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Are there gender differences in left ventricular remodeling after myocardial infarction in rats?

Antonio EL, Serra AJ, dos Santos AA, Vieira SS, Silva JM, Yoshizaki A, Sofia RR, Tucci PJ - Rev Bras Cir Cardiovasc (2015 Jan-Mar)

Bottom Line: A P≤=0.05 was considered significant.There were no significant differences between genders for morphometric parameters on first (MI [Female (FE): 44.0 ± 5.0 vs.MA: 4.6 ± 3.4]) week.

View Article: PubMed Central - PubMed

Affiliation: Laboratório de Fisiologia e Fisiopatologia Cardíacas, Universidade Federal de São Paulo, São Paulo, SP, Brazil.

ABSTRACT

Objective: An unclear issue is whether gender may influence at cardiac remodeling after myocardial infarction (MI). We evaluated left ventricle remodeling in female and male rats post-MI.

Methods: Rats were submitted to anterior descending coronary occlusion. Echocardiographic evaluations were performed on the first and sixth week post-occlusion to determine myocardial infarction size and left ventricle systolic function (FAC, fractional area change). Pulsed Doppler was applied to analyze left ventricle diastolic function using the following parameters: E wave, A wave, E/A ratio. Two-way ANOVA was applied for comparisons, complemented by the Bonferroni test. A P≤=0.05 was considered significant.

Results: There were no significant differences between genders for morphometric parameters on first (MI [Female (FE): 44.0 ± 5.0 vs. Male (MA): 42.0 ± 3.0%]; diastolic [FE: 0.04 ± 0.003 vs. MA: 0.037 ± 0.005, mm/g] and systolic [FE: 0.03 ± 0.0004 vs. MA: 0.028 ± 0.005, mm/g] diameters of left ventricle) and sixth (MI [FE: 44.0 ± 5.0 vs. MA: 42.0 ± 3.0, %]; diastolic [FE: 0.043 ± 0.01 vs. MA: 0.034 ± 0.005, mm/g] and systolic [FE: 0.035 ± 0.01 vs. MA: 0.027 ± 0.005, mm/g] of LV) week. Similar findings were reported for left ventricle functional parameters on first (FAC [FE: 34.0 ± 6.0 vs. MA: 32.0 ± 4.0, %]; wave E [FE: 70.0 ± 18.0 vs. MA: 73.0 ± 14.0, cm/s]; wave A [FE: 20.0 ± 12.0 vs. MA: 28.0 ± 13.0, cm/s]; E/A [FE: 4.9 ± 3.4 vs. MA: 3.3 ± 1.8]) and sixth (FAC [FE: 29.0 ± 7.0 vs. MA: 31.0 ± 7.0, %]; wave E [FE: 85.0 ± 18.0 vs. MA: 87.0 ± 20.0, cm/s]; wave A [FE: 20.0 ± 11.0 vs. MA: 28.0 ± 17.0, cm/s]; E/A [FE: 6.2 ± 4.0 vs. MA: 4.6 ± 3.4]) week.

Conclusion: Gender does not influence left ventricle remodeling post-MI in rats.

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Related in: MedlinePlus

Illustrative example of two-dimensional mode traces of the left ventricle(LV) of the female and male rats. Images for mitral inflow velocityprofile determined by pulsed wave Doppler are also shown. Sham rats areplaced on the left, and infarcted rats are placed on the right
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f01: Illustrative example of two-dimensional mode traces of the left ventricle(LV) of the female and male rats. Images for mitral inflow velocityprofile determined by pulsed wave Doppler are also shown. Sham rats areplaced on the left, and infarcted rats are placed on the right

Mentions: Only rats with large infarctions (= 40% of LV) were included for evaluation sincethis is the group that shows the highest severity of thedisease[8]. Thediastolic (DA) and systolic (SA) transverse areas of the LV were measured bytwo-dimensional images on the basal, middle and apical parasternal transverseplanes. The final value was the arithmetic mean of the measurements of the threeviews. Systolic function was analyzed by the fractional area change (FAC=DA -SA/DA, %) in the three transverse planes (basal, middle, and apical). PulsedDoppler at the LV side of the mitral valve provided the flow velocity curve toanalyze the diastolic function parameters (E and A waves and E/A ratio).Echocardiographic images for cardiac effects of MI are shown in Figure 1.


Are there gender differences in left ventricular remodeling after myocardial infarction in rats?

Antonio EL, Serra AJ, dos Santos AA, Vieira SS, Silva JM, Yoshizaki A, Sofia RR, Tucci PJ - Rev Bras Cir Cardiovasc (2015 Jan-Mar)

Illustrative example of two-dimensional mode traces of the left ventricle(LV) of the female and male rats. Images for mitral inflow velocityprofile determined by pulsed wave Doppler are also shown. Sham rats areplaced on the left, and infarcted rats are placed on the right
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4389530&req=5

f01: Illustrative example of two-dimensional mode traces of the left ventricle(LV) of the female and male rats. Images for mitral inflow velocityprofile determined by pulsed wave Doppler are also shown. Sham rats areplaced on the left, and infarcted rats are placed on the right
Mentions: Only rats with large infarctions (= 40% of LV) were included for evaluation sincethis is the group that shows the highest severity of thedisease[8]. Thediastolic (DA) and systolic (SA) transverse areas of the LV were measured bytwo-dimensional images on the basal, middle and apical parasternal transverseplanes. The final value was the arithmetic mean of the measurements of the threeviews. Systolic function was analyzed by the fractional area change (FAC=DA -SA/DA, %) in the three transverse planes (basal, middle, and apical). PulsedDoppler at the LV side of the mitral valve provided the flow velocity curve toanalyze the diastolic function parameters (E and A waves and E/A ratio).Echocardiographic images for cardiac effects of MI are shown in Figure 1.

Bottom Line: A P≤=0.05 was considered significant.There were no significant differences between genders for morphometric parameters on first (MI [Female (FE): 44.0 ± 5.0 vs.MA: 4.6 ± 3.4]) week.

View Article: PubMed Central - PubMed

Affiliation: Laboratório de Fisiologia e Fisiopatologia Cardíacas, Universidade Federal de São Paulo, São Paulo, SP, Brazil.

ABSTRACT

Objective: An unclear issue is whether gender may influence at cardiac remodeling after myocardial infarction (MI). We evaluated left ventricle remodeling in female and male rats post-MI.

Methods: Rats were submitted to anterior descending coronary occlusion. Echocardiographic evaluations were performed on the first and sixth week post-occlusion to determine myocardial infarction size and left ventricle systolic function (FAC, fractional area change). Pulsed Doppler was applied to analyze left ventricle diastolic function using the following parameters: E wave, A wave, E/A ratio. Two-way ANOVA was applied for comparisons, complemented by the Bonferroni test. A P≤=0.05 was considered significant.

Results: There were no significant differences between genders for morphometric parameters on first (MI [Female (FE): 44.0 ± 5.0 vs. Male (MA): 42.0 ± 3.0%]; diastolic [FE: 0.04 ± 0.003 vs. MA: 0.037 ± 0.005, mm/g] and systolic [FE: 0.03 ± 0.0004 vs. MA: 0.028 ± 0.005, mm/g] diameters of left ventricle) and sixth (MI [FE: 44.0 ± 5.0 vs. MA: 42.0 ± 3.0, %]; diastolic [FE: 0.043 ± 0.01 vs. MA: 0.034 ± 0.005, mm/g] and systolic [FE: 0.035 ± 0.01 vs. MA: 0.027 ± 0.005, mm/g] of LV) week. Similar findings were reported for left ventricle functional parameters on first (FAC [FE: 34.0 ± 6.0 vs. MA: 32.0 ± 4.0, %]; wave E [FE: 70.0 ± 18.0 vs. MA: 73.0 ± 14.0, cm/s]; wave A [FE: 20.0 ± 12.0 vs. MA: 28.0 ± 13.0, cm/s]; E/A [FE: 4.9 ± 3.4 vs. MA: 3.3 ± 1.8]) and sixth (FAC [FE: 29.0 ± 7.0 vs. MA: 31.0 ± 7.0, %]; wave E [FE: 85.0 ± 18.0 vs. MA: 87.0 ± 20.0, cm/s]; wave A [FE: 20.0 ± 11.0 vs. MA: 28.0 ± 17.0, cm/s]; E/A [FE: 6.2 ± 4.0 vs. MA: 4.6 ± 3.4]) week.

Conclusion: Gender does not influence left ventricle remodeling post-MI in rats.

Show MeSH
Related in: MedlinePlus