severe brain injury.To better understand what aspect of this intrinsic architecture is linked to consciousness, we applied spectral dynamic causal modeling to assess effective connectivity within the default mode network in patients with disorders of consciousness.The resulting regions were then included as nodes in a spectral dynamic causal modeling analysis in order to assess how the causal interactions across these regions as well as the characteristics of neuronal fluctuations change with the level of consciousness.

View Article: PubMed Central - PubMed

Affiliation: Neuroscience Institute & Centre for Cognitive Neuroscience, Christian Doppler Klinik, Paracelsus Medical University, Salzburg, Austria; Centre for Cognitive Neuroscience & Department of Psychology, University of Salzburg, Salzburg, Austria; Department of Neurology, Christian Doppler Klinik, Paracelsus Medical University, Salzburg, Austria; Department of Psychology, University of CA Los Angeles, USA. Electronic address: j.crone@neurocognition.org.

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Significant correlation between behavioral responsiveness of patients and parameter estimates of the posterior cingulate cortex.(A) Significant correlation between behavioral responsiveness (CRS-R scores) and recurrent connectivity strength of the posterior cingulate cortex for patients in minimally conscious state (MCS) and patients in vegetative state (VS/UWS). (B) Significant correlation between CRS-R scores and amplitude of neuronal fluctuations of the posterior cingulate cortex. Correlations were performed using Spearman's Rho. The black confidence ellipse indicates correlation strength for both groups together. The red and blue confidence ellipses indicate correlation strength for each patient group, respectively.
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f0025: Significant correlation between behavioral responsiveness of patients and parameter estimates of the posterior cingulate cortex.(A) Significant correlation between behavioral responsiveness (CRS-R scores) and recurrent connectivity strength of the posterior cingulate cortex for patients in minimally conscious state (MCS) and patients in vegetative state (VS/UWS). (B) Significant correlation between CRS-R scores and amplitude of neuronal fluctuations of the posterior cingulate cortex. Correlations were performed using Spearman's Rho. The black confidence ellipse indicates correlation strength for both groups together. The red and blue confidence ellipses indicate correlation strength for each patient group, respectively.

Mentions: To further explore the relation of behavioral responsiveness and properties of effective connectivity in patients, a Spearman correlation (two-tailed) was calculated between the CRS-R scores and those values showing significant results in the ANOVA. All p-values were corrected for false-discovery rate. Recurrent connectivity in the PCC correlates positively with behavioral performance in patients (r = .48, p = 0.044). Moreover, the amplitude of neuronal fluctuations in the PCC correlates negatively with the CRS-R scores of each patient (r = − .58, p = 0.015). Fig. 5 displays the correlation over both groups and for each group separately. The overall significant correlation is reflected in the VS/UWS but not in the MCS group.


Impaired consciousness is linked to changes in effective connectivity of the posterior cingulate cortex within the default mode network.

Crone JS, Schurz M, Höller Y, Bergmann J, Monti M, Schmid E, Trinka E, Kronbichler M - Neuroimage (2015)

Significant correlation between behavioral responsiveness of patients and parameter estimates of the posterior cingulate cortex.(A) Significant correlation between behavioral responsiveness (CRS-R scores) and recurrent connectivity strength of the posterior cingulate cortex for patients in minimally conscious state (MCS) and patients in vegetative state (VS/UWS). (B) Significant correlation between CRS-R scores and amplitude of neuronal fluctuations of the posterior cingulate cortex. Correlations were performed using Spearman's Rho. The black confidence ellipse indicates correlation strength for both groups together. The red and blue confidence ellipses indicate correlation strength for each patient group, respectively.
© Copyright Policy - CC BY
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4389831&req=5

f0025: Significant correlation between behavioral responsiveness of patients and parameter estimates of the posterior cingulate cortex.(A) Significant correlation between behavioral responsiveness (CRS-R scores) and recurrent connectivity strength of the posterior cingulate cortex for patients in minimally conscious state (MCS) and patients in vegetative state (VS/UWS). (B) Significant correlation between CRS-R scores and amplitude of neuronal fluctuations of the posterior cingulate cortex. Correlations were performed using Spearman's Rho. The black confidence ellipse indicates correlation strength for both groups together. The red and blue confidence ellipses indicate correlation strength for each patient group, respectively.
Mentions: To further explore the relation of behavioral responsiveness and properties of effective connectivity in patients, a Spearman correlation (two-tailed) was calculated between the CRS-R scores and those values showing significant results in the ANOVA. All p-values were corrected for false-discovery rate. Recurrent connectivity in the PCC correlates positively with behavioral performance in patients (r = .48, p = 0.044). Moreover, the amplitude of neuronal fluctuations in the PCC correlates negatively with the CRS-R scores of each patient (r = − .58, p = 0.015). Fig. 5 displays the correlation over both groups and for each group separately. The overall significant correlation is reflected in the VS/UWS but not in the MCS group.

Bottom Line: The intrinsic connectivity of the default mode network has been associated with the level of consciousness in patients with severe brain injury.To better understand what aspect of this intrinsic architecture is linked to consciousness, we applied spectral dynamic causal modeling to assess effective connectivity within the default mode network in patients with disorders of consciousness.The resulting regions were then included as nodes in a spectral dynamic causal modeling analysis in order to assess how the causal interactions across these regions as well as the characteristics of neuronal fluctuations change with the level of consciousness.

View Article: PubMed Central - PubMed

Affiliation: Neuroscience Institute & Centre for Cognitive Neuroscience, Christian Doppler Klinik, Paracelsus Medical University, Salzburg, Austria; Centre for Cognitive Neuroscience & Department of Psychology, University of Salzburg, Salzburg, Austria; Department of Neurology, Christian Doppler Klinik, Paracelsus Medical University, Salzburg, Austria; Department of Psychology, University of CA Los Angeles, USA. Electronic address: j.crone@neurocognition.org.

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Related in: MedlinePlus