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Efficacy of phytoestrogens for menopausal symptoms: a meta-analysis and systematic review.

Chen MN, Lin CC, Liu CF - Climacteric (2014)

Bottom Line: Meta-analysis of the seven studies that reported KI data indicated no significant treatment effect of phytoestrogen as compared to placebo (pooled mean difference = 6.44, p = 0.110).Meta-analysis of the ten studies that reported hot flush data indicated that phytoestrogens result in a significantly greater reduction in hot flush frequency compared to placebo (pooled mean difference = 0.89, p < 0.005).Phytoestrogens appear to reduce the frequency of hot flushes in menopausal women, without serious side-effects.

View Article: PubMed Central - PubMed

Affiliation: Hsin Sheng Junior College of Medical Care and Management , Taoyuan.

ABSTRACT

Objective: To perform a meta-analysis examining the efficacy of phytoestrogens for the relief of menopausal symptoms.

Methods: Medline, Cochrane, EMBASE, and Google Scholar databases were searched until September 30, 2013 using the following key words: vasomotor symptoms, menopausal symptoms, phytoestrogens, isoflavones, coumestrol, soy, red clover. Inclusion criteria were (1) randomized controlled trial (RCT), (2) perimenopausal or postmenopausal women experiencing menopausal symptoms, (3) intervention with an oral phytoestrogen. Outcome measures included Kupperman index (KI) changes, daily hot flush frequency, and the likelihood of side-effects.

Results: Of 543 potentially relevant studies identified, 15 RCTs meeting the inclusion criteria were included. The mean age of the subjects ranged from 49 to 58.3 and 48 to 60.1 years, respectively, in the placebo and phytoestrogen groups. The number of participants ranged from 30 to 252, and the intervention periods ranged from 3 to 12 months. Meta-analysis of the seven studies that reported KI data indicated no significant treatment effect of phytoestrogen as compared to placebo (pooled mean difference = 6.44, p = 0.110). Meta-analysis of the ten studies that reported hot flush data indicated that phytoestrogens result in a significantly greater reduction in hot flush frequency compared to placebo (pooled mean difference = 0.89, p < 0.005). Meta-analysis of the five studies that reported side-effect data showed no significant difference between the two groups (p = 0.175).

Conclusion: Phytoestrogens appear to reduce the frequency of hot flushes in menopausal women, without serious side-effects.

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Related in: MedlinePlus

Flow diagram of study selection
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Figure 1: Flow diagram of study selection

Mentions: A flow diagram of study selection is shown in Figure 1. A total of 543 potentially relevant articles were initially identified and screened, and 488 of them were subsequently excluded. Of the 55 full-text articles reviewed, 40 were excluded and ultimately 15 studies11,15–28 were included in the meta-analysis.


Efficacy of phytoestrogens for menopausal symptoms: a meta-analysis and systematic review.

Chen MN, Lin CC, Liu CF - Climacteric (2014)

Flow diagram of study selection
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4389700&req=5

Figure 1: Flow diagram of study selection
Mentions: A flow diagram of study selection is shown in Figure 1. A total of 543 potentially relevant articles were initially identified and screened, and 488 of them were subsequently excluded. Of the 55 full-text articles reviewed, 40 were excluded and ultimately 15 studies11,15–28 were included in the meta-analysis.

Bottom Line: Meta-analysis of the seven studies that reported KI data indicated no significant treatment effect of phytoestrogen as compared to placebo (pooled mean difference = 6.44, p = 0.110).Meta-analysis of the ten studies that reported hot flush data indicated that phytoestrogens result in a significantly greater reduction in hot flush frequency compared to placebo (pooled mean difference = 0.89, p < 0.005).Phytoestrogens appear to reduce the frequency of hot flushes in menopausal women, without serious side-effects.

View Article: PubMed Central - PubMed

Affiliation: Hsin Sheng Junior College of Medical Care and Management , Taoyuan.

ABSTRACT

Objective: To perform a meta-analysis examining the efficacy of phytoestrogens for the relief of menopausal symptoms.

Methods: Medline, Cochrane, EMBASE, and Google Scholar databases were searched until September 30, 2013 using the following key words: vasomotor symptoms, menopausal symptoms, phytoestrogens, isoflavones, coumestrol, soy, red clover. Inclusion criteria were (1) randomized controlled trial (RCT), (2) perimenopausal or postmenopausal women experiencing menopausal symptoms, (3) intervention with an oral phytoestrogen. Outcome measures included Kupperman index (KI) changes, daily hot flush frequency, and the likelihood of side-effects.

Results: Of 543 potentially relevant studies identified, 15 RCTs meeting the inclusion criteria were included. The mean age of the subjects ranged from 49 to 58.3 and 48 to 60.1 years, respectively, in the placebo and phytoestrogen groups. The number of participants ranged from 30 to 252, and the intervention periods ranged from 3 to 12 months. Meta-analysis of the seven studies that reported KI data indicated no significant treatment effect of phytoestrogen as compared to placebo (pooled mean difference = 6.44, p = 0.110). Meta-analysis of the ten studies that reported hot flush data indicated that phytoestrogens result in a significantly greater reduction in hot flush frequency compared to placebo (pooled mean difference = 0.89, p < 0.005). Meta-analysis of the five studies that reported side-effect data showed no significant difference between the two groups (p = 0.175).

Conclusion: Phytoestrogens appear to reduce the frequency of hot flushes in menopausal women, without serious side-effects.

Show MeSH
Related in: MedlinePlus