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Magnetization transfer imaging of suicidal patients with major depressive disorder.

Chen Z, Zhang H, Jia Z, Zhong J, Huang X, Du M, Chen L, Kuang W, Sweeney JA, Gong Q - Sci Rep (2015)

Bottom Line: We identified decreased MTR in left inferior parietal lobule and right superior parietal lobule in suicide attempters relative to both non-attempters and controls.Non-attempters also showed significantly reduced MTR in left inferior parietal lobule relative to controls, as well as an MTR reduction in left cerebellum.Parietal lobe abnormalities might cause attentional dysfunction and impaired decision making to increase risk for suicidal behavior in MDD.

View Article: PubMed Central - PubMed

Affiliation: Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, PR China.

ABSTRACT
Magnetization transfer imaging (MTI) provides a quantitative measure of the macromolecular structural integrity of brain tissue, as represented by magnetization transfer ratio (MTR). In this study, we utilized MTI to identify biophysical alterations in MDD patients with a history of suicide attempts relative to MDD patients without such history. The participants were 36 medication-free MDD patients, with (N = 17) and without (N = 19) a history of a suicide attempt, and 28 healthy controls matched for age and gender. Whole brain voxel-based analysis was used to compare MTR across three groups and to analyze correlations with symptom severity and illness duration. We identified decreased MTR in left inferior parietal lobule and right superior parietal lobule in suicide attempters relative to both non-attempters and controls. Non-attempters also showed significantly reduced MTR in left inferior parietal lobule relative to controls, as well as an MTR reduction in left cerebellum. These abnormalities were not correlated with symptom severity or illness duration. Depressed patients with a history of suicide attempt showed bilateral abnormalities in parietal cortex compared to nonsuicidal depressed patients and healthy controls. Parietal lobe abnormalities might cause attentional dysfunction and impaired decision making to increase risk for suicidal behavior in MDD.

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Related in: MedlinePlus

Regions of interest (head of bilateral caudate nucleus) for magnetization transfer ratio analysis.
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f3: Regions of interest (head of bilateral caudate nucleus) for magnetization transfer ratio analysis.

Mentions: In a secondary analysis, ITK-SNAP (www.itksnap.org)51 was used to obtain bilateral measures of the head of the caudate nucleus. This was done based on a previous MT study reporting focal biophysical abnormalities in this region in depression41. The slice displaying the most anterior margin of genu of the corpus callosum (Montreal Neurological Institute (MNI) coordinates: [1, 32, 6]) was chosen as the reference slice for placing the ROI, since this landmark could be easily and consistently identified across subjects (see Figure 3). We used constant volumes 72 mm3 for the head of caudate nucleus in the MTR maps of all subjects and the MTR values were extracted bilaterally and compared across groups using univariate analysis of covariance controlling for age and sex.


Magnetization transfer imaging of suicidal patients with major depressive disorder.

Chen Z, Zhang H, Jia Z, Zhong J, Huang X, Du M, Chen L, Kuang W, Sweeney JA, Gong Q - Sci Rep (2015)

Regions of interest (head of bilateral caudate nucleus) for magnetization transfer ratio analysis.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4389668&req=5

f3: Regions of interest (head of bilateral caudate nucleus) for magnetization transfer ratio analysis.
Mentions: In a secondary analysis, ITK-SNAP (www.itksnap.org)51 was used to obtain bilateral measures of the head of the caudate nucleus. This was done based on a previous MT study reporting focal biophysical abnormalities in this region in depression41. The slice displaying the most anterior margin of genu of the corpus callosum (Montreal Neurological Institute (MNI) coordinates: [1, 32, 6]) was chosen as the reference slice for placing the ROI, since this landmark could be easily and consistently identified across subjects (see Figure 3). We used constant volumes 72 mm3 for the head of caudate nucleus in the MTR maps of all subjects and the MTR values were extracted bilaterally and compared across groups using univariate analysis of covariance controlling for age and sex.

Bottom Line: We identified decreased MTR in left inferior parietal lobule and right superior parietal lobule in suicide attempters relative to both non-attempters and controls.Non-attempters also showed significantly reduced MTR in left inferior parietal lobule relative to controls, as well as an MTR reduction in left cerebellum.Parietal lobe abnormalities might cause attentional dysfunction and impaired decision making to increase risk for suicidal behavior in MDD.

View Article: PubMed Central - PubMed

Affiliation: Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, PR China.

ABSTRACT
Magnetization transfer imaging (MTI) provides a quantitative measure of the macromolecular structural integrity of brain tissue, as represented by magnetization transfer ratio (MTR). In this study, we utilized MTI to identify biophysical alterations in MDD patients with a history of suicide attempts relative to MDD patients without such history. The participants were 36 medication-free MDD patients, with (N = 17) and without (N = 19) a history of a suicide attempt, and 28 healthy controls matched for age and gender. Whole brain voxel-based analysis was used to compare MTR across three groups and to analyze correlations with symptom severity and illness duration. We identified decreased MTR in left inferior parietal lobule and right superior parietal lobule in suicide attempters relative to both non-attempters and controls. Non-attempters also showed significantly reduced MTR in left inferior parietal lobule relative to controls, as well as an MTR reduction in left cerebellum. These abnormalities were not correlated with symptom severity or illness duration. Depressed patients with a history of suicide attempt showed bilateral abnormalities in parietal cortex compared to nonsuicidal depressed patients and healthy controls. Parietal lobe abnormalities might cause attentional dysfunction and impaired decision making to increase risk for suicidal behavior in MDD.

Show MeSH
Related in: MedlinePlus