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Impaired consciousness is linked to changes in effective connectivity of the posterior cingulate cortex within the default mode network.

Crone JS, Schurz M, Höller Y, Bergmann J, Monti M, Schmid E, Trinka E, Kronbichler M - Neuroimage (2015)

Bottom Line: The intrinsic connectivity of the default mode network has been associated with the level of consciousness in patients with severe brain injury.To better understand what aspect of this intrinsic architecture is linked to consciousness, we applied spectral dynamic causal modeling to assess effective connectivity within the default mode network in patients with disorders of consciousness.The resulting regions were then included as nodes in a spectral dynamic causal modeling analysis in order to assess how the causal interactions across these regions as well as the characteristics of neuronal fluctuations change with the level of consciousness.

View Article: PubMed Central - PubMed

Affiliation: Neuroscience Institute & Centre for Cognitive Neuroscience, Christian Doppler Klinik, Paracelsus Medical University, Salzburg, Austria; Centre for Cognitive Neuroscience & Department of Psychology, University of Salzburg, Salzburg, Austria; Department of Neurology, Christian Doppler Klinik, Paracelsus Medical University, Salzburg, Austria; Department of Psychology, University of CA Los Angeles, USA. Electronic address: j.crone@neurocognition.org.

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Schematic representation of the fully and reciprocally connected model.All possible connections are displayed between the medial frontal cortex (MFC), the posterior cingulate cortex (PCC), the left inferior parietal lobule (lIPL), and the right inferior parietal lobule (rIPL).
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f0005: Schematic representation of the fully and reciprocally connected model.All possible connections are displayed between the medial frontal cortex (MFC), the posterior cingulate cortex (PCC), the left inferior parietal lobule (lIPL), and the right inferior parietal lobule (rIPL).

Mentions: DCM was performed by following the steps detailed below: (1) extraction of BOLD fMRI time series from each subject using the individual coordinates; (2) specification of the model space based on a fully and reciprocally connected model (see Fig. 1); (3) estimation of the specified model; (4) implementation of a post-hoc model selection routine.


Impaired consciousness is linked to changes in effective connectivity of the posterior cingulate cortex within the default mode network.

Crone JS, Schurz M, Höller Y, Bergmann J, Monti M, Schmid E, Trinka E, Kronbichler M - Neuroimage (2015)

Schematic representation of the fully and reciprocally connected model.All possible connections are displayed between the medial frontal cortex (MFC), the posterior cingulate cortex (PCC), the left inferior parietal lobule (lIPL), and the right inferior parietal lobule (rIPL).
© Copyright Policy - CC BY
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4389831&req=5

f0005: Schematic representation of the fully and reciprocally connected model.All possible connections are displayed between the medial frontal cortex (MFC), the posterior cingulate cortex (PCC), the left inferior parietal lobule (lIPL), and the right inferior parietal lobule (rIPL).
Mentions: DCM was performed by following the steps detailed below: (1) extraction of BOLD fMRI time series from each subject using the individual coordinates; (2) specification of the model space based on a fully and reciprocally connected model (see Fig. 1); (3) estimation of the specified model; (4) implementation of a post-hoc model selection routine.

Bottom Line: The intrinsic connectivity of the default mode network has been associated with the level of consciousness in patients with severe brain injury.To better understand what aspect of this intrinsic architecture is linked to consciousness, we applied spectral dynamic causal modeling to assess effective connectivity within the default mode network in patients with disorders of consciousness.The resulting regions were then included as nodes in a spectral dynamic causal modeling analysis in order to assess how the causal interactions across these regions as well as the characteristics of neuronal fluctuations change with the level of consciousness.

View Article: PubMed Central - PubMed

Affiliation: Neuroscience Institute & Centre for Cognitive Neuroscience, Christian Doppler Klinik, Paracelsus Medical University, Salzburg, Austria; Centre for Cognitive Neuroscience & Department of Psychology, University of Salzburg, Salzburg, Austria; Department of Neurology, Christian Doppler Klinik, Paracelsus Medical University, Salzburg, Austria; Department of Psychology, University of CA Los Angeles, USA. Electronic address: j.crone@neurocognition.org.

Show MeSH
Related in: MedlinePlus