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Impaired consciousness is linked to changes in effective connectivity of the posterior cingulate cortex within the default mode network.

Crone JS, Schurz M, Höller Y, Bergmann J, Monti M, Schmid E, Trinka E, Kronbichler M - Neuroimage (2015)

Bottom Line: The intrinsic connectivity of the default mode network has been associated with the level of consciousness in patients with severe brain injury.To better understand what aspect of this intrinsic architecture is linked to consciousness, we applied spectral dynamic causal modeling to assess effective connectivity within the default mode network in patients with disorders of consciousness.The resulting regions were then included as nodes in a spectral dynamic causal modeling analysis in order to assess how the causal interactions across these regions as well as the characteristics of neuronal fluctuations change with the level of consciousness.

View Article: PubMed Central - PubMed

Affiliation: Neuroscience Institute & Centre for Cognitive Neuroscience, Christian Doppler Klinik, Paracelsus Medical University, Salzburg, Austria; Centre for Cognitive Neuroscience & Department of Psychology, University of Salzburg, Salzburg, Austria; Department of Neurology, Christian Doppler Klinik, Paracelsus Medical University, Salzburg, Austria; Department of Psychology, University of CA Los Angeles, USA. Electronic address: j.crone@neurocognition.org.

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Significant connections within the full model in each group.Strength and direction of connectivity between the medial frontal cortex (MFC), the posterior cingulate cortex (PCC), the left inferior parietal lobule (lIPL), and the right inferior parietal lobule (rIPL) are displayed for healthy controls (CON), patients in minimally conscious state (MCS) and patients in vegetative state (VS/UWS). Red arrows and values indicate positive coupling, blue arrows and values indicate negative coupling. Gray values represent connections which did not differ significantly from zero in each group. In healthy volunteers, the PCC appears to be the main driven hub receiving positive input and giving negative feedback. In contrast, this pattern of interaction seems to be disrupted in patients.
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f0015: Significant connections within the full model in each group.Strength and direction of connectivity between the medial frontal cortex (MFC), the posterior cingulate cortex (PCC), the left inferior parietal lobule (lIPL), and the right inferior parietal lobule (rIPL) are displayed for healthy controls (CON), patients in minimally conscious state (MCS) and patients in vegetative state (VS/UWS). Red arrows and values indicate positive coupling, blue arrows and values indicate negative coupling. Gray values represent connections which did not differ significantly from zero in each group. In healthy volunteers, the PCC appears to be the main driven hub receiving positive input and giving negative feedback. In contrast, this pattern of interaction seems to be disrupted in patients.

Mentions: Fig. 3 displays the connectivity strength and direction of each connection between and within the four nodes for all three groups. Red and blue arrows (and values) represent those connections which are significantly different from zero in each group, while red arrows represent a positive connection strength and blue arrows a negative connection strength. Please note that the recurrent connectivity strength within each node, indicated with blue arrows, can have negative and positive values even though the connections strength is negative. This is because recurrent connections are assumed to always be inhibitory on biological constraints. In SPM12, the parameterization of the self-connections are log-scaled and the prior expectation is fixed at − 0.5 (with − 0.5 ∗ exp(A); where A has a prior mean of 0 and − 0.5 ∗ exp(0) = − 0.5). Consequently, a positive value means that the self-connection is more inhibitory and a negative value means that it is less inhibitory compared to the prior. In healthy controls, almost all reciprocal connections (except from the lateral IPL to the MFC) are significant. Interestingly, all driving influence from the PCC is negative. In patients, only a few connections within the full model are significant and none of the connections between nodes are negative.


Impaired consciousness is linked to changes in effective connectivity of the posterior cingulate cortex within the default mode network.

Crone JS, Schurz M, Höller Y, Bergmann J, Monti M, Schmid E, Trinka E, Kronbichler M - Neuroimage (2015)

Significant connections within the full model in each group.Strength and direction of connectivity between the medial frontal cortex (MFC), the posterior cingulate cortex (PCC), the left inferior parietal lobule (lIPL), and the right inferior parietal lobule (rIPL) are displayed for healthy controls (CON), patients in minimally conscious state (MCS) and patients in vegetative state (VS/UWS). Red arrows and values indicate positive coupling, blue arrows and values indicate negative coupling. Gray values represent connections which did not differ significantly from zero in each group. In healthy volunteers, the PCC appears to be the main driven hub receiving positive input and giving negative feedback. In contrast, this pattern of interaction seems to be disrupted in patients.
© Copyright Policy - CC BY
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4389831&req=5

f0015: Significant connections within the full model in each group.Strength and direction of connectivity between the medial frontal cortex (MFC), the posterior cingulate cortex (PCC), the left inferior parietal lobule (lIPL), and the right inferior parietal lobule (rIPL) are displayed for healthy controls (CON), patients in minimally conscious state (MCS) and patients in vegetative state (VS/UWS). Red arrows and values indicate positive coupling, blue arrows and values indicate negative coupling. Gray values represent connections which did not differ significantly from zero in each group. In healthy volunteers, the PCC appears to be the main driven hub receiving positive input and giving negative feedback. In contrast, this pattern of interaction seems to be disrupted in patients.
Mentions: Fig. 3 displays the connectivity strength and direction of each connection between and within the four nodes for all three groups. Red and blue arrows (and values) represent those connections which are significantly different from zero in each group, while red arrows represent a positive connection strength and blue arrows a negative connection strength. Please note that the recurrent connectivity strength within each node, indicated with blue arrows, can have negative and positive values even though the connections strength is negative. This is because recurrent connections are assumed to always be inhibitory on biological constraints. In SPM12, the parameterization of the self-connections are log-scaled and the prior expectation is fixed at − 0.5 (with − 0.5 ∗ exp(A); where A has a prior mean of 0 and − 0.5 ∗ exp(0) = − 0.5). Consequently, a positive value means that the self-connection is more inhibitory and a negative value means that it is less inhibitory compared to the prior. In healthy controls, almost all reciprocal connections (except from the lateral IPL to the MFC) are significant. Interestingly, all driving influence from the PCC is negative. In patients, only a few connections within the full model are significant and none of the connections between nodes are negative.

Bottom Line: The intrinsic connectivity of the default mode network has been associated with the level of consciousness in patients with severe brain injury.To better understand what aspect of this intrinsic architecture is linked to consciousness, we applied spectral dynamic causal modeling to assess effective connectivity within the default mode network in patients with disorders of consciousness.The resulting regions were then included as nodes in a spectral dynamic causal modeling analysis in order to assess how the causal interactions across these regions as well as the characteristics of neuronal fluctuations change with the level of consciousness.

View Article: PubMed Central - PubMed

Affiliation: Neuroscience Institute & Centre for Cognitive Neuroscience, Christian Doppler Klinik, Paracelsus Medical University, Salzburg, Austria; Centre for Cognitive Neuroscience & Department of Psychology, University of Salzburg, Salzburg, Austria; Department of Neurology, Christian Doppler Klinik, Paracelsus Medical University, Salzburg, Austria; Department of Psychology, University of CA Los Angeles, USA. Electronic address: j.crone@neurocognition.org.

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Related in: MedlinePlus