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Omega-3 supplementation combined with anti-vascular endothelial growth factor lowers vitreal levels of vascular endothelial growth factor in wet age-related macular degeneration.

Rezende FA, Lapalme E, Qian CX, Smith LE, SanGiovanni JP, Sapieha P - Am. J. Ophthalmol. (2014)

Bottom Line: Secondary outcomes were plasma VEGF-A and central foveal thickness.Patients receiving omega-3s (group 1) had significantly lower levels of vitreal VEGF-A (141.11 ± 61.89 pg/mL) when compared with group 2 (626.09 ± 279.27 pg/mL; P = .036) and group 3 (735.48 ± 216.43 pg/mL; P = .013), but similar levels to group 4 (235.81 ± 33.99 pg/mL; P = .215).This study demonstrated that omega-3 supplementation combined with anti-VEGF treatment is associated with decreased vitreal VEGF-A levels in wet AMD patients.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec, Canada. Electronic address: frezendef@hotmail.com.

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Related in: MedlinePlus

Graph showing omega-3 supplementation and vitreous vascular endothelial growth factor (VEGF) A concentrations in wet age-related macular degeneration and control patients. Concentrations of vitreous VEGF-A, demonstrating that group 1 (anti-VEGF plus omega-3; n=9) had significantly lower levels than group 2 (anti-VEGF alone; n=6; P=.0360) and group 3 (treatment naïve, starting on anti-VEGF; n = 7; P = .0139). Data also demonstrate that group 1 (anti-VEGF plus omega-3) and group 4 (control; n=8) had similar vitreous VEGF levels (P = .2153) and that group 3 (treatment naïve) had significantly higher vitreous VEGF levels than group 4 (control; P = .0387). Group 2 (anti-VEGF alone) and group 3 (treatment naïve), both not taking omega-3 supplementation, had similar vitreous VEGF levels (P = .7582, t test).
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Figure 2: Graph showing omega-3 supplementation and vitreous vascular endothelial growth factor (VEGF) A concentrations in wet age-related macular degeneration and control patients. Concentrations of vitreous VEGF-A, demonstrating that group 1 (anti-VEGF plus omega-3; n=9) had significantly lower levels than group 2 (anti-VEGF alone; n=6; P=.0360) and group 3 (treatment naïve, starting on anti-VEGF; n = 7; P = .0139). Data also demonstrate that group 1 (anti-VEGF plus omega-3) and group 4 (control; n=8) had similar vitreous VEGF levels (P = .2153) and that group 3 (treatment naïve) had significantly higher vitreous VEGF levels than group 4 (control; P = .0387). Group 2 (anti-VEGF alone) and group 3 (treatment naïve), both not taking omega-3 supplementation, had similar vitreous VEGF levels (P = .7582, t test).

Mentions: The range of vitreous concentrations of VEGF-A in patients with wet AMD was much wider for groups not receiving the omega-3 LCPUFA supplementation. Group 1 (anti-VEGF injections + Vitalux plus Omega-3) had significantly lower levels of VEGF-A in the vitreous when compared with group 2 (anti-VEGF injections + Vitalux AREDS without omega-3 LCPUFAs; P = .036) and group 3 (treatment-naïve anti-VEGF injections + no planned supplement intervention; P = .014), but not when compared with group 4 (control; P = .215; Figure 2). Both wet AMD groups not taking omega-3 supplementation (groups 2 and 3) had similar levels of vitreous VEGF-A (P = .758). Group 3 (treatment naïve) had significantly higher vitreous levels of VEGF-A when compared with nonvascular ocular pathologic features group 4 (controls; P = .039; Figure 2). Seven of 9 patients in group 1 had concentrations of vitreous VEGF-A lower than all but 1 of the patients in group 2 (Figure 2).


Omega-3 supplementation combined with anti-vascular endothelial growth factor lowers vitreal levels of vascular endothelial growth factor in wet age-related macular degeneration.

Rezende FA, Lapalme E, Qian CX, Smith LE, SanGiovanni JP, Sapieha P - Am. J. Ophthalmol. (2014)

Graph showing omega-3 supplementation and vitreous vascular endothelial growth factor (VEGF) A concentrations in wet age-related macular degeneration and control patients. Concentrations of vitreous VEGF-A, demonstrating that group 1 (anti-VEGF plus omega-3; n=9) had significantly lower levels than group 2 (anti-VEGF alone; n=6; P=.0360) and group 3 (treatment naïve, starting on anti-VEGF; n = 7; P = .0139). Data also demonstrate that group 1 (anti-VEGF plus omega-3) and group 4 (control; n=8) had similar vitreous VEGF levels (P = .2153) and that group 3 (treatment naïve) had significantly higher vitreous VEGF levels than group 4 (control; P = .0387). Group 2 (anti-VEGF alone) and group 3 (treatment naïve), both not taking omega-3 supplementation, had similar vitreous VEGF levels (P = .7582, t test).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4389631&req=5

Figure 2: Graph showing omega-3 supplementation and vitreous vascular endothelial growth factor (VEGF) A concentrations in wet age-related macular degeneration and control patients. Concentrations of vitreous VEGF-A, demonstrating that group 1 (anti-VEGF plus omega-3; n=9) had significantly lower levels than group 2 (anti-VEGF alone; n=6; P=.0360) and group 3 (treatment naïve, starting on anti-VEGF; n = 7; P = .0139). Data also demonstrate that group 1 (anti-VEGF plus omega-3) and group 4 (control; n=8) had similar vitreous VEGF levels (P = .2153) and that group 3 (treatment naïve) had significantly higher vitreous VEGF levels than group 4 (control; P = .0387). Group 2 (anti-VEGF alone) and group 3 (treatment naïve), both not taking omega-3 supplementation, had similar vitreous VEGF levels (P = .7582, t test).
Mentions: The range of vitreous concentrations of VEGF-A in patients with wet AMD was much wider for groups not receiving the omega-3 LCPUFA supplementation. Group 1 (anti-VEGF injections + Vitalux plus Omega-3) had significantly lower levels of VEGF-A in the vitreous when compared with group 2 (anti-VEGF injections + Vitalux AREDS without omega-3 LCPUFAs; P = .036) and group 3 (treatment-naïve anti-VEGF injections + no planned supplement intervention; P = .014), but not when compared with group 4 (control; P = .215; Figure 2). Both wet AMD groups not taking omega-3 supplementation (groups 2 and 3) had similar levels of vitreous VEGF-A (P = .758). Group 3 (treatment naïve) had significantly higher vitreous levels of VEGF-A when compared with nonvascular ocular pathologic features group 4 (controls; P = .039; Figure 2). Seven of 9 patients in group 1 had concentrations of vitreous VEGF-A lower than all but 1 of the patients in group 2 (Figure 2).

Bottom Line: Secondary outcomes were plasma VEGF-A and central foveal thickness.Patients receiving omega-3s (group 1) had significantly lower levels of vitreal VEGF-A (141.11 ± 61.89 pg/mL) when compared with group 2 (626.09 ± 279.27 pg/mL; P = .036) and group 3 (735.48 ± 216.43 pg/mL; P = .013), but similar levels to group 4 (235.81 ± 33.99 pg/mL; P = .215).This study demonstrated that omega-3 supplementation combined with anti-VEGF treatment is associated with decreased vitreal VEGF-A levels in wet AMD patients.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec, Canada. Electronic address: frezendef@hotmail.com.

Show MeSH
Related in: MedlinePlus