Limits...
Screening tests: a review with examples.

Maxim LD, Niebo R, Utell MJ - Inhal Toxicol (2014)

Bottom Line: This article presents an overview of such tests including the definitions of key technical (sensitivity and specificity) and population characteristics necessary to assess the benefits and limitations of such tests.The importance of careful consideration of the consequences of both false positives and negatives is highlighted.Receiver operating characteristic curves are explained as is the need to carefully select the population group to be tested.

View Article: PubMed Central - PubMed

Affiliation: Everest Consulting Associates , Cranbury, NJ , USA and.

ABSTRACT
Screening tests are widely used in medicine to assess the likelihood that members of a defined population have a particular disease. This article presents an overview of such tests including the definitions of key technical (sensitivity and specificity) and population characteristics necessary to assess the benefits and limitations of such tests. Several examples are used to illustrate calculations, including the characteristics of low dose computed tomography as a lung cancer screen, choice of an optimal PSA cutoff and selection of the population to undergo mammography. The importance of careful consideration of the consequences of both false positives and negatives is highlighted. Receiver operating characteristic curves are explained as is the need to carefully select the population group to be tested.

Show MeSH
Receiver operating characteristic curves of prostate specific antigen (PSA) test, based on data from Thompson et al. (2005) among men aged 70 or more (AUC = 0.678). The top curve uses a combined PSA and Gleason Grade > 8 score (AUC = 0.827). The bottom curve is what would be expected by chance alone (AUC = 0.50).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4389712&req=5

Figure 7: Receiver operating characteristic curves of prostate specific antigen (PSA) test, based on data from Thompson et al. (2005) among men aged 70 or more (AUC = 0.678). The top curve uses a combined PSA and Gleason Grade > 8 score (AUC = 0.827). The bottom curve is what would be expected by chance alone (AUC = 0.50).

Mentions: Thompson et al. (2005) also considered using a so-called Gleason score17 with a cutoff of 8 or more in this population. Figure 7 shows the ROC curve (topmost curve) for this possible screening test. As can be seen, this series of tests dominates the tests based upon PSA score alone (the AUC in this case is 0.827). The dashed line in Figure 7 shows the ROC curve that would occur under chance alone.


Screening tests: a review with examples.

Maxim LD, Niebo R, Utell MJ - Inhal Toxicol (2014)

Receiver operating characteristic curves of prostate specific antigen (PSA) test, based on data from Thompson et al. (2005) among men aged 70 or more (AUC = 0.678). The top curve uses a combined PSA and Gleason Grade > 8 score (AUC = 0.827). The bottom curve is what would be expected by chance alone (AUC = 0.50).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4389712&req=5

Figure 7: Receiver operating characteristic curves of prostate specific antigen (PSA) test, based on data from Thompson et al. (2005) among men aged 70 or more (AUC = 0.678). The top curve uses a combined PSA and Gleason Grade > 8 score (AUC = 0.827). The bottom curve is what would be expected by chance alone (AUC = 0.50).
Mentions: Thompson et al. (2005) also considered using a so-called Gleason score17 with a cutoff of 8 or more in this population. Figure 7 shows the ROC curve (topmost curve) for this possible screening test. As can be seen, this series of tests dominates the tests based upon PSA score alone (the AUC in this case is 0.827). The dashed line in Figure 7 shows the ROC curve that would occur under chance alone.

Bottom Line: This article presents an overview of such tests including the definitions of key technical (sensitivity and specificity) and population characteristics necessary to assess the benefits and limitations of such tests.The importance of careful consideration of the consequences of both false positives and negatives is highlighted.Receiver operating characteristic curves are explained as is the need to carefully select the population group to be tested.

View Article: PubMed Central - PubMed

Affiliation: Everest Consulting Associates , Cranbury, NJ , USA and.

ABSTRACT
Screening tests are widely used in medicine to assess the likelihood that members of a defined population have a particular disease. This article presents an overview of such tests including the definitions of key technical (sensitivity and specificity) and population characteristics necessary to assess the benefits and limitations of such tests. Several examples are used to illustrate calculations, including the characteristics of low dose computed tomography as a lung cancer screen, choice of an optimal PSA cutoff and selection of the population to undergo mammography. The importance of careful consideration of the consequences of both false positives and negatives is highlighted. Receiver operating characteristic curves are explained as is the need to carefully select the population group to be tested.

Show MeSH