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Diffusion tensor imaging of the human cerebellar pathways and their interplay with cerebral macrostructure.

Keser Z, Hasan KM, Mwangi BI, Kamali A, Ucisik-Keser FE, Riascos RF, Yozbatiran N, Francisco GE, Narayana PA - Front Neuroanat (2015)

Bottom Line: All cerebellar tract volumes were quantified and correlated with volumes of cerebral cortical, subcortical gray matter (GM), cerebral WM and cerebellar GM, and cerebellar WM.On our healthy cohort, the ratio of total cerebellar GM-to-WM was ~3.29 ± 0.24, whereas the ratio of cerebral GM-to-WM was approximately 1.10 ± 0.11.The sum of all cerebellar tract volumes is ~25.8 ± 7.3 mL, or a percentage of 1.6 ± 0.45 of the total intracranial volume (ICV).

View Article: PubMed Central - PubMed

Affiliation: Department of Physical Medicine and Rehabilitation and TIRR Memorial Hermann Neuro-Recovery Research Center, University of Texas Health Science Center Houston Houston, TX, USA.

ABSTRACT
Cerebellar white matter (WM) connections to the central nervous system are classified functionally into the Spinocerebellar (SC), vestibulocerebellar (VC), and cerebrocerebellar subdivisions. The SC pathways project from spinal cord to cerebellum, whereas the VC pathways project from vestibular organs of the inner ear. Cerebrocerebellar connections are composed of feed forward and feedback connections between cerebrum and cerebellum including the cortico-ponto-cerebellar (CPC) pathways being of cortical origin and the dentate-rubro-thalamo-cortical (DRTC) pathway being of cerebellar origin. In this study we systematically quantified the whole cerebellar system connections using diffusion tensor magnetic resonance imaging (DT-MRI). Ten right-handed healthy subjects (7 males and 3 females, age range 20-51 years) were studied. DT-MRI data were acquired with a voxel size = 2 mm × 2 mm × 2 mm at a 3.0 Tesla clinical MRI scanner. The DT-MRI data were prepared and analyzed using anatomically-guided deterministic tractography methods to reconstruct the SC, DRTC, fronto-ponto-cerebellar (FPC), parieto-ponto-cerebellar (PPC), temporo-ponto-cerebellar (TPC) and occipito-ponto-cerebellar (OPC). The DTI-attributes or the cerebellar tracts along with their cortical representation (Brodmann areas) were presented in standard Montréal Neurological Institute space. All cerebellar tract volumes were quantified and correlated with volumes of cerebral cortical, subcortical gray matter (GM), cerebral WM and cerebellar GM, and cerebellar WM. On our healthy cohort, the ratio of total cerebellar GM-to-WM was ~3.29 ± 0.24, whereas the ratio of cerebral GM-to-WM was approximately 1.10 ± 0.11. The sum of all cerebellar tract volumes is ~25.8 ± 7.3 mL, or a percentage of 1.6 ± 0.45 of the total intracranial volume (ICV).

No MeSH data available.


Summary of the mean and standard deviations of the cerebellar (A) tract volumes and corresponding (B) fractional anisotropy (FA), (C) radial diffusivity (RD), (D) axial diffusivity (AD) and (E) mean diffusivity (values of the bilateral SC, Dentate-Rubro-Thalamo-Cortical (DRTC), Fronto-Ponto-Cerebellar (FPC), Parieto-Ponto-Cerebellar (PPC), Temporo-Ponto-Cerebellar (TPC) and Occipito-Ponto-Cerebellar (OPC) fiber tracts on the ten subjects are provided. Note that MD = (AD + 2*RD) and FA is approximately a functional of AD-to-RD ratio (i.e., FA ~ AD/RD).
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Figure 7: Summary of the mean and standard deviations of the cerebellar (A) tract volumes and corresponding (B) fractional anisotropy (FA), (C) radial diffusivity (RD), (D) axial diffusivity (AD) and (E) mean diffusivity (values of the bilateral SC, Dentate-Rubro-Thalamo-Cortical (DRTC), Fronto-Ponto-Cerebellar (FPC), Parieto-Ponto-Cerebellar (PPC), Temporo-Ponto-Cerebellar (TPC) and Occipito-Ponto-Cerebellar (OPC) fiber tracts on the ten subjects are provided. Note that MD = (AD + 2*RD) and FA is approximately a functional of AD-to-RD ratio (i.e., FA ~ AD/RD).

Mentions: Table 2 and Figure 7 provide a summary of the mean and standard deviations of the tract volumes and corresponding DTI-derived values of the bilateral SC, DRTC, FPC, PPC, TPC and OPC on the ten healthy subjects. Note that mean and axial diffusivities of Left TPC and OPC are significantly greater than right ones (p < 0.05). Also Left OPC has been found to have significantly larger volume than right OPC (p < 0.05) and axial diffusivity of right DRTC has been significantly higher than the left hemispheric side.


Diffusion tensor imaging of the human cerebellar pathways and their interplay with cerebral macrostructure.

Keser Z, Hasan KM, Mwangi BI, Kamali A, Ucisik-Keser FE, Riascos RF, Yozbatiran N, Francisco GE, Narayana PA - Front Neuroanat (2015)

Summary of the mean and standard deviations of the cerebellar (A) tract volumes and corresponding (B) fractional anisotropy (FA), (C) radial diffusivity (RD), (D) axial diffusivity (AD) and (E) mean diffusivity (values of the bilateral SC, Dentate-Rubro-Thalamo-Cortical (DRTC), Fronto-Ponto-Cerebellar (FPC), Parieto-Ponto-Cerebellar (PPC), Temporo-Ponto-Cerebellar (TPC) and Occipito-Ponto-Cerebellar (OPC) fiber tracts on the ten subjects are provided. Note that MD = (AD + 2*RD) and FA is approximately a functional of AD-to-RD ratio (i.e., FA ~ AD/RD).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4389543&req=5

Figure 7: Summary of the mean and standard deviations of the cerebellar (A) tract volumes and corresponding (B) fractional anisotropy (FA), (C) radial diffusivity (RD), (D) axial diffusivity (AD) and (E) mean diffusivity (values of the bilateral SC, Dentate-Rubro-Thalamo-Cortical (DRTC), Fronto-Ponto-Cerebellar (FPC), Parieto-Ponto-Cerebellar (PPC), Temporo-Ponto-Cerebellar (TPC) and Occipito-Ponto-Cerebellar (OPC) fiber tracts on the ten subjects are provided. Note that MD = (AD + 2*RD) and FA is approximately a functional of AD-to-RD ratio (i.e., FA ~ AD/RD).
Mentions: Table 2 and Figure 7 provide a summary of the mean and standard deviations of the tract volumes and corresponding DTI-derived values of the bilateral SC, DRTC, FPC, PPC, TPC and OPC on the ten healthy subjects. Note that mean and axial diffusivities of Left TPC and OPC are significantly greater than right ones (p < 0.05). Also Left OPC has been found to have significantly larger volume than right OPC (p < 0.05) and axial diffusivity of right DRTC has been significantly higher than the left hemispheric side.

Bottom Line: All cerebellar tract volumes were quantified and correlated with volumes of cerebral cortical, subcortical gray matter (GM), cerebral WM and cerebellar GM, and cerebellar WM.On our healthy cohort, the ratio of total cerebellar GM-to-WM was ~3.29 ± 0.24, whereas the ratio of cerebral GM-to-WM was approximately 1.10 ± 0.11.The sum of all cerebellar tract volumes is ~25.8 ± 7.3 mL, or a percentage of 1.6 ± 0.45 of the total intracranial volume (ICV).

View Article: PubMed Central - PubMed

Affiliation: Department of Physical Medicine and Rehabilitation and TIRR Memorial Hermann Neuro-Recovery Research Center, University of Texas Health Science Center Houston Houston, TX, USA.

ABSTRACT
Cerebellar white matter (WM) connections to the central nervous system are classified functionally into the Spinocerebellar (SC), vestibulocerebellar (VC), and cerebrocerebellar subdivisions. The SC pathways project from spinal cord to cerebellum, whereas the VC pathways project from vestibular organs of the inner ear. Cerebrocerebellar connections are composed of feed forward and feedback connections between cerebrum and cerebellum including the cortico-ponto-cerebellar (CPC) pathways being of cortical origin and the dentate-rubro-thalamo-cortical (DRTC) pathway being of cerebellar origin. In this study we systematically quantified the whole cerebellar system connections using diffusion tensor magnetic resonance imaging (DT-MRI). Ten right-handed healthy subjects (7 males and 3 females, age range 20-51 years) were studied. DT-MRI data were acquired with a voxel size = 2 mm × 2 mm × 2 mm at a 3.0 Tesla clinical MRI scanner. The DT-MRI data were prepared and analyzed using anatomically-guided deterministic tractography methods to reconstruct the SC, DRTC, fronto-ponto-cerebellar (FPC), parieto-ponto-cerebellar (PPC), temporo-ponto-cerebellar (TPC) and occipito-ponto-cerebellar (OPC). The DTI-attributes or the cerebellar tracts along with their cortical representation (Brodmann areas) were presented in standard Montréal Neurological Institute space. All cerebellar tract volumes were quantified and correlated with volumes of cerebral cortical, subcortical gray matter (GM), cerebral WM and cerebellar GM, and cerebellar WM. On our healthy cohort, the ratio of total cerebellar GM-to-WM was ~3.29 ± 0.24, whereas the ratio of cerebral GM-to-WM was approximately 1.10 ± 0.11. The sum of all cerebellar tract volumes is ~25.8 ± 7.3 mL, or a percentage of 1.6 ± 0.45 of the total intracranial volume (ICV).

No MeSH data available.