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The neural correlates of subjectively perceived and passively matched loudness perception in auditory phantom perception.

De Ridder D, Congedo M, Vanneste S - Brain Behav (2015)

Bottom Line: The theta band links gamma band activity in the auditory cortex and parahippocampus via theta-gamma nesting.Apparently the brain generates a network that represents subjectively perceived tinnitus loudness only, which is context dependent.The gamma band activity in the parahippocampus and the auditory cortex is functionally linked via theta-gamma nested lagged phase synchronization.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgical Sciences, Section of Neurosurgery, Dunedin School of Medicine, University of Otago Dunedin, New Zealand ; BRAI²N, Sint Augustinus Hospital Antwerp, Belgium.

ABSTRACT

Introduction: A fundamental question in phantom perception is determining whether the brain creates a network that represents the sound intensity of the auditory phantom as measured by tinnitus matching (in dB), or whether the phantom perception is actually only a representation of the subjectively perceived loudness.

Methods: In tinnitus patients, tinnitus loudness was tested in two ways, by a numeric rating scale for subjectively perceived loudness and a more objective tinnitus-matching test, albeit it is still a subjective measure.

Results: Passively matched tinnitus does not correlate with subjective numeric rating scale, and has no electrophysiological correlates. Subjective loudness, in a whole-brain analysis, is correlated with activity in the left anterior insula (alpha), the rostral/dorsal anterior cingulate cortex (beta), and the left parahippocampus (gamma). A ROI analysis finds correlations with the auditory cortex (high beta and gamma) as well. The theta band links gamma band activity in the auditory cortex and parahippocampus via theta-gamma nesting.

Conclusions: Apparently the brain generates a network that represents subjectively perceived tinnitus loudness only, which is context dependent. The subjective loudness network consists of the anterior cingulate/insula, the parahippocampus, and the auditory cortex. The gamma band activity in the parahippocampus and the auditory cortex is functionally linked via theta-gamma nested lagged phase synchronization.

No MeSH data available.


Related in: MedlinePlus

A significant correlation between the subjective loudness and lagged phased connectivity between the left parahippocampus and the left secondary auditory cortex for the theta frequency band (r = 0.45, P < 0.05).
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fig04: A significant correlation between the subjective loudness and lagged phased connectivity between the left parahippocampus and the left secondary auditory cortex for the theta frequency band (r = 0.45, P < 0.05).

Mentions: A correlation was obtained between the subjectively perceived loudness and lagged phased connectivity between the left parahippocampus and the left secondary auditory cortex for the theta frequency band (r = 0.45, P < 0.05) (see Fig.4). This suggests that a stronger lagged phase connectivity between left parahippocampus and the left secondary auditory cortex is associated with the subjective loudness or vice versa. No significant effect was obtained for delta, alpha, low beta, high beta, and gamma.


The neural correlates of subjectively perceived and passively matched loudness perception in auditory phantom perception.

De Ridder D, Congedo M, Vanneste S - Brain Behav (2015)

A significant correlation between the subjective loudness and lagged phased connectivity between the left parahippocampus and the left secondary auditory cortex for the theta frequency band (r = 0.45, P < 0.05).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4389054&req=5

fig04: A significant correlation between the subjective loudness and lagged phased connectivity between the left parahippocampus and the left secondary auditory cortex for the theta frequency band (r = 0.45, P < 0.05).
Mentions: A correlation was obtained between the subjectively perceived loudness and lagged phased connectivity between the left parahippocampus and the left secondary auditory cortex for the theta frequency band (r = 0.45, P < 0.05) (see Fig.4). This suggests that a stronger lagged phase connectivity between left parahippocampus and the left secondary auditory cortex is associated with the subjective loudness or vice versa. No significant effect was obtained for delta, alpha, low beta, high beta, and gamma.

Bottom Line: The theta band links gamma band activity in the auditory cortex and parahippocampus via theta-gamma nesting.Apparently the brain generates a network that represents subjectively perceived tinnitus loudness only, which is context dependent.The gamma band activity in the parahippocampus and the auditory cortex is functionally linked via theta-gamma nested lagged phase synchronization.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgical Sciences, Section of Neurosurgery, Dunedin School of Medicine, University of Otago Dunedin, New Zealand ; BRAI²N, Sint Augustinus Hospital Antwerp, Belgium.

ABSTRACT

Introduction: A fundamental question in phantom perception is determining whether the brain creates a network that represents the sound intensity of the auditory phantom as measured by tinnitus matching (in dB), or whether the phantom perception is actually only a representation of the subjectively perceived loudness.

Methods: In tinnitus patients, tinnitus loudness was tested in two ways, by a numeric rating scale for subjectively perceived loudness and a more objective tinnitus-matching test, albeit it is still a subjective measure.

Results: Passively matched tinnitus does not correlate with subjective numeric rating scale, and has no electrophysiological correlates. Subjective loudness, in a whole-brain analysis, is correlated with activity in the left anterior insula (alpha), the rostral/dorsal anterior cingulate cortex (beta), and the left parahippocampus (gamma). A ROI analysis finds correlations with the auditory cortex (high beta and gamma) as well. The theta band links gamma band activity in the auditory cortex and parahippocampus via theta-gamma nesting.

Conclusions: Apparently the brain generates a network that represents subjectively perceived tinnitus loudness only, which is context dependent. The subjective loudness network consists of the anterior cingulate/insula, the parahippocampus, and the auditory cortex. The gamma band activity in the parahippocampus and the auditory cortex is functionally linked via theta-gamma nested lagged phase synchronization.

No MeSH data available.


Related in: MedlinePlus