Limits...
Determinants of peak VO2 in heart transplant recipients.

Oliveira Carvalho V, Guimarães GV, Vieira ML, Campos-Vieira ML, Catai AM, Oliveira-Carvalho V, Ayub-Ferreira SM, Bocchi EA - Rev Bras Cir Cardiovasc (2015 Jan-Mar)

Bottom Line: In the second day, patients performed a resting echocardiography.Sixty patients (68% male, 48 years and 64 months following heart transplantation) were assessed.Multivariate analysis showed r=0.77 and r2=0.6 with P <0.001.

View Article: PubMed Central - PubMed

Affiliation: Hospital das Clínicas, Faculdade de Medicina, USP, São Paulo, Brazil.

ABSTRACT

Objective: To establish the determinants of the peak VO2 in heart transplant recipients.

Methods: Patient's assessment was performed in two consecutive days. In the first day, patients performed the heart rate variability assessment followed by a cardiopulmonary exercise test. In the second day, patients performed a resting echocardiography. Heart transplant recipients were eligible if they were in a stable condition and without any evidence of tissue rejection diagnosed by endomyocardial biopsy. Patients with pacemaker, noncardiovascular functional limitations such as osteoarthritis and chronic obstructive pulmonary disease were excluded from this study.

Results: Sixty patients (68% male, 48 years and 64 months following heart transplantation) were assessed. Multivariate analysis selected the following variables: receptor's gender (P=0.001), receptor age (P=0.049), receptor Body Mass Index (P=0.005), heart rate reserve (P <0.0001), left atrium diameter (P=0.016). Multivariate analysis showed r=0.77 and r2=0.6 with P <0.001. Equation: peakVO2=32.851 - 3.708 (receptor gender) - 0.067 (receptor age) - 0.318 (receptor BMI) + 0.145 (heart rate reserve) - 0.111 (left atrium diameter).

Conclusion: The determinants of the peak VO2 in heart transplant recipients were: receptor sex, age, Body Mass Index, heart rate reserve and left atrium diameter. Heart rate reserve was the unique variable positively associated with peak VO2. This data suggest the importance of the sympathetic reinnervation in peak VO2 in heart transplant recipients.

Show MeSH

Related in: MedlinePlus

Patients flow throughout the study
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4389529&req=5

f01: Patients flow throughout the study

Mentions: From 176 heart transplant recipients alive in our service, 109 were not found byphone calls or lived in another city that prevented the realization of theprotocol. Seven patients were excluded due to refusal, pacemaker or sequel ofstroke (Figure 1 ). Sixty patients (68%male, 48 years and 64 months following heart transplantation) were assessed(Table 1 ).


Determinants of peak VO2 in heart transplant recipients.

Oliveira Carvalho V, Guimarães GV, Vieira ML, Campos-Vieira ML, Catai AM, Oliveira-Carvalho V, Ayub-Ferreira SM, Bocchi EA - Rev Bras Cir Cardiovasc (2015 Jan-Mar)

Patients flow throughout the study
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4389529&req=5

f01: Patients flow throughout the study
Mentions: From 176 heart transplant recipients alive in our service, 109 were not found byphone calls or lived in another city that prevented the realization of theprotocol. Seven patients were excluded due to refusal, pacemaker or sequel ofstroke (Figure 1 ). Sixty patients (68%male, 48 years and 64 months following heart transplantation) were assessed(Table 1 ).

Bottom Line: In the second day, patients performed a resting echocardiography.Sixty patients (68% male, 48 years and 64 months following heart transplantation) were assessed.Multivariate analysis showed r=0.77 and r2=0.6 with P <0.001.

View Article: PubMed Central - PubMed

Affiliation: Hospital das Clínicas, Faculdade de Medicina, USP, São Paulo, Brazil.

ABSTRACT

Objective: To establish the determinants of the peak VO2 in heart transplant recipients.

Methods: Patient's assessment was performed in two consecutive days. In the first day, patients performed the heart rate variability assessment followed by a cardiopulmonary exercise test. In the second day, patients performed a resting echocardiography. Heart transplant recipients were eligible if they were in a stable condition and without any evidence of tissue rejection diagnosed by endomyocardial biopsy. Patients with pacemaker, noncardiovascular functional limitations such as osteoarthritis and chronic obstructive pulmonary disease were excluded from this study.

Results: Sixty patients (68% male, 48 years and 64 months following heart transplantation) were assessed. Multivariate analysis selected the following variables: receptor's gender (P=0.001), receptor age (P=0.049), receptor Body Mass Index (P=0.005), heart rate reserve (P <0.0001), left atrium diameter (P=0.016). Multivariate analysis showed r=0.77 and r2=0.6 with P <0.001. Equation: peakVO2=32.851 - 3.708 (receptor gender) - 0.067 (receptor age) - 0.318 (receptor BMI) + 0.145 (heart rate reserve) - 0.111 (left atrium diameter).

Conclusion: The determinants of the peak VO2 in heart transplant recipients were: receptor sex, age, Body Mass Index, heart rate reserve and left atrium diameter. Heart rate reserve was the unique variable positively associated with peak VO2. This data suggest the importance of the sympathetic reinnervation in peak VO2 in heart transplant recipients.

Show MeSH
Related in: MedlinePlus