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Diffusion tensor imaging of the human cerebellar pathways and their interplay with cerebral macrostructure.

Keser Z, Hasan KM, Mwangi BI, Kamali A, Ucisik-Keser FE, Riascos RF, Yozbatiran N, Francisco GE, Narayana PA - Front Neuroanat (2015)

Bottom Line: All cerebellar tract volumes were quantified and correlated with volumes of cerebral cortical, subcortical gray matter (GM), cerebral WM and cerebellar GM, and cerebellar WM.On our healthy cohort, the ratio of total cerebellar GM-to-WM was ~3.29 ± 0.24, whereas the ratio of cerebral GM-to-WM was approximately 1.10 ± 0.11.The sum of all cerebellar tract volumes is ~25.8 ± 7.3 mL, or a percentage of 1.6 ± 0.45 of the total intracranial volume (ICV).

View Article: PubMed Central - PubMed

Affiliation: Department of Physical Medicine and Rehabilitation and TIRR Memorial Hermann Neuro-Recovery Research Center, University of Texas Health Science Center Houston Houston, TX, USA.

ABSTRACT
Cerebellar white matter (WM) connections to the central nervous system are classified functionally into the Spinocerebellar (SC), vestibulocerebellar (VC), and cerebrocerebellar subdivisions. The SC pathways project from spinal cord to cerebellum, whereas the VC pathways project from vestibular organs of the inner ear. Cerebrocerebellar connections are composed of feed forward and feedback connections between cerebrum and cerebellum including the cortico-ponto-cerebellar (CPC) pathways being of cortical origin and the dentate-rubro-thalamo-cortical (DRTC) pathway being of cerebellar origin. In this study we systematically quantified the whole cerebellar system connections using diffusion tensor magnetic resonance imaging (DT-MRI). Ten right-handed healthy subjects (7 males and 3 females, age range 20-51 years) were studied. DT-MRI data were acquired with a voxel size = 2 mm × 2 mm × 2 mm at a 3.0 Tesla clinical MRI scanner. The DT-MRI data were prepared and analyzed using anatomically-guided deterministic tractography methods to reconstruct the SC, DRTC, fronto-ponto-cerebellar (FPC), parieto-ponto-cerebellar (PPC), temporo-ponto-cerebellar (TPC) and occipito-ponto-cerebellar (OPC). The DTI-attributes or the cerebellar tracts along with their cortical representation (Brodmann areas) were presented in standard Montréal Neurological Institute space. All cerebellar tract volumes were quantified and correlated with volumes of cerebral cortical, subcortical gray matter (GM), cerebral WM and cerebellar GM, and cerebellar WM. On our healthy cohort, the ratio of total cerebellar GM-to-WM was ~3.29 ± 0.24, whereas the ratio of cerebral GM-to-WM was approximately 1.10 ± 0.11. The sum of all cerebellar tract volumes is ~25.8 ± 7.3 mL, or a percentage of 1.6 ± 0.45 of the total intracranial volume (ICV).

No MeSH data available.


Related in: MedlinePlus

Relevant structures who have been used in the reconstruction are presented on the fused principal eigenvector map (Red-Green-Blue) and MD (A–E) and Diffusion-weighted image (DWI) non-diffusion (F,G) maps. Abbreviations: DN; Dentate Nucleus, ICP: Inferior Cerebellar Peduncle, MCP: Middle Cerebellar Peduncle, MCPx: Middle Cerebellar Peduncle Crossing, Red N.: Red Nuclei, SCP: Superior Cerebellar Pedunles, SCPx: Superior Cerebellar Pedunles Crossing.
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Figure 2: Relevant structures who have been used in the reconstruction are presented on the fused principal eigenvector map (Red-Green-Blue) and MD (A–E) and Diffusion-weighted image (DWI) non-diffusion (F,G) maps. Abbreviations: DN; Dentate Nucleus, ICP: Inferior Cerebellar Peduncle, MCP: Middle Cerebellar Peduncle, MCPx: Middle Cerebellar Peduncle Crossing, Red N.: Red Nuclei, SCP: Superior Cerebellar Pedunles, SCPx: Superior Cerebellar Pedunles Crossing.

Mentions: SC pathways mainly originate from the spinal cord mainly and pass through the ICP to enter the cerebellum. CPC pathways arising from different parts of the cortex pass through MCP and reach to the cerebellar hemisphere. DRTC pathways emerging from dentate nuclei, together with interposed nuclei, traverse SCP reach to red nucleus and ventroanterior and ventrolateral nuclei (VA/VL) of thalamus then to cortex (Mendoza and Foundas, 2007; Hasan et al., 2009; Snell, 2009; Oishi et al., 2011; see Figure 2).


Diffusion tensor imaging of the human cerebellar pathways and their interplay with cerebral macrostructure.

Keser Z, Hasan KM, Mwangi BI, Kamali A, Ucisik-Keser FE, Riascos RF, Yozbatiran N, Francisco GE, Narayana PA - Front Neuroanat (2015)

Relevant structures who have been used in the reconstruction are presented on the fused principal eigenvector map (Red-Green-Blue) and MD (A–E) and Diffusion-weighted image (DWI) non-diffusion (F,G) maps. Abbreviations: DN; Dentate Nucleus, ICP: Inferior Cerebellar Peduncle, MCP: Middle Cerebellar Peduncle, MCPx: Middle Cerebellar Peduncle Crossing, Red N.: Red Nuclei, SCP: Superior Cerebellar Pedunles, SCPx: Superior Cerebellar Pedunles Crossing.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4389543&req=5

Figure 2: Relevant structures who have been used in the reconstruction are presented on the fused principal eigenvector map (Red-Green-Blue) and MD (A–E) and Diffusion-weighted image (DWI) non-diffusion (F,G) maps. Abbreviations: DN; Dentate Nucleus, ICP: Inferior Cerebellar Peduncle, MCP: Middle Cerebellar Peduncle, MCPx: Middle Cerebellar Peduncle Crossing, Red N.: Red Nuclei, SCP: Superior Cerebellar Pedunles, SCPx: Superior Cerebellar Pedunles Crossing.
Mentions: SC pathways mainly originate from the spinal cord mainly and pass through the ICP to enter the cerebellum. CPC pathways arising from different parts of the cortex pass through MCP and reach to the cerebellar hemisphere. DRTC pathways emerging from dentate nuclei, together with interposed nuclei, traverse SCP reach to red nucleus and ventroanterior and ventrolateral nuclei (VA/VL) of thalamus then to cortex (Mendoza and Foundas, 2007; Hasan et al., 2009; Snell, 2009; Oishi et al., 2011; see Figure 2).

Bottom Line: All cerebellar tract volumes were quantified and correlated with volumes of cerebral cortical, subcortical gray matter (GM), cerebral WM and cerebellar GM, and cerebellar WM.On our healthy cohort, the ratio of total cerebellar GM-to-WM was ~3.29 ± 0.24, whereas the ratio of cerebral GM-to-WM was approximately 1.10 ± 0.11.The sum of all cerebellar tract volumes is ~25.8 ± 7.3 mL, or a percentage of 1.6 ± 0.45 of the total intracranial volume (ICV).

View Article: PubMed Central - PubMed

Affiliation: Department of Physical Medicine and Rehabilitation and TIRR Memorial Hermann Neuro-Recovery Research Center, University of Texas Health Science Center Houston Houston, TX, USA.

ABSTRACT
Cerebellar white matter (WM) connections to the central nervous system are classified functionally into the Spinocerebellar (SC), vestibulocerebellar (VC), and cerebrocerebellar subdivisions. The SC pathways project from spinal cord to cerebellum, whereas the VC pathways project from vestibular organs of the inner ear. Cerebrocerebellar connections are composed of feed forward and feedback connections between cerebrum and cerebellum including the cortico-ponto-cerebellar (CPC) pathways being of cortical origin and the dentate-rubro-thalamo-cortical (DRTC) pathway being of cerebellar origin. In this study we systematically quantified the whole cerebellar system connections using diffusion tensor magnetic resonance imaging (DT-MRI). Ten right-handed healthy subjects (7 males and 3 females, age range 20-51 years) were studied. DT-MRI data were acquired with a voxel size = 2 mm × 2 mm × 2 mm at a 3.0 Tesla clinical MRI scanner. The DT-MRI data were prepared and analyzed using anatomically-guided deterministic tractography methods to reconstruct the SC, DRTC, fronto-ponto-cerebellar (FPC), parieto-ponto-cerebellar (PPC), temporo-ponto-cerebellar (TPC) and occipito-ponto-cerebellar (OPC). The DTI-attributes or the cerebellar tracts along with their cortical representation (Brodmann areas) were presented in standard Montréal Neurological Institute space. All cerebellar tract volumes were quantified and correlated with volumes of cerebral cortical, subcortical gray matter (GM), cerebral WM and cerebellar GM, and cerebellar WM. On our healthy cohort, the ratio of total cerebellar GM-to-WM was ~3.29 ± 0.24, whereas the ratio of cerebral GM-to-WM was approximately 1.10 ± 0.11. The sum of all cerebellar tract volumes is ~25.8 ± 7.3 mL, or a percentage of 1.6 ± 0.45 of the total intracranial volume (ICV).

No MeSH data available.


Related in: MedlinePlus