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Glioma grading by microvascular permeability parameters derived from dynamic contrast-enhanced MRI and intratumoral susceptibility signal on susceptibility weighted imaging.

Li X, Zhu Y, Kang H, Zhang Y, Liang H, Wang S, Zhang W - Cancer Imaging (2015)

Bottom Line: Dynamic contrast-enhanced MRI (DCE-MRI) estimates vascular permeability of brain tumors, and susceptibility-weighted imaging (SWI) may demonstrate tumor vascularity by intratumoral susceptibility signals (ITSS).Ktrans values were moderately correlated with ITSS in the same segments (P<0.01).There was a moderate correlation between Ktrans and ITSS in the same tumor segments.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, 400042, China. lixiaoguang0708@qq.com.

ABSTRACT

Background: Dynamic contrast-enhanced MRI (DCE-MRI) estimates vascular permeability of brain tumors, and susceptibility-weighted imaging (SWI) may demonstrate tumor vascularity by intratumoral susceptibility signals (ITSS). This study assessed volume transfer constant (Ktrans) accuracy, the volume of extravascular extracellular space (EES) per unit volume of tissue (Ve) derived from DCE-MRI, and the degree of ITSS in glioma grading.

Methods: Thirty-two patients with different glioma grades were enrolled in this retrospective study. Patients underwent DCE-MRI and non-contrast enhanced SWI by three-tesla scanning. Ktrans values, Ve, and the degree of ITSS in glioma were compared. Receiver operating characteristic (ROC) curve analysis determined diagnostic performances of Ktrans and Ve in glioma grading, and Spearman's correlation analysis determined the associations between Ktrans, Ve, ITSS, and tumor grade.

Results: Ktrans and Ve values were significantly different between low grade gliomas (LGGs) and both high grade gliomas (HGGs) and grade II, III and IV gliomas (P<0.01). The degree of ITSS of LGGs was lower than HGGs (P<0.01), and the ITSS of grade II gliomas was lower than grade III or IV gliomas. Ktrans and Ve were correlated with glioma grade (P<0.01), while ITSS was moderately correlated (P<0.01). Ktrans values were moderately correlated with ITSS in the same segments (P<0.01).

Conclusion: Ktrans and Ve values, and ITSS helped distinguish the differences between LGGs and HGGs and between grade II, III and IV gliomas. There was a moderate correlation between Ktrans and ITSS in the same tumor segments.

No MeSH data available.


Related in: MedlinePlus

Images(a-d) of a 44-year-old woman with right temporal anaplastic oligodendrogliomas. (a) Contrast-enhanced T1-weighted image shows a mass with irregular enhancement. (b) Ktrans map shows high Ktrans values in the tumor, including (c) a maximum degree of ITSS in the SWI. (d) Co-registered image of Ktrans and SWI shows that regions of the highest value of Ktrans(arrows) does not correspond with areas of attenuated prominent ITSS in the same segment. (e) Representative immunohistochemical staining(CD34, Original magnification,×200) shows abundant angiogenesis in the tumor, with high MVD, bizarre vascular formation and large VD.
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Fig3: Images(a-d) of a 44-year-old woman with right temporal anaplastic oligodendrogliomas. (a) Contrast-enhanced T1-weighted image shows a mass with irregular enhancement. (b) Ktrans map shows high Ktrans values in the tumor, including (c) a maximum degree of ITSS in the SWI. (d) Co-registered image of Ktrans and SWI shows that regions of the highest value of Ktrans(arrows) does not correspond with areas of attenuated prominent ITSS in the same segment. (e) Representative immunohistochemical staining(CD34, Original magnification,×200) shows abundant angiogenesis in the tumor, with high MVD, bizarre vascular formation and large VD.

Mentions: ITSS were seen in 8 of 9 grade IV patients, in all 8 grade III patients, and in 11 of 15 grade II patients. The Kruskal-Wallis test results showed that the degree of ITSS of LGGs was significantly lower than that of HGGs (P < 0.01) (Table 1), and there were significant differences in ITSS degrees between grade II and grade III or IV (P < 0.01 and P < 0.05, respectively). However, no statistical difference was found between grade III and grade IV gliomas (Table 2). Spearman’s correlation analysis showed a moderate correlation between the degree of ITSS and tumor grade (r = 0.515, P < 0.01, Table 4). Either no or sporadic dot-like ITSS were found in LGGs (Figure 1c) except for the densely prominent ITSS in the 4 cases of oligodendroglioma (Figure 2c) and single case of oligoastrocytoma. However, the agglomerated mixed nodular and fine linear ITSS were seen frequently in HGGs with the exception of one glioblastoma (Figures 3c and 4c).Table 4


Glioma grading by microvascular permeability parameters derived from dynamic contrast-enhanced MRI and intratumoral susceptibility signal on susceptibility weighted imaging.

Li X, Zhu Y, Kang H, Zhang Y, Liang H, Wang S, Zhang W - Cancer Imaging (2015)

Images(a-d) of a 44-year-old woman with right temporal anaplastic oligodendrogliomas. (a) Contrast-enhanced T1-weighted image shows a mass with irregular enhancement. (b) Ktrans map shows high Ktrans values in the tumor, including (c) a maximum degree of ITSS in the SWI. (d) Co-registered image of Ktrans and SWI shows that regions of the highest value of Ktrans(arrows) does not correspond with areas of attenuated prominent ITSS in the same segment. (e) Representative immunohistochemical staining(CD34, Original magnification,×200) shows abundant angiogenesis in the tumor, with high MVD, bizarre vascular formation and large VD.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4389664&req=5

Fig3: Images(a-d) of a 44-year-old woman with right temporal anaplastic oligodendrogliomas. (a) Contrast-enhanced T1-weighted image shows a mass with irregular enhancement. (b) Ktrans map shows high Ktrans values in the tumor, including (c) a maximum degree of ITSS in the SWI. (d) Co-registered image of Ktrans and SWI shows that regions of the highest value of Ktrans(arrows) does not correspond with areas of attenuated prominent ITSS in the same segment. (e) Representative immunohistochemical staining(CD34, Original magnification,×200) shows abundant angiogenesis in the tumor, with high MVD, bizarre vascular formation and large VD.
Mentions: ITSS were seen in 8 of 9 grade IV patients, in all 8 grade III patients, and in 11 of 15 grade II patients. The Kruskal-Wallis test results showed that the degree of ITSS of LGGs was significantly lower than that of HGGs (P < 0.01) (Table 1), and there were significant differences in ITSS degrees between grade II and grade III or IV (P < 0.01 and P < 0.05, respectively). However, no statistical difference was found between grade III and grade IV gliomas (Table 2). Spearman’s correlation analysis showed a moderate correlation between the degree of ITSS and tumor grade (r = 0.515, P < 0.01, Table 4). Either no or sporadic dot-like ITSS were found in LGGs (Figure 1c) except for the densely prominent ITSS in the 4 cases of oligodendroglioma (Figure 2c) and single case of oligoastrocytoma. However, the agglomerated mixed nodular and fine linear ITSS were seen frequently in HGGs with the exception of one glioblastoma (Figures 3c and 4c).Table 4

Bottom Line: Dynamic contrast-enhanced MRI (DCE-MRI) estimates vascular permeability of brain tumors, and susceptibility-weighted imaging (SWI) may demonstrate tumor vascularity by intratumoral susceptibility signals (ITSS).Ktrans values were moderately correlated with ITSS in the same segments (P<0.01).There was a moderate correlation between Ktrans and ITSS in the same tumor segments.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, 400042, China. lixiaoguang0708@qq.com.

ABSTRACT

Background: Dynamic contrast-enhanced MRI (DCE-MRI) estimates vascular permeability of brain tumors, and susceptibility-weighted imaging (SWI) may demonstrate tumor vascularity by intratumoral susceptibility signals (ITSS). This study assessed volume transfer constant (Ktrans) accuracy, the volume of extravascular extracellular space (EES) per unit volume of tissue (Ve) derived from DCE-MRI, and the degree of ITSS in glioma grading.

Methods: Thirty-two patients with different glioma grades were enrolled in this retrospective study. Patients underwent DCE-MRI and non-contrast enhanced SWI by three-tesla scanning. Ktrans values, Ve, and the degree of ITSS in glioma were compared. Receiver operating characteristic (ROC) curve analysis determined diagnostic performances of Ktrans and Ve in glioma grading, and Spearman's correlation analysis determined the associations between Ktrans, Ve, ITSS, and tumor grade.

Results: Ktrans and Ve values were significantly different between low grade gliomas (LGGs) and both high grade gliomas (HGGs) and grade II, III and IV gliomas (P<0.01). The degree of ITSS of LGGs was lower than HGGs (P<0.01), and the ITSS of grade II gliomas was lower than grade III or IV gliomas. Ktrans and Ve were correlated with glioma grade (P<0.01), while ITSS was moderately correlated (P<0.01). Ktrans values were moderately correlated with ITSS in the same segments (P<0.01).

Conclusion: Ktrans and Ve values, and ITSS helped distinguish the differences between LGGs and HGGs and between grade II, III and IV gliomas. There was a moderate correlation between Ktrans and ITSS in the same tumor segments.

No MeSH data available.


Related in: MedlinePlus