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Relationship between serum 25-hydroxyvitamin D and interleukin-31 levels, and the severity of atopic dermatitis in children.

Cheon BR, Shin JE, Kim YJ, Shim JW, Kim DS, Jung HL, Park MS, Shim JY - Korean J Pediatr (2015)

Bottom Line: The mean 25(OH)D level was significantly lower in the AD group than in the control group; 25(OH)D decreased greatly in the moderate and severe AD groups compared with the mild AD group.Children with moderate and severe AD had significantly higher TECs than children with mild AD.Vitamin D is related to the severity of AD independently of IL-31.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics, Kangbuk Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

ABSTRACT

Purpose: Atopic dermatitis (AD) is a chronic inflammatory relapsing skin disorder. Vitamin D plays a pivotal role in the development of AD, and interleukin (IL) 31 is known to be related to pruritus in AD. The aim of our study was to determine whether 25-hydroxyvitamin D (25(OH)D) levels are related to IL-31 levels or to the severity of AD.

Methods: We enrolled 91 children with AD and 32 control subjects without history or symptoms of allergic diseases. Blood was drawn to evaluate complete blood cell count, total eosinophil count (TEC), and total IgE, specific IgE to common allergens, 25(OH)D, and IL-31 levels. Serum 25(OH)D and IL-31 levels were measured using high-performance liquid chromatography and enzyme-linked immunosorbent assay, respectively. The scoring atopic dermatitis (SCORAD) index was used to evaluate the severity of AD.

Results: The mean 25(OH)D level was significantly lower in the AD group than in the control group; 25(OH)D decreased greatly in the moderate and severe AD groups compared with the mild AD group. Children with atopic sensitization showed significantly lower 25(OH)D levels than nonatopic children. However, serum IL-31 levels were not related to AD group, SCORAD index, or 25(OH)D levels. The SCORAD index was inversely correlated with serum 25(OH)D level and positively correlated with TECs and total IgE levels. Children with moderate and severe AD had significantly higher TECs than children with mild AD.

Conclusion: Vitamin D is related to the severity of AD independently of IL-31.

No MeSH data available.


Related in: MedlinePlus

Correlation between the SCORAD index; serum levels of 25(OH)D, IL-31, and total IgE; and blood eosinophil counts. (A) The 25(OH)D level inversely correlated with the SCORAD index. There was no correlation between 25(OH)D level and IL-31 level (B), or between IL-31 level and the SCORAD index (C). (D) 25(OH)D levels were inversely correlated with total IgE concentrations. The SCORAD index showed a positive correlation with serum total IgE concentration (E) and blood eosinophil count (F). SCORAD index, scoring atopic dermatitis index; 25(OH)D, 25-hydroxyvitamin D; IL, interleukin.
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Figure 2: Correlation between the SCORAD index; serum levels of 25(OH)D, IL-31, and total IgE; and blood eosinophil counts. (A) The 25(OH)D level inversely correlated with the SCORAD index. There was no correlation between 25(OH)D level and IL-31 level (B), or between IL-31 level and the SCORAD index (C). (D) 25(OH)D levels were inversely correlated with total IgE concentrations. The SCORAD index showed a positive correlation with serum total IgE concentration (E) and blood eosinophil count (F). SCORAD index, scoring atopic dermatitis index; 25(OH)D, 25-hydroxyvitamin D; IL, interleukin.

Mentions: We analyzed the relationship between 25(OH)D, IL-31, total IgE, blood eosinophils, and SCORAD index (Fig. 2). Serum 25(OH) D levels showed weak but significant inverse correlations with SCORAD index and serum total IgE level, however it did not correlate with serum IL-31 levels. Serum IL-31 levels also showed no correlation with SCORAD index. The SCORAD index showed a weak correlation with serum total IgE concentration and a strong positive correlation with blood eosinophil counts.


Relationship between serum 25-hydroxyvitamin D and interleukin-31 levels, and the severity of atopic dermatitis in children.

Cheon BR, Shin JE, Kim YJ, Shim JW, Kim DS, Jung HL, Park MS, Shim JY - Korean J Pediatr (2015)

Correlation between the SCORAD index; serum levels of 25(OH)D, IL-31, and total IgE; and blood eosinophil counts. (A) The 25(OH)D level inversely correlated with the SCORAD index. There was no correlation between 25(OH)D level and IL-31 level (B), or between IL-31 level and the SCORAD index (C). (D) 25(OH)D levels were inversely correlated with total IgE concentrations. The SCORAD index showed a positive correlation with serum total IgE concentration (E) and blood eosinophil count (F). SCORAD index, scoring atopic dermatitis index; 25(OH)D, 25-hydroxyvitamin D; IL, interleukin.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4388977&req=5

Figure 2: Correlation between the SCORAD index; serum levels of 25(OH)D, IL-31, and total IgE; and blood eosinophil counts. (A) The 25(OH)D level inversely correlated with the SCORAD index. There was no correlation between 25(OH)D level and IL-31 level (B), or between IL-31 level and the SCORAD index (C). (D) 25(OH)D levels were inversely correlated with total IgE concentrations. The SCORAD index showed a positive correlation with serum total IgE concentration (E) and blood eosinophil count (F). SCORAD index, scoring atopic dermatitis index; 25(OH)D, 25-hydroxyvitamin D; IL, interleukin.
Mentions: We analyzed the relationship between 25(OH)D, IL-31, total IgE, blood eosinophils, and SCORAD index (Fig. 2). Serum 25(OH) D levels showed weak but significant inverse correlations with SCORAD index and serum total IgE level, however it did not correlate with serum IL-31 levels. Serum IL-31 levels also showed no correlation with SCORAD index. The SCORAD index showed a weak correlation with serum total IgE concentration and a strong positive correlation with blood eosinophil counts.

Bottom Line: The mean 25(OH)D level was significantly lower in the AD group than in the control group; 25(OH)D decreased greatly in the moderate and severe AD groups compared with the mild AD group.Children with moderate and severe AD had significantly higher TECs than children with mild AD.Vitamin D is related to the severity of AD independently of IL-31.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics, Kangbuk Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

ABSTRACT

Purpose: Atopic dermatitis (AD) is a chronic inflammatory relapsing skin disorder. Vitamin D plays a pivotal role in the development of AD, and interleukin (IL) 31 is known to be related to pruritus in AD. The aim of our study was to determine whether 25-hydroxyvitamin D (25(OH)D) levels are related to IL-31 levels or to the severity of AD.

Methods: We enrolled 91 children with AD and 32 control subjects without history or symptoms of allergic diseases. Blood was drawn to evaluate complete blood cell count, total eosinophil count (TEC), and total IgE, specific IgE to common allergens, 25(OH)D, and IL-31 levels. Serum 25(OH)D and IL-31 levels were measured using high-performance liquid chromatography and enzyme-linked immunosorbent assay, respectively. The scoring atopic dermatitis (SCORAD) index was used to evaluate the severity of AD.

Results: The mean 25(OH)D level was significantly lower in the AD group than in the control group; 25(OH)D decreased greatly in the moderate and severe AD groups compared with the mild AD group. Children with atopic sensitization showed significantly lower 25(OH)D levels than nonatopic children. However, serum IL-31 levels were not related to AD group, SCORAD index, or 25(OH)D levels. The SCORAD index was inversely correlated with serum 25(OH)D level and positively correlated with TECs and total IgE levels. Children with moderate and severe AD had significantly higher TECs than children with mild AD.

Conclusion: Vitamin D is related to the severity of AD independently of IL-31.

No MeSH data available.


Related in: MedlinePlus