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Efficacy of phytoestrogens for menopausal symptoms: a meta-analysis and systematic review.

Chen MN, Lin CC, Liu CF - Climacteric (2014)

Bottom Line: Meta-analysis of the seven studies that reported KI data indicated no significant treatment effect of phytoestrogen as compared to placebo (pooled mean difference = 6.44, p = 0.110).Meta-analysis of the ten studies that reported hot flush data indicated that phytoestrogens result in a significantly greater reduction in hot flush frequency compared to placebo (pooled mean difference = 0.89, p < 0.005).Phytoestrogens appear to reduce the frequency of hot flushes in menopausal women, without serious side-effects.

View Article: PubMed Central - PubMed

Affiliation: Hsin Sheng Junior College of Medical Care and Management , Taoyuan.

ABSTRACT

Objective: To perform a meta-analysis examining the efficacy of phytoestrogens for the relief of menopausal symptoms.

Methods: Medline, Cochrane, EMBASE, and Google Scholar databases were searched until September 30, 2013 using the following key words: vasomotor symptoms, menopausal symptoms, phytoestrogens, isoflavones, coumestrol, soy, red clover. Inclusion criteria were (1) randomized controlled trial (RCT), (2) perimenopausal or postmenopausal women experiencing menopausal symptoms, (3) intervention with an oral phytoestrogen. Outcome measures included Kupperman index (KI) changes, daily hot flush frequency, and the likelihood of side-effects.

Results: Of 543 potentially relevant studies identified, 15 RCTs meeting the inclusion criteria were included. The mean age of the subjects ranged from 49 to 58.3 and 48 to 60.1 years, respectively, in the placebo and phytoestrogen groups. The number of participants ranged from 30 to 252, and the intervention periods ranged from 3 to 12 months. Meta-analysis of the seven studies that reported KI data indicated no significant treatment effect of phytoestrogen as compared to placebo (pooled mean difference = 6.44, p = 0.110). Meta-analysis of the ten studies that reported hot flush data indicated that phytoestrogens result in a significantly greater reduction in hot flush frequency compared to placebo (pooled mean difference = 0.89, p < 0.005). Meta-analysis of the five studies that reported side-effect data showed no significant difference between the two groups (p = 0.175).

Conclusion: Phytoestrogens appear to reduce the frequency of hot flushes in menopausal women, without serious side-effects.

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Related in: MedlinePlus

Evaluation of publication bias for (a) Kupperman index, (b) hot flush frequency, and (c) side-effects
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Figure 5: Evaluation of publication bias for (a) Kupperman index, (b) hot flush frequency, and (c) side-effects

Mentions: Egger's test for KI (seven studies)17–20,23–25 showed the estimated intercept to be −10.01, with a one-tailed p value = 0.043, which indicated a significant asymmetry in the funnel plot (Figure 5a). Egger's test for hot flush frequency (ten studies)11,15,16,19,21–23,26–28 showed the estimated intercept to be 2.99, with a one-tailed p value = 0.036, which indicated a significant asymmetry in the funnel plot (Figure 5b). Egger's test for side-effects (five studies)19,21,23,26,28 showed the estimated intercept to be −1.92 with one-tailed p value of 0.185 (non-significant) which indicated no significant asymmetry in the funnel plot (Figure 5c).


Efficacy of phytoestrogens for menopausal symptoms: a meta-analysis and systematic review.

Chen MN, Lin CC, Liu CF - Climacteric (2014)

Evaluation of publication bias for (a) Kupperman index, (b) hot flush frequency, and (c) side-effects
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4389700&req=5

Figure 5: Evaluation of publication bias for (a) Kupperman index, (b) hot flush frequency, and (c) side-effects
Mentions: Egger's test for KI (seven studies)17–20,23–25 showed the estimated intercept to be −10.01, with a one-tailed p value = 0.043, which indicated a significant asymmetry in the funnel plot (Figure 5a). Egger's test for hot flush frequency (ten studies)11,15,16,19,21–23,26–28 showed the estimated intercept to be 2.99, with a one-tailed p value = 0.036, which indicated a significant asymmetry in the funnel plot (Figure 5b). Egger's test for side-effects (five studies)19,21,23,26,28 showed the estimated intercept to be −1.92 with one-tailed p value of 0.185 (non-significant) which indicated no significant asymmetry in the funnel plot (Figure 5c).

Bottom Line: Meta-analysis of the seven studies that reported KI data indicated no significant treatment effect of phytoestrogen as compared to placebo (pooled mean difference = 6.44, p = 0.110).Meta-analysis of the ten studies that reported hot flush data indicated that phytoestrogens result in a significantly greater reduction in hot flush frequency compared to placebo (pooled mean difference = 0.89, p < 0.005).Phytoestrogens appear to reduce the frequency of hot flushes in menopausal women, without serious side-effects.

View Article: PubMed Central - PubMed

Affiliation: Hsin Sheng Junior College of Medical Care and Management , Taoyuan.

ABSTRACT

Objective: To perform a meta-analysis examining the efficacy of phytoestrogens for the relief of menopausal symptoms.

Methods: Medline, Cochrane, EMBASE, and Google Scholar databases were searched until September 30, 2013 using the following key words: vasomotor symptoms, menopausal symptoms, phytoestrogens, isoflavones, coumestrol, soy, red clover. Inclusion criteria were (1) randomized controlled trial (RCT), (2) perimenopausal or postmenopausal women experiencing menopausal symptoms, (3) intervention with an oral phytoestrogen. Outcome measures included Kupperman index (KI) changes, daily hot flush frequency, and the likelihood of side-effects.

Results: Of 543 potentially relevant studies identified, 15 RCTs meeting the inclusion criteria were included. The mean age of the subjects ranged from 49 to 58.3 and 48 to 60.1 years, respectively, in the placebo and phytoestrogen groups. The number of participants ranged from 30 to 252, and the intervention periods ranged from 3 to 12 months. Meta-analysis of the seven studies that reported KI data indicated no significant treatment effect of phytoestrogen as compared to placebo (pooled mean difference = 6.44, p = 0.110). Meta-analysis of the ten studies that reported hot flush data indicated that phytoestrogens result in a significantly greater reduction in hot flush frequency compared to placebo (pooled mean difference = 0.89, p < 0.005). Meta-analysis of the five studies that reported side-effect data showed no significant difference between the two groups (p = 0.175).

Conclusion: Phytoestrogens appear to reduce the frequency of hot flushes in menopausal women, without serious side-effects.

Show MeSH
Related in: MedlinePlus