Limits...
CD44 Acts as a Signaling Platform Controlling Tumor Progression and Metastasis.

Orian-Rousseau V - Front Immunol (2015)

Bottom Line: Members of the CD44 family of transmembrane glycoproteins emerge as major signal transduction control units.CD44 isoforms participate in several signaling pathways ranging from growth factor-induced signaling to Wnt-regulated pathways.It is foreseeable that a link between the expression of CD44 isoforms in CSCs and their function as signaling regulators will be drawn in a near future.

View Article: PubMed Central - PubMed

Affiliation: Institute of Toxicology and Genetics, Karlsruhe Institute of Technology , Karlsruhe , Germany.

ABSTRACT
Members of the CD44 family of transmembrane glycoproteins emerge as major signal transduction control units. CD44 isoforms participate in several signaling pathways ranging from growth factor-induced signaling to Wnt-regulated pathways. The role of the CD44 family members in tumor progression and metastasis is most likely linked to the function of the various isoforms as signaling hubs. Increasing evidence suggests that these proteins are not solely cancer stem cell (CSC) markers but are directly involved in tumor and metastasis initiation. It is foreseeable that a link between the expression of CD44 isoforms in CSCs and their function as signaling regulators will be drawn in a near future.

No MeSH data available.


Related in: MedlinePlus

CD44 acts as a co-receptor for several cell surface receptors including RTKs, G-protein coupled receptors, and LRP6. Hyaluronan binding to CD44 increases CXCL12-induced CXCR4-G Protein signaling (18). RTKs activation by their ligands [growth factors (GFs) such as HGF or VEGF] and downstream signaling are dependent on CD44v6 [reviewed in Ref. (11)]. In the Wnt-β-catenin pathway, LRP6 recruitment of CD44 leads to β-catenin activation and translocation to the nucleus (3).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4389564&req=5

Figure 1: CD44 acts as a co-receptor for several cell surface receptors including RTKs, G-protein coupled receptors, and LRP6. Hyaluronan binding to CD44 increases CXCL12-induced CXCR4-G Protein signaling (18). RTKs activation by their ligands [growth factors (GFs) such as HGF or VEGF] and downstream signaling are dependent on CD44v6 [reviewed in Ref. (11)]. In the Wnt-β-catenin pathway, LRP6 recruitment of CD44 leads to β-catenin activation and translocation to the nucleus (3).

Mentions: CD44s is expressed in nearly all tissues whereas the expression of CD44v isoforms is restricted to specific cell types [reviewed in Ref. (1) and table in Ref. (3)]. In human skin, the longest CD44 isoform containing the variants v2–v10 can be detected. Expression of CD44 variants on normal lymphohematopoietic cells is generally low. T lymphocytes activation by antigen or by mitogen leads, however, to transient expression of variant isoforms such as CD44v6 (4, 5). CD44v6 isoforms are also found in proliferative tissues such as the skin or the intestine (Figure 1).


CD44 Acts as a Signaling Platform Controlling Tumor Progression and Metastasis.

Orian-Rousseau V - Front Immunol (2015)

CD44 acts as a co-receptor for several cell surface receptors including RTKs, G-protein coupled receptors, and LRP6. Hyaluronan binding to CD44 increases CXCL12-induced CXCR4-G Protein signaling (18). RTKs activation by their ligands [growth factors (GFs) such as HGF or VEGF] and downstream signaling are dependent on CD44v6 [reviewed in Ref. (11)]. In the Wnt-β-catenin pathway, LRP6 recruitment of CD44 leads to β-catenin activation and translocation to the nucleus (3).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4389564&req=5

Figure 1: CD44 acts as a co-receptor for several cell surface receptors including RTKs, G-protein coupled receptors, and LRP6. Hyaluronan binding to CD44 increases CXCL12-induced CXCR4-G Protein signaling (18). RTKs activation by their ligands [growth factors (GFs) such as HGF or VEGF] and downstream signaling are dependent on CD44v6 [reviewed in Ref. (11)]. In the Wnt-β-catenin pathway, LRP6 recruitment of CD44 leads to β-catenin activation and translocation to the nucleus (3).
Mentions: CD44s is expressed in nearly all tissues whereas the expression of CD44v isoforms is restricted to specific cell types [reviewed in Ref. (1) and table in Ref. (3)]. In human skin, the longest CD44 isoform containing the variants v2–v10 can be detected. Expression of CD44 variants on normal lymphohematopoietic cells is generally low. T lymphocytes activation by antigen or by mitogen leads, however, to transient expression of variant isoforms such as CD44v6 (4, 5). CD44v6 isoforms are also found in proliferative tissues such as the skin or the intestine (Figure 1).

Bottom Line: Members of the CD44 family of transmembrane glycoproteins emerge as major signal transduction control units.CD44 isoforms participate in several signaling pathways ranging from growth factor-induced signaling to Wnt-regulated pathways.It is foreseeable that a link between the expression of CD44 isoforms in CSCs and their function as signaling regulators will be drawn in a near future.

View Article: PubMed Central - PubMed

Affiliation: Institute of Toxicology and Genetics, Karlsruhe Institute of Technology , Karlsruhe , Germany.

ABSTRACT
Members of the CD44 family of transmembrane glycoproteins emerge as major signal transduction control units. CD44 isoforms participate in several signaling pathways ranging from growth factor-induced signaling to Wnt-regulated pathways. The role of the CD44 family members in tumor progression and metastasis is most likely linked to the function of the various isoforms as signaling hubs. Increasing evidence suggests that these proteins are not solely cancer stem cell (CSC) markers but are directly involved in tumor and metastasis initiation. It is foreseeable that a link between the expression of CD44 isoforms in CSCs and their function as signaling regulators will be drawn in a near future.

No MeSH data available.


Related in: MedlinePlus