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Luminal B subtype: a key factor for the worse prognosis of young breast cancer patients in China.

Tang LC, Jin X, Yang HY, He M, Chang H, Shao ZM, Di GH - BMC Cancer (2015)

Bottom Line: More grade III tumors and more lymph-vascular invasions (P < 0.01) were presented in <40y group when compared with 40-50y group.Younger patients with tumors of both Luminal A and Luminal B types were at increased risk for worse DFS (P = 0.03, HR = 1.69, 95% CI = 1.05-2.72; P < 0.01, HR = 3.61, 95% CI = 2.50-5.22) when compared with the older patients.Luminal B subtype may have a negative effect on the prognosis of young patients in China which should be validated further.

View Article: PubMed Central - PubMed

Affiliation: Department of Breast Surgery, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China. forever_drawer@163.com.

ABSTRACT

Background: The prognoses of young breast cancer patients are poor. The purpose of this study is to evaluate the different characteristics and prognoses among different subtypes of young breast cancer patients.

Methods: The study included 1360 patients <40 years-old (y) and 3110 patients 40-50y with operable breast cancer in Shanghai Cancer Center, Fudan University. The characteristics, overall survival (OS) and disease-free survival (DFS) were compared.

Results: The median follow-up was 54.1 months. More grade III tumors and more lymph-vascular invasions (P < 0.01) were presented in <40y group when compared with 40-50y group. More patients <40y presented with Luminal B (25.3% vs. 17.5%, P < 0.01) and triple negative (16.7% vs. 13.4%, P < 0.05) breast cancer while fewer had Luminal A tumor (48.5% vs. 59.2%, P < 0.01). Younger patients with tumors of both Luminal A and Luminal B types were at increased risk for worse DFS (P = 0.03, HR = 1.69, 95% CI = 1.05-2.72; P < 0.01, HR = 3.61, 95% CI = 2.50-5.22) when compared with the older patients. Patients <40y with Luminal B tumor had a two point five fold higher risk of death compared with older counterparts (P < 0.01, HR = 2.54, 95% CI = 1.35-4.79), however, a worse overall survival rate was not observed in the younger women with Luminal A breast cancer (P > 0.05). In multivariate analysis, Luminal B subtype was also a strong predictor of disease relapse (HR = 1.09, 95% CI = 1.01 to 1.19, P < 0.01) in younger patients with Luminal subtype tumors.

Conclusion: Characteristics of breast cancer suggested a more aggressive biology in Chinese patients with breast cancer diagnosed at young age. Luminal B subtype may have a negative effect on the prognosis of young patients in China which should be validated further.

No MeSH data available.


Related in: MedlinePlus

Overall survival (A) and disease-free survival (B) of <40y group vs. 41-50y group. *Adjusted for tumor size (≤5 cm v >5 cm) and lymph node status. HR, hazard ratio.
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Fig2: Overall survival (A) and disease-free survival (B) of <40y group vs. 41-50y group. *Adjusted for tumor size (≤5 cm v >5 cm) and lymph node status. HR, hazard ratio.

Mentions: The median follow-up of the reported patients was 54.1 months (58.8 months for <40y group vs. 50.5 months for 40-51y group). The 5y DFS was 72% vs. 83% (P < 0.01) and the 5y OS was 87% vs. 93% (P < 0.01), in favour of patients in the 40-50y group (Figure 2A,B).Figure 2


Luminal B subtype: a key factor for the worse prognosis of young breast cancer patients in China.

Tang LC, Jin X, Yang HY, He M, Chang H, Shao ZM, Di GH - BMC Cancer (2015)

Overall survival (A) and disease-free survival (B) of <40y group vs. 41-50y group. *Adjusted for tumor size (≤5 cm v >5 cm) and lymph node status. HR, hazard ratio.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4389816&req=5

Fig2: Overall survival (A) and disease-free survival (B) of <40y group vs. 41-50y group. *Adjusted for tumor size (≤5 cm v >5 cm) and lymph node status. HR, hazard ratio.
Mentions: The median follow-up of the reported patients was 54.1 months (58.8 months for <40y group vs. 50.5 months for 40-51y group). The 5y DFS was 72% vs. 83% (P < 0.01) and the 5y OS was 87% vs. 93% (P < 0.01), in favour of patients in the 40-50y group (Figure 2A,B).Figure 2

Bottom Line: More grade III tumors and more lymph-vascular invasions (P < 0.01) were presented in <40y group when compared with 40-50y group.Younger patients with tumors of both Luminal A and Luminal B types were at increased risk for worse DFS (P = 0.03, HR = 1.69, 95% CI = 1.05-2.72; P < 0.01, HR = 3.61, 95% CI = 2.50-5.22) when compared with the older patients.Luminal B subtype may have a negative effect on the prognosis of young patients in China which should be validated further.

View Article: PubMed Central - PubMed

Affiliation: Department of Breast Surgery, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China. forever_drawer@163.com.

ABSTRACT

Background: The prognoses of young breast cancer patients are poor. The purpose of this study is to evaluate the different characteristics and prognoses among different subtypes of young breast cancer patients.

Methods: The study included 1360 patients <40 years-old (y) and 3110 patients 40-50y with operable breast cancer in Shanghai Cancer Center, Fudan University. The characteristics, overall survival (OS) and disease-free survival (DFS) were compared.

Results: The median follow-up was 54.1 months. More grade III tumors and more lymph-vascular invasions (P < 0.01) were presented in <40y group when compared with 40-50y group. More patients <40y presented with Luminal B (25.3% vs. 17.5%, P < 0.01) and triple negative (16.7% vs. 13.4%, P < 0.05) breast cancer while fewer had Luminal A tumor (48.5% vs. 59.2%, P < 0.01). Younger patients with tumors of both Luminal A and Luminal B types were at increased risk for worse DFS (P = 0.03, HR = 1.69, 95% CI = 1.05-2.72; P < 0.01, HR = 3.61, 95% CI = 2.50-5.22) when compared with the older patients. Patients <40y with Luminal B tumor had a two point five fold higher risk of death compared with older counterparts (P < 0.01, HR = 2.54, 95% CI = 1.35-4.79), however, a worse overall survival rate was not observed in the younger women with Luminal A breast cancer (P > 0.05). In multivariate analysis, Luminal B subtype was also a strong predictor of disease relapse (HR = 1.09, 95% CI = 1.01 to 1.19, P < 0.01) in younger patients with Luminal subtype tumors.

Conclusion: Characteristics of breast cancer suggested a more aggressive biology in Chinese patients with breast cancer diagnosed at young age. Luminal B subtype may have a negative effect on the prognosis of young patients in China which should be validated further.

No MeSH data available.


Related in: MedlinePlus