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Impaired consciousness is linked to changes in effective connectivity of the posterior cingulate cortex within the default mode network.

Crone JS, Schurz M, Höller Y, Bergmann J, Monti M, Schmid E, Trinka E, Kronbichler M - Neuroimage (2015)

Bottom Line: The intrinsic connectivity of the default mode network has been associated with the level of consciousness in patients with severe brain injury.To better understand what aspect of this intrinsic architecture is linked to consciousness, we applied spectral dynamic causal modeling to assess effective connectivity within the default mode network in patients with disorders of consciousness.The resulting regions were then included as nodes in a spectral dynamic causal modeling analysis in order to assess how the causal interactions across these regions as well as the characteristics of neuronal fluctuations change with the level of consciousness.

View Article: PubMed Central - PubMed

Affiliation: Neuroscience Institute & Centre for Cognitive Neuroscience, Christian Doppler Klinik, Paracelsus Medical University, Salzburg, Austria; Centre for Cognitive Neuroscience & Department of Psychology, University of Salzburg, Salzburg, Austria; Department of Neurology, Christian Doppler Klinik, Paracelsus Medical University, Salzburg, Austria; Department of Psychology, University of CA Los Angeles, USA. Electronic address: j.crone@neurocognition.org.

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Significant differences in parameter estimates between groups.(A) Significant differences between healthy controls (CON), patients in minimally conscious state (MCS) and patients in vegetative state (VS/UWS) in the strength of effective connectivity between the medial frontal cortex (MFC), the posterior cingulate cortex (PCC), the left inferior parietal lobule (lIPL), and the right inferior parietal lobule (rIPL). Red arrows indicate positive values, blue arrows indicate negative values for controls. Note that means for the recurrent connectivity strength are inhibitory with positive values indicating a stronger effect relative to prior. (B) Significant differences between groups in the amplitude of neuronal fluctuations of the posterior cingulate cortex. Bar-plots represent means and standard errors; all p-values are corrected for multiple comparisons.
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f0020: Significant differences in parameter estimates between groups.(A) Significant differences between healthy controls (CON), patients in minimally conscious state (MCS) and patients in vegetative state (VS/UWS) in the strength of effective connectivity between the medial frontal cortex (MFC), the posterior cingulate cortex (PCC), the left inferior parietal lobule (lIPL), and the right inferior parietal lobule (rIPL). Red arrows indicate positive values, blue arrows indicate negative values for controls. Note that means for the recurrent connectivity strength are inhibitory with positive values indicating a stronger effect relative to prior. (B) Significant differences between groups in the amplitude of neuronal fluctuations of the posterior cingulate cortex. Bar-plots represent means and standard errors; all p-values are corrected for multiple comparisons.

Mentions: Connectivity strength (DCM.Ep.A) as well as characteristics in the oscillation of neuronal fluctuations (DCM.Ep.a) were compared between groups using ANOVA permutation testing with additional post-hoc tests. Significant differences between groups in the connectivity strength are displayed in Fig. 4A. All reported p-values are corrected for false-discovery rate. In addition, please note that all significant results from the 24 ANOVAs performed with permutation testing were significant at p < 0.04151, thus, we expect less than 1 false positive (see Materials and methods section).


Impaired consciousness is linked to changes in effective connectivity of the posterior cingulate cortex within the default mode network.

Crone JS, Schurz M, Höller Y, Bergmann J, Monti M, Schmid E, Trinka E, Kronbichler M - Neuroimage (2015)

Significant differences in parameter estimates between groups.(A) Significant differences between healthy controls (CON), patients in minimally conscious state (MCS) and patients in vegetative state (VS/UWS) in the strength of effective connectivity between the medial frontal cortex (MFC), the posterior cingulate cortex (PCC), the left inferior parietal lobule (lIPL), and the right inferior parietal lobule (rIPL). Red arrows indicate positive values, blue arrows indicate negative values for controls. Note that means for the recurrent connectivity strength are inhibitory with positive values indicating a stronger effect relative to prior. (B) Significant differences between groups in the amplitude of neuronal fluctuations of the posterior cingulate cortex. Bar-plots represent means and standard errors; all p-values are corrected for multiple comparisons.
© Copyright Policy - CC BY
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4389831&req=5

f0020: Significant differences in parameter estimates between groups.(A) Significant differences between healthy controls (CON), patients in minimally conscious state (MCS) and patients in vegetative state (VS/UWS) in the strength of effective connectivity between the medial frontal cortex (MFC), the posterior cingulate cortex (PCC), the left inferior parietal lobule (lIPL), and the right inferior parietal lobule (rIPL). Red arrows indicate positive values, blue arrows indicate negative values for controls. Note that means for the recurrent connectivity strength are inhibitory with positive values indicating a stronger effect relative to prior. (B) Significant differences between groups in the amplitude of neuronal fluctuations of the posterior cingulate cortex. Bar-plots represent means and standard errors; all p-values are corrected for multiple comparisons.
Mentions: Connectivity strength (DCM.Ep.A) as well as characteristics in the oscillation of neuronal fluctuations (DCM.Ep.a) were compared between groups using ANOVA permutation testing with additional post-hoc tests. Significant differences between groups in the connectivity strength are displayed in Fig. 4A. All reported p-values are corrected for false-discovery rate. In addition, please note that all significant results from the 24 ANOVAs performed with permutation testing were significant at p < 0.04151, thus, we expect less than 1 false positive (see Materials and methods section).

Bottom Line: The intrinsic connectivity of the default mode network has been associated with the level of consciousness in patients with severe brain injury.To better understand what aspect of this intrinsic architecture is linked to consciousness, we applied spectral dynamic causal modeling to assess effective connectivity within the default mode network in patients with disorders of consciousness.The resulting regions were then included as nodes in a spectral dynamic causal modeling analysis in order to assess how the causal interactions across these regions as well as the characteristics of neuronal fluctuations change with the level of consciousness.

View Article: PubMed Central - PubMed

Affiliation: Neuroscience Institute & Centre for Cognitive Neuroscience, Christian Doppler Klinik, Paracelsus Medical University, Salzburg, Austria; Centre for Cognitive Neuroscience & Department of Psychology, University of Salzburg, Salzburg, Austria; Department of Neurology, Christian Doppler Klinik, Paracelsus Medical University, Salzburg, Austria; Department of Psychology, University of CA Los Angeles, USA. Electronic address: j.crone@neurocognition.org.

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Related in: MedlinePlus