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Magnetization transfer imaging of suicidal patients with major depressive disorder.

Chen Z, Zhang H, Jia Z, Zhong J, Huang X, Du M, Chen L, Kuang W, Sweeney JA, Gong Q - Sci Rep (2015)

Bottom Line: We identified decreased MTR in left inferior parietal lobule and right superior parietal lobule in suicide attempters relative to both non-attempters and controls.Non-attempters also showed significantly reduced MTR in left inferior parietal lobule relative to controls, as well as an MTR reduction in left cerebellum.Parietal lobe abnormalities might cause attentional dysfunction and impaired decision making to increase risk for suicidal behavior in MDD.

View Article: PubMed Central - PubMed

Affiliation: Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, PR China.

ABSTRACT
Magnetization transfer imaging (MTI) provides a quantitative measure of the macromolecular structural integrity of brain tissue, as represented by magnetization transfer ratio (MTR). In this study, we utilized MTI to identify biophysical alterations in MDD patients with a history of suicide attempts relative to MDD patients without such history. The participants were 36 medication-free MDD patients, with (N = 17) and without (N = 19) a history of a suicide attempt, and 28 healthy controls matched for age and gender. Whole brain voxel-based analysis was used to compare MTR across three groups and to analyze correlations with symptom severity and illness duration. We identified decreased MTR in left inferior parietal lobule and right superior parietal lobule in suicide attempters relative to both non-attempters and controls. Non-attempters also showed significantly reduced MTR in left inferior parietal lobule relative to controls, as well as an MTR reduction in left cerebellum. These abnormalities were not correlated with symptom severity or illness duration. Depressed patients with a history of suicide attempt showed bilateral abnormalities in parietal cortex compared to nonsuicidal depressed patients and healthy controls. Parietal lobe abnormalities might cause attentional dysfunction and impaired decision making to increase risk for suicidal behavior in MDD.

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Magnetization transfer ratio differences in voxel-based analysis comparisons among major depressive disorder patients, with and without a history of suicide attempts, and healthy comparison subjectsa.a Images are presented in neurological convention. Suicide attempters showed reduced MTR in (A) the left inferior parietal lobule and (B) the right superior parietal lobule relative to non-attempters and healthy controls. Non-attempters showed reduced MTR in (A) the left inferior parietal lobule and (C) the left cerebellum (posterior lobe) relative to healthy controls. Statistical inferences were made with a voxel-level statistical threshold of p < 0.05 (corrected). Abbreviations: HC = healthy comparison subjects; L = left; MTR = magnetization transfer ratio; nSA = depressed patients without a history of suicide attempts; R = right; SA = depressed patients with a history of suicide attempts.
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f1: Magnetization transfer ratio differences in voxel-based analysis comparisons among major depressive disorder patients, with and without a history of suicide attempts, and healthy comparison subjectsa.a Images are presented in neurological convention. Suicide attempters showed reduced MTR in (A) the left inferior parietal lobule and (B) the right superior parietal lobule relative to non-attempters and healthy controls. Non-attempters showed reduced MTR in (A) the left inferior parietal lobule and (C) the left cerebellum (posterior lobe) relative to healthy controls. Statistical inferences were made with a voxel-level statistical threshold of p < 0.05 (corrected). Abbreviations: HC = healthy comparison subjects; L = left; MTR = magnetization transfer ratio; nSA = depressed patients without a history of suicide attempts; R = right; SA = depressed patients with a history of suicide attempts.

Mentions: The three groups had significant differences of MTR in the left inferior parietal lobule, right superior parietal lobule and left cerebellum (posterior lobe) (Figure 1, Table 2). Post-hoc t tests showed that suicide attempters had reduced MTR in the left inferior parietal lobule and right superior parietal lobule relative to both non-attempters (p = 0.005 and p < 0.001, respectively) and healthy controls (p < 0.001 and p = 0.003, respectively). Non-attempters also showed reduced MTR in the left inferior parietal lobule (p = 0.012), as well as a reduction in left cerebellum (posterior lobe) (p < 0.001) relative to healthy controls. No other significant group differences were identified. Figure 2 illustrates the changes in the MTR values in these affected regions. No association was found between regional MTR values and HAM-D scores or illness duration.


Magnetization transfer imaging of suicidal patients with major depressive disorder.

Chen Z, Zhang H, Jia Z, Zhong J, Huang X, Du M, Chen L, Kuang W, Sweeney JA, Gong Q - Sci Rep (2015)

Magnetization transfer ratio differences in voxel-based analysis comparisons among major depressive disorder patients, with and without a history of suicide attempts, and healthy comparison subjectsa.a Images are presented in neurological convention. Suicide attempters showed reduced MTR in (A) the left inferior parietal lobule and (B) the right superior parietal lobule relative to non-attempters and healthy controls. Non-attempters showed reduced MTR in (A) the left inferior parietal lobule and (C) the left cerebellum (posterior lobe) relative to healthy controls. Statistical inferences were made with a voxel-level statistical threshold of p < 0.05 (corrected). Abbreviations: HC = healthy comparison subjects; L = left; MTR = magnetization transfer ratio; nSA = depressed patients without a history of suicide attempts; R = right; SA = depressed patients with a history of suicide attempts.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4389668&req=5

f1: Magnetization transfer ratio differences in voxel-based analysis comparisons among major depressive disorder patients, with and without a history of suicide attempts, and healthy comparison subjectsa.a Images are presented in neurological convention. Suicide attempters showed reduced MTR in (A) the left inferior parietal lobule and (B) the right superior parietal lobule relative to non-attempters and healthy controls. Non-attempters showed reduced MTR in (A) the left inferior parietal lobule and (C) the left cerebellum (posterior lobe) relative to healthy controls. Statistical inferences were made with a voxel-level statistical threshold of p < 0.05 (corrected). Abbreviations: HC = healthy comparison subjects; L = left; MTR = magnetization transfer ratio; nSA = depressed patients without a history of suicide attempts; R = right; SA = depressed patients with a history of suicide attempts.
Mentions: The three groups had significant differences of MTR in the left inferior parietal lobule, right superior parietal lobule and left cerebellum (posterior lobe) (Figure 1, Table 2). Post-hoc t tests showed that suicide attempters had reduced MTR in the left inferior parietal lobule and right superior parietal lobule relative to both non-attempters (p = 0.005 and p < 0.001, respectively) and healthy controls (p < 0.001 and p = 0.003, respectively). Non-attempters also showed reduced MTR in the left inferior parietal lobule (p = 0.012), as well as a reduction in left cerebellum (posterior lobe) (p < 0.001) relative to healthy controls. No other significant group differences were identified. Figure 2 illustrates the changes in the MTR values in these affected regions. No association was found between regional MTR values and HAM-D scores or illness duration.

Bottom Line: We identified decreased MTR in left inferior parietal lobule and right superior parietal lobule in suicide attempters relative to both non-attempters and controls.Non-attempters also showed significantly reduced MTR in left inferior parietal lobule relative to controls, as well as an MTR reduction in left cerebellum.Parietal lobe abnormalities might cause attentional dysfunction and impaired decision making to increase risk for suicidal behavior in MDD.

View Article: PubMed Central - PubMed

Affiliation: Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, PR China.

ABSTRACT
Magnetization transfer imaging (MTI) provides a quantitative measure of the macromolecular structural integrity of brain tissue, as represented by magnetization transfer ratio (MTR). In this study, we utilized MTI to identify biophysical alterations in MDD patients with a history of suicide attempts relative to MDD patients without such history. The participants were 36 medication-free MDD patients, with (N = 17) and without (N = 19) a history of a suicide attempt, and 28 healthy controls matched for age and gender. Whole brain voxel-based analysis was used to compare MTR across three groups and to analyze correlations with symptom severity and illness duration. We identified decreased MTR in left inferior parietal lobule and right superior parietal lobule in suicide attempters relative to both non-attempters and controls. Non-attempters also showed significantly reduced MTR in left inferior parietal lobule relative to controls, as well as an MTR reduction in left cerebellum. These abnormalities were not correlated with symptom severity or illness duration. Depressed patients with a history of suicide attempt showed bilateral abnormalities in parietal cortex compared to nonsuicidal depressed patients and healthy controls. Parietal lobe abnormalities might cause attentional dysfunction and impaired decision making to increase risk for suicidal behavior in MDD.

Show MeSH
Related in: MedlinePlus