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Does the Mean Arterial Pressure Influence Mortality Rate in Patients with Acute Hypoxemic Respiratory Failure under Mechanical Ventilation?

Gjonbrataj J, Kim HJ, Jung HI, Choi WI - Tuberc Respir Dis (Seoul) (2015)

Bottom Line: In sepsis patients, target mean arterial pressures (MAPs) greater than 65 mm Hg are recommended.At 60 days, the mortality rates in the low (26.2%) and high (24.5%) MAP groups were not significantly different.The ICU days, hospital days, and 60-day mortality rate did not differ between the groups.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea. ; Department of Internal Medicine, Mother Thereza University Hospital, Tirana, Albania.

ABSTRACT

Background: In sepsis patients, target mean arterial pressures (MAPs) greater than 65 mm Hg are recommended. However, there is no such recommendation for patients receiving mechanical ventilation. We aimed to evaluate the influence of MAP over the first 24 hours after intensive care unit (ICU) admission on the mortality rate at 60 days post-admission in patients showing acute hypoxemic respiratory failure under mechanical ventilation.

Methods: This prospective, multicenter study included 22 ICUs and compared the mortality and clinical outcomes in patients showing acute hypoxemic respiratory failure with high (75-90 mm Hg) and low (65-74.9 mm Hg) MAPs over the first 24 hours of admission to the ICU.

Results: Of the 844 patients with acute hypoxemic respiratory failure, 338 had a sustained MAP of 65-90 mm Hg over the first 24 hours of admission to the ICU. At 60 days, the mortality rates in the low (26.2%) and high (24.5%) MAP groups were not significantly different. The ICU days, hospital days, and 60-day mortality rate did not differ between the groups.

Conclusion: In the first 24 hours of ICU admission, MAP range between 65 and 90 mm Hg in patients with acute hypoxemic respiratory failure under mechanical ventilation may not cause significantly differences in 60-day mortality.

No MeSH data available.


Related in: MedlinePlus

Kaplan-Meier survival curves: patients with low mean arterial pressure (MAP) (65-74.9 mm Hg) (solid line) compared to patients with high MAP (75-89.9 mm Hg) (dotted line).
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Figure 2: Kaplan-Meier survival curves: patients with low mean arterial pressure (MAP) (65-74.9 mm Hg) (solid line) compared to patients with high MAP (75-89.9 mm Hg) (dotted line).

Mentions: The Kaplan-Meier survival curves demonstrated the same survival rates for patients with high and low MAP over the first 24 hours of admission to the ICU. The 60-day mortality rate was approximately 60% for both study groups (Figure 2).


Does the Mean Arterial Pressure Influence Mortality Rate in Patients with Acute Hypoxemic Respiratory Failure under Mechanical Ventilation?

Gjonbrataj J, Kim HJ, Jung HI, Choi WI - Tuberc Respir Dis (Seoul) (2015)

Kaplan-Meier survival curves: patients with low mean arterial pressure (MAP) (65-74.9 mm Hg) (solid line) compared to patients with high MAP (75-89.9 mm Hg) (dotted line).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4388905&req=5

Figure 2: Kaplan-Meier survival curves: patients with low mean arterial pressure (MAP) (65-74.9 mm Hg) (solid line) compared to patients with high MAP (75-89.9 mm Hg) (dotted line).
Mentions: The Kaplan-Meier survival curves demonstrated the same survival rates for patients with high and low MAP over the first 24 hours of admission to the ICU. The 60-day mortality rate was approximately 60% for both study groups (Figure 2).

Bottom Line: In sepsis patients, target mean arterial pressures (MAPs) greater than 65 mm Hg are recommended.At 60 days, the mortality rates in the low (26.2%) and high (24.5%) MAP groups were not significantly different.The ICU days, hospital days, and 60-day mortality rate did not differ between the groups.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea. ; Department of Internal Medicine, Mother Thereza University Hospital, Tirana, Albania.

ABSTRACT

Background: In sepsis patients, target mean arterial pressures (MAPs) greater than 65 mm Hg are recommended. However, there is no such recommendation for patients receiving mechanical ventilation. We aimed to evaluate the influence of MAP over the first 24 hours after intensive care unit (ICU) admission on the mortality rate at 60 days post-admission in patients showing acute hypoxemic respiratory failure under mechanical ventilation.

Methods: This prospective, multicenter study included 22 ICUs and compared the mortality and clinical outcomes in patients showing acute hypoxemic respiratory failure with high (75-90 mm Hg) and low (65-74.9 mm Hg) MAPs over the first 24 hours of admission to the ICU.

Results: Of the 844 patients with acute hypoxemic respiratory failure, 338 had a sustained MAP of 65-90 mm Hg over the first 24 hours of admission to the ICU. At 60 days, the mortality rates in the low (26.2%) and high (24.5%) MAP groups were not significantly different. The ICU days, hospital days, and 60-day mortality rate did not differ between the groups.

Conclusion: In the first 24 hours of ICU admission, MAP range between 65 and 90 mm Hg in patients with acute hypoxemic respiratory failure under mechanical ventilation may not cause significantly differences in 60-day mortality.

No MeSH data available.


Related in: MedlinePlus