Omega-3 supplementation combined with anti-vascular endothelial growth factor lowers vitreal levels of vascular endothelial growth factor in wet age-related macular degeneration.
Bottom Line: Secondary outcomes were plasma VEGF-A and central foveal thickness.Patients receiving omega-3s (group 1) had significantly lower levels of vitreal VEGF-A (141.11 ± 61.89 pg/mL) when compared with group 2 (626.09 ± 279.27 pg/mL; P = .036) and group 3 (735.48 ± 216.43 pg/mL; P = .013), but similar levels to group 4 (235.81 ± 33.99 pg/mL; P = .215).This study demonstrated that omega-3 supplementation combined with anti-VEGF treatment is associated with decreased vitreal VEGF-A levels in wet AMD patients.
Affiliation: Department of Ophthalmology, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec, Canada. Electronic address: email@example.com.Show MeSH
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Mentions: The range of vitreous concentrations of VEGF-A in patients with wet AMD was much wider for groups not receiving the omega-3 LCPUFA supplementation. Group 1 (anti-VEGF injections + Vitalux plus Omega-3) had significantly lower levels of VEGF-A in the vitreous when compared with group 2 (anti-VEGF injections + Vitalux AREDS without omega-3 LCPUFAs; P = .036) and group 3 (treatment-naïve anti-VEGF injections + no planned supplement intervention; P = .014), but not when compared with group 4 (control; P = .215; Figure 2). Both wet AMD groups not taking omega-3 supplementation (groups 2 and 3) had similar levels of vitreous VEGF-A (P = .758). Group 3 (treatment naïve) had significantly higher vitreous levels of VEGF-A when compared with nonvascular ocular pathologic features group 4 (controls; P = .039; Figure 2). Seven of 9 patients in group 1 had concentrations of vitreous VEGF-A lower than all but 1 of the patients in group 2 (Figure 2).
Affiliation: Department of Ophthalmology, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec, Canada. Electronic address: firstname.lastname@example.org.