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A photochromic sensor microchip for high-performance multiplex metal ions detection.

Huang Y, Li F, Ye C, Qin M, Ran W, Song Y - Sci Rep (2015)

Bottom Line: It is expected to develop new principles and techniques to achieve high-performance multi-analytes testing with facile sensors.The multi-testing sensor array performed in dark, ultraviolet or visual stimulation, corresponding to different molecular states of spirooxazine metal ions coordination.The facile photochromic microchip contributes a multi-states array sensing method, and will open new opportunities for the development of advanced discriminant analysis for complex analytes.

View Article: PubMed Central - PubMed

Affiliation: Key Laboratory of Green Printing, Institute of Chemistry, Chinese Academy of Sciences.

ABSTRACT
Current multi-analytes chips are limited with requiring numbers of sensors, complex synthesis and compounds screen. It is expected to develop new principles and techniques to achieve high-performance multi-analytes testing with facile sensors. Here, we investigated the correlative multi-states properties of a photochromic sensor (spirooxazine), which is capable of a selective and cross-reactive sensor array for discriminated multi-analytes (11 metal ions) detection by just one sensing compound. The multi-testing sensor array performed in dark, ultraviolet or visual stimulation, corresponding to different molecular states of spirooxazine metal ions coordination. The facile photochromic microchip contributes a multi-states array sensing method, and will open new opportunities for the development of advanced discriminant analysis for complex analytes.

No MeSH data available.


LDA score plot corresponding to the response of the SP microchip to 16 kinds of natural mineral water comes from various countries.The data set contains 16 brands and 1 control, 15 trials each. LDA shows 100% correct classification for all water brands.
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f6: LDA score plot corresponding to the response of the SP microchip to 16 kinds of natural mineral water comes from various countries.The data set contains 16 brands and 1 control, 15 trials each. LDA shows 100% correct classification for all water brands.

Mentions: Encouraged by the results above, we explored the utility of the spirooxazine multi-states sensor array by exploring a potential application: identification of mineral and purified water (Milli-Q water) based on their cation content as shown in Fig. 6. Table 1 lists Ca2+ and Mg2+ contents for all of the mineral water brands. The pH levels of most brands are in the range of 6–7.8 (except the Sourcy pure red with pH = 4.7), where the sensor array presents a rather flat response. The list is clear that all 16 commercial potable water samples contain different concentrations of cations. LDA analysis shows a complete and clear 100% correct classification for all 255 trials (Figure S6). The study demonstrates that the photochromic SP microchip detection of metal ions can be generated into metal ions mixtures. Furthermore, we also processed the photochromic SP microchip for detecting metal ions in human serum (protein removed), and the LDA result displays 100% classification accuracy (Fig. S2, Table S7). The result suggests its potential applications in complex physiological environment.


A photochromic sensor microchip for high-performance multiplex metal ions detection.

Huang Y, Li F, Ye C, Qin M, Ran W, Song Y - Sci Rep (2015)

LDA score plot corresponding to the response of the SP microchip to 16 kinds of natural mineral water comes from various countries.The data set contains 16 brands and 1 control, 15 trials each. LDA shows 100% correct classification for all water brands.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4389811&req=5

f6: LDA score plot corresponding to the response of the SP microchip to 16 kinds of natural mineral water comes from various countries.The data set contains 16 brands and 1 control, 15 trials each. LDA shows 100% correct classification for all water brands.
Mentions: Encouraged by the results above, we explored the utility of the spirooxazine multi-states sensor array by exploring a potential application: identification of mineral and purified water (Milli-Q water) based on their cation content as shown in Fig. 6. Table 1 lists Ca2+ and Mg2+ contents for all of the mineral water brands. The pH levels of most brands are in the range of 6–7.8 (except the Sourcy pure red with pH = 4.7), where the sensor array presents a rather flat response. The list is clear that all 16 commercial potable water samples contain different concentrations of cations. LDA analysis shows a complete and clear 100% correct classification for all 255 trials (Figure S6). The study demonstrates that the photochromic SP microchip detection of metal ions can be generated into metal ions mixtures. Furthermore, we also processed the photochromic SP microchip for detecting metal ions in human serum (protein removed), and the LDA result displays 100% classification accuracy (Fig. S2, Table S7). The result suggests its potential applications in complex physiological environment.

Bottom Line: It is expected to develop new principles and techniques to achieve high-performance multi-analytes testing with facile sensors.The multi-testing sensor array performed in dark, ultraviolet or visual stimulation, corresponding to different molecular states of spirooxazine metal ions coordination.The facile photochromic microchip contributes a multi-states array sensing method, and will open new opportunities for the development of advanced discriminant analysis for complex analytes.

View Article: PubMed Central - PubMed

Affiliation: Key Laboratory of Green Printing, Institute of Chemistry, Chinese Academy of Sciences.

ABSTRACT
Current multi-analytes chips are limited with requiring numbers of sensors, complex synthesis and compounds screen. It is expected to develop new principles and techniques to achieve high-performance multi-analytes testing with facile sensors. Here, we investigated the correlative multi-states properties of a photochromic sensor (spirooxazine), which is capable of a selective and cross-reactive sensor array for discriminated multi-analytes (11 metal ions) detection by just one sensing compound. The multi-testing sensor array performed in dark, ultraviolet or visual stimulation, corresponding to different molecular states of spirooxazine metal ions coordination. The facile photochromic microchip contributes a multi-states array sensing method, and will open new opportunities for the development of advanced discriminant analysis for complex analytes.

No MeSH data available.