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Age-specific MRI brain and head templates for healthy adults from 20 through 89 years of age.

Fillmore PT, Phillips-Meek MC, Richards JE - Front Aging Neurosci (2015)

Bottom Line: The participants included healthy adults from 20 through 89 years of age.It was found that age-appropriate templates provided less biased tissue classification estimates than age-inappropriate reference data and reference data based on young adult templates.This database is available for use by other investigators and clinicians for their MRI studies, as well as other types of neuroimaging and electrophysiological research.

View Article: PubMed Central - PubMed

Affiliation: Department of Communication Sciences and Disorders, University of South Carolina Columbia, SC, USA.

ABSTRACT
This study created and tested a database of adult, age-specific MRI brain and head templates. The participants included healthy adults from 20 through 89 years of age. The templates were done in five-year, 10-year, and multi-year intervals from 20 through 89 years, and consist of average T1W for the head and brain, and segmenting priors for gray matter (GM), white matter (WM), and cerebrospinal fluid (CSF). It was found that age-appropriate templates provided less biased tissue classification estimates than age-inappropriate reference data and reference data based on young adult templates. This database is available for use by other investigators and clinicians for their MRI studies, as well as other types of neuroimaging and electrophysiological research.

No MeSH data available.


Whole brain tissue and volume measures across age. (A) Gray matter (GM), white matter (WM), and other matter (OM) volumes (in mm3) over five-year age group (all participants) using the PVE based on age-appropriate five-year template priors. (B) GM + WM and inner skull volume (in mm3) over five-year age group (all participants). Inner skull volume was taken from results of the betsurf program. Ticks on each bar represent +/− one standard error.
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Figure 8: Whole brain tissue and volume measures across age. (A) Gray matter (GM), white matter (WM), and other matter (OM) volumes (in mm3) over five-year age group (all participants) using the PVE based on age-appropriate five-year template priors. (B) GM + WM and inner skull volume (in mm3) over five-year age group (all participants). Inner skull volume was taken from results of the betsurf program. Ticks on each bar represent +/− one standard error.

Mentions: To assess the ability of age-appropriate templates to confirm previously discussed characteristics of brain aging, we calculated GM, WM, and OM volumes (in mm3) for all participants using the PVE volumes based on age-appropriate five-year template priors. The results closely match previous volumetric studies in that GM volume shows a linear decrease throughout the adult lifespan, whereas WM volume stays somewhat stable, even increasingly slightly up until age 50, and then starts to decline (Figure 8). OM volume shows a small, associated increase in volume, especially after age 50 (Figure 8). We also calculated GM + WM volume and as a point of comparison, we calculated inner skull volume (also in mm3) using results of the betsurf program (described in section 2.7). Results demonstrate that at younger ages, the volume of GM + WM closely approximates that of the inner skull volume but over age a separation occurs such GM + WM volume is not as large as inner skull volume (Figure 8). This separation is likely due to the loss in GM and WM volume accompanied by an increase in OM volume.


Age-specific MRI brain and head templates for healthy adults from 20 through 89 years of age.

Fillmore PT, Phillips-Meek MC, Richards JE - Front Aging Neurosci (2015)

Whole brain tissue and volume measures across age. (A) Gray matter (GM), white matter (WM), and other matter (OM) volumes (in mm3) over five-year age group (all participants) using the PVE based on age-appropriate five-year template priors. (B) GM + WM and inner skull volume (in mm3) over five-year age group (all participants). Inner skull volume was taken from results of the betsurf program. Ticks on each bar represent +/− one standard error.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4389545&req=5

Figure 8: Whole brain tissue and volume measures across age. (A) Gray matter (GM), white matter (WM), and other matter (OM) volumes (in mm3) over five-year age group (all participants) using the PVE based on age-appropriate five-year template priors. (B) GM + WM and inner skull volume (in mm3) over five-year age group (all participants). Inner skull volume was taken from results of the betsurf program. Ticks on each bar represent +/− one standard error.
Mentions: To assess the ability of age-appropriate templates to confirm previously discussed characteristics of brain aging, we calculated GM, WM, and OM volumes (in mm3) for all participants using the PVE volumes based on age-appropriate five-year template priors. The results closely match previous volumetric studies in that GM volume shows a linear decrease throughout the adult lifespan, whereas WM volume stays somewhat stable, even increasingly slightly up until age 50, and then starts to decline (Figure 8). OM volume shows a small, associated increase in volume, especially after age 50 (Figure 8). We also calculated GM + WM volume and as a point of comparison, we calculated inner skull volume (also in mm3) using results of the betsurf program (described in section 2.7). Results demonstrate that at younger ages, the volume of GM + WM closely approximates that of the inner skull volume but over age a separation occurs such GM + WM volume is not as large as inner skull volume (Figure 8). This separation is likely due to the loss in GM and WM volume accompanied by an increase in OM volume.

Bottom Line: The participants included healthy adults from 20 through 89 years of age.It was found that age-appropriate templates provided less biased tissue classification estimates than age-inappropriate reference data and reference data based on young adult templates.This database is available for use by other investigators and clinicians for their MRI studies, as well as other types of neuroimaging and electrophysiological research.

View Article: PubMed Central - PubMed

Affiliation: Department of Communication Sciences and Disorders, University of South Carolina Columbia, SC, USA.

ABSTRACT
This study created and tested a database of adult, age-specific MRI brain and head templates. The participants included healthy adults from 20 through 89 years of age. The templates were done in five-year, 10-year, and multi-year intervals from 20 through 89 years, and consist of average T1W for the head and brain, and segmenting priors for gray matter (GM), white matter (WM), and cerebrospinal fluid (CSF). It was found that age-appropriate templates provided less biased tissue classification estimates than age-inappropriate reference data and reference data based on young adult templates. This database is available for use by other investigators and clinicians for their MRI studies, as well as other types of neuroimaging and electrophysiological research.

No MeSH data available.