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Age-specific MRI brain and head templates for healthy adults from 20 through 89 years of age.

Fillmore PT, Phillips-Meek MC, Richards JE - Front Aging Neurosci (2015)

Bottom Line: The participants included healthy adults from 20 through 89 years of age.It was found that age-appropriate templates provided less biased tissue classification estimates than age-inappropriate reference data and reference data based on young adult templates.This database is available for use by other investigators and clinicians for their MRI studies, as well as other types of neuroimaging and electrophysiological research.

View Article: PubMed Central - PubMed

Affiliation: Department of Communication Sciences and Disorders, University of South Carolina Columbia, SC, USA.

ABSTRACT
This study created and tested a database of adult, age-specific MRI brain and head templates. The participants included healthy adults from 20 through 89 years of age. The templates were done in five-year, 10-year, and multi-year intervals from 20 through 89 years, and consist of average T1W for the head and brain, and segmenting priors for gray matter (GM), white matter (WM), and cerebrospinal fluid (CSF). It was found that age-appropriate templates provided less biased tissue classification estimates than age-inappropriate reference data and reference data based on young adult templates. This database is available for use by other investigators and clinicians for their MRI studies, as well as other types of neuroimaging and electrophysiological research.

No MeSH data available.


Age-specific templates showing axial slice at AC-PC commissure (A) of brain extracted average template and mid-sagittal slice (B) of whole head average template. T1W MRI volumes across ages of study.
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Figure 3: Age-specific templates showing axial slice at AC-PC commissure (A) of brain extracted average template and mid-sagittal slice (B) of whole head average template. T1W MRI volumes across ages of study.

Mentions: Axial (A) and mid-sagittal (B) slice for each five-year age-specific T1W brain (A) and head (B) template are pictured in Figure 3. The sagittal view of the averaged templates exhibits small morphological structures in fine detail, as can be seen with cortical and subcortical anatomy. Gradual brain atrophy is noticeable especially when comparing the templates across age. All templates appear to be relatively consistent in regards to level of detail and clarity.


Age-specific MRI brain and head templates for healthy adults from 20 through 89 years of age.

Fillmore PT, Phillips-Meek MC, Richards JE - Front Aging Neurosci (2015)

Age-specific templates showing axial slice at AC-PC commissure (A) of brain extracted average template and mid-sagittal slice (B) of whole head average template. T1W MRI volumes across ages of study.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4389545&req=5

Figure 3: Age-specific templates showing axial slice at AC-PC commissure (A) of brain extracted average template and mid-sagittal slice (B) of whole head average template. T1W MRI volumes across ages of study.
Mentions: Axial (A) and mid-sagittal (B) slice for each five-year age-specific T1W brain (A) and head (B) template are pictured in Figure 3. The sagittal view of the averaged templates exhibits small morphological structures in fine detail, as can be seen with cortical and subcortical anatomy. Gradual brain atrophy is noticeable especially when comparing the templates across age. All templates appear to be relatively consistent in regards to level of detail and clarity.

Bottom Line: The participants included healthy adults from 20 through 89 years of age.It was found that age-appropriate templates provided less biased tissue classification estimates than age-inappropriate reference data and reference data based on young adult templates.This database is available for use by other investigators and clinicians for their MRI studies, as well as other types of neuroimaging and electrophysiological research.

View Article: PubMed Central - PubMed

Affiliation: Department of Communication Sciences and Disorders, University of South Carolina Columbia, SC, USA.

ABSTRACT
This study created and tested a database of adult, age-specific MRI brain and head templates. The participants included healthy adults from 20 through 89 years of age. The templates were done in five-year, 10-year, and multi-year intervals from 20 through 89 years, and consist of average T1W for the head and brain, and segmenting priors for gray matter (GM), white matter (WM), and cerebrospinal fluid (CSF). It was found that age-appropriate templates provided less biased tissue classification estimates than age-inappropriate reference data and reference data based on young adult templates. This database is available for use by other investigators and clinicians for their MRI studies, as well as other types of neuroimaging and electrophysiological research.

No MeSH data available.