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Diffusion tensor imaging of the human cerebellar pathways and their interplay with cerebral macrostructure.

Keser Z, Hasan KM, Mwangi BI, Kamali A, Ucisik-Keser FE, Riascos RF, Yozbatiran N, Francisco GE, Narayana PA - Front Neuroanat (2015)

Bottom Line: All cerebellar tract volumes were quantified and correlated with volumes of cerebral cortical, subcortical gray matter (GM), cerebral WM and cerebellar GM, and cerebellar WM.On our healthy cohort, the ratio of total cerebellar GM-to-WM was ~3.29 ± 0.24, whereas the ratio of cerebral GM-to-WM was approximately 1.10 ± 0.11.The sum of all cerebellar tract volumes is ~25.8 ± 7.3 mL, or a percentage of 1.6 ± 0.45 of the total intracranial volume (ICV).

View Article: PubMed Central - PubMed

Affiliation: Department of Physical Medicine and Rehabilitation and TIRR Memorial Hermann Neuro-Recovery Research Center, University of Texas Health Science Center Houston Houston, TX, USA.

ABSTRACT
Cerebellar white matter (WM) connections to the central nervous system are classified functionally into the Spinocerebellar (SC), vestibulocerebellar (VC), and cerebrocerebellar subdivisions. The SC pathways project from spinal cord to cerebellum, whereas the VC pathways project from vestibular organs of the inner ear. Cerebrocerebellar connections are composed of feed forward and feedback connections between cerebrum and cerebellum including the cortico-ponto-cerebellar (CPC) pathways being of cortical origin and the dentate-rubro-thalamo-cortical (DRTC) pathway being of cerebellar origin. In this study we systematically quantified the whole cerebellar system connections using diffusion tensor magnetic resonance imaging (DT-MRI). Ten right-handed healthy subjects (7 males and 3 females, age range 20-51 years) were studied. DT-MRI data were acquired with a voxel size = 2 mm × 2 mm × 2 mm at a 3.0 Tesla clinical MRI scanner. The DT-MRI data were prepared and analyzed using anatomically-guided deterministic tractography methods to reconstruct the SC, DRTC, fronto-ponto-cerebellar (FPC), parieto-ponto-cerebellar (PPC), temporo-ponto-cerebellar (TPC) and occipito-ponto-cerebellar (OPC). The DTI-attributes or the cerebellar tracts along with their cortical representation (Brodmann areas) were presented in standard Montréal Neurological Institute space. All cerebellar tract volumes were quantified and correlated with volumes of cerebral cortical, subcortical gray matter (GM), cerebral WM and cerebellar GM, and cerebellar WM. On our healthy cohort, the ratio of total cerebellar GM-to-WM was ~3.29 ± 0.24, whereas the ratio of cerebral GM-to-WM was approximately 1.10 ± 0.11. The sum of all cerebellar tract volumes is ~25.8 ± 7.3 mL, or a percentage of 1.6 ± 0.45 of the total intracranial volume (ICV).

No MeSH data available.


Related in: MedlinePlus

Regions-of-interest (ROI) is seeded in (A) ICP and (B) Cerebellar Hemisphere for Spinocerebellar (SC) Tract and in (C) Dentate and (D) Red Nuclei for DRTC. Coronal section of middle cerebellar peduncle being the first ROI for (E) Cortico-Ponto-Cerebellar pathways, (F) axial section of frontal lobe for fronto-ponto-cerebellar (FPC), (G) axial section of parietal lobe for parieto-ponto-cerebellar (PPC), (H) coronal section of temporal lobe for temporo-ponto-cerebellar (TPC) and (I) coronal section of occipital lobe for occipito-ponto-cerebellar (OPC) pathways are chosen as second ROI. DTI color coded (a, b and e–j and b0 (c and d) maps are used for ROI determination.
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Figure 3: Regions-of-interest (ROI) is seeded in (A) ICP and (B) Cerebellar Hemisphere for Spinocerebellar (SC) Tract and in (C) Dentate and (D) Red Nuclei for DRTC. Coronal section of middle cerebellar peduncle being the first ROI for (E) Cortico-Ponto-Cerebellar pathways, (F) axial section of frontal lobe for fronto-ponto-cerebellar (FPC), (G) axial section of parietal lobe for parieto-ponto-cerebellar (PPC), (H) coronal section of temporal lobe for temporo-ponto-cerebellar (TPC) and (I) coronal section of occipital lobe for occipito-ponto-cerebellar (OPC) pathways are chosen as second ROI. DTI color coded (a, b and e–j and b0 (c and d) maps are used for ROI determination.

Mentions: For SC (see Figures 2, 4A, 5A, 6A), first the ROI is seeded in ICP that can be seen on the axial slice of color-coded map (RGB Map) which is located at upper medulla level of the brain (see Figures 2I, 3A) and second ROI is seeded at ipsilateral cerebellar hemisphere at the same axial slice (see Figure 3B).


Diffusion tensor imaging of the human cerebellar pathways and their interplay with cerebral macrostructure.

Keser Z, Hasan KM, Mwangi BI, Kamali A, Ucisik-Keser FE, Riascos RF, Yozbatiran N, Francisco GE, Narayana PA - Front Neuroanat (2015)

Regions-of-interest (ROI) is seeded in (A) ICP and (B) Cerebellar Hemisphere for Spinocerebellar (SC) Tract and in (C) Dentate and (D) Red Nuclei for DRTC. Coronal section of middle cerebellar peduncle being the first ROI for (E) Cortico-Ponto-Cerebellar pathways, (F) axial section of frontal lobe for fronto-ponto-cerebellar (FPC), (G) axial section of parietal lobe for parieto-ponto-cerebellar (PPC), (H) coronal section of temporal lobe for temporo-ponto-cerebellar (TPC) and (I) coronal section of occipital lobe for occipito-ponto-cerebellar (OPC) pathways are chosen as second ROI. DTI color coded (a, b and e–j and b0 (c and d) maps are used for ROI determination.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4389543&req=5

Figure 3: Regions-of-interest (ROI) is seeded in (A) ICP and (B) Cerebellar Hemisphere for Spinocerebellar (SC) Tract and in (C) Dentate and (D) Red Nuclei for DRTC. Coronal section of middle cerebellar peduncle being the first ROI for (E) Cortico-Ponto-Cerebellar pathways, (F) axial section of frontal lobe for fronto-ponto-cerebellar (FPC), (G) axial section of parietal lobe for parieto-ponto-cerebellar (PPC), (H) coronal section of temporal lobe for temporo-ponto-cerebellar (TPC) and (I) coronal section of occipital lobe for occipito-ponto-cerebellar (OPC) pathways are chosen as second ROI. DTI color coded (a, b and e–j and b0 (c and d) maps are used for ROI determination.
Mentions: For SC (see Figures 2, 4A, 5A, 6A), first the ROI is seeded in ICP that can be seen on the axial slice of color-coded map (RGB Map) which is located at upper medulla level of the brain (see Figures 2I, 3A) and second ROI is seeded at ipsilateral cerebellar hemisphere at the same axial slice (see Figure 3B).

Bottom Line: All cerebellar tract volumes were quantified and correlated with volumes of cerebral cortical, subcortical gray matter (GM), cerebral WM and cerebellar GM, and cerebellar WM.On our healthy cohort, the ratio of total cerebellar GM-to-WM was ~3.29 ± 0.24, whereas the ratio of cerebral GM-to-WM was approximately 1.10 ± 0.11.The sum of all cerebellar tract volumes is ~25.8 ± 7.3 mL, or a percentage of 1.6 ± 0.45 of the total intracranial volume (ICV).

View Article: PubMed Central - PubMed

Affiliation: Department of Physical Medicine and Rehabilitation and TIRR Memorial Hermann Neuro-Recovery Research Center, University of Texas Health Science Center Houston Houston, TX, USA.

ABSTRACT
Cerebellar white matter (WM) connections to the central nervous system are classified functionally into the Spinocerebellar (SC), vestibulocerebellar (VC), and cerebrocerebellar subdivisions. The SC pathways project from spinal cord to cerebellum, whereas the VC pathways project from vestibular organs of the inner ear. Cerebrocerebellar connections are composed of feed forward and feedback connections between cerebrum and cerebellum including the cortico-ponto-cerebellar (CPC) pathways being of cortical origin and the dentate-rubro-thalamo-cortical (DRTC) pathway being of cerebellar origin. In this study we systematically quantified the whole cerebellar system connections using diffusion tensor magnetic resonance imaging (DT-MRI). Ten right-handed healthy subjects (7 males and 3 females, age range 20-51 years) were studied. DT-MRI data were acquired with a voxel size = 2 mm × 2 mm × 2 mm at a 3.0 Tesla clinical MRI scanner. The DT-MRI data were prepared and analyzed using anatomically-guided deterministic tractography methods to reconstruct the SC, DRTC, fronto-ponto-cerebellar (FPC), parieto-ponto-cerebellar (PPC), temporo-ponto-cerebellar (TPC) and occipito-ponto-cerebellar (OPC). The DTI-attributes or the cerebellar tracts along with their cortical representation (Brodmann areas) were presented in standard Montréal Neurological Institute space. All cerebellar tract volumes were quantified and correlated with volumes of cerebral cortical, subcortical gray matter (GM), cerebral WM and cerebellar GM, and cerebellar WM. On our healthy cohort, the ratio of total cerebellar GM-to-WM was ~3.29 ± 0.24, whereas the ratio of cerebral GM-to-WM was approximately 1.10 ± 0.11. The sum of all cerebellar tract volumes is ~25.8 ± 7.3 mL, or a percentage of 1.6 ± 0.45 of the total intracranial volume (ICV).

No MeSH data available.


Related in: MedlinePlus