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Two cases of bronchopulmonary dysplasia of similar appearance in adult monozygotic twin: pathology and computed tomographic findings.

Lee YP, Chun EM, Kim YK, Sung SH - Tuberc Respir Dis (Seoul) (2015)

Bottom Line: They had common histories of pneumonias requiring mechanical ventilations in period of infants.Pathologic findings showed bronchiolar hyperplasia and peribronchiolar fibrosis which was similar to classic BPD patients.It might be reasonable to make close follow-up for BPD patients to evaluate the long-term outcomes of BPD survivors.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, Korea.

ABSTRACT
Bronchopulmonary dysplasia (BPD) is related to decreased lung function throughout life. However, the pathology and radiology pattern of BPD of adults are not documented well yet. In this case report, we present BPD case of an adult monozygotic twin showing nearly identical lesions on chest computed tomography (CT). CT images showed mixed areas of ground-glass and reticular opacities in both lungs. They had common histories of pneumonias requiring mechanical ventilations in period of infants. Pulmonary function test of one patient showed a pulmonary insufficiency with airway obstruction. Pathologic findings showed bronchiolar hyperplasia and peribronchiolar fibrosis which was similar to classic BPD patients. Our twin case report might help provide distinguishing pathology and radiology pattern of an adult pulmonary sequelaes of BPD. It might be reasonable to make close follow-up for BPD patients to evaluate the long-term outcomes of BPD survivors.

No MeSH data available.


Related in: MedlinePlus

A low dose chest computed tomographic (CT) findings of 29-year-old man. (A) Posterior-anterior chest radiograph showing peribronchovascular increased opacities in both lungs. (B, C) CT scans (2-mm slice low-dose CT; lung window images with window level of-700 Hounsfield unit (HU) and window width of 1,500 HU) showing areas of mixed ground-glass and reticular opacities in both lungs, predominantly in the central and peribronchovascular areas.
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Figure 1: A low dose chest computed tomographic (CT) findings of 29-year-old man. (A) Posterior-anterior chest radiograph showing peribronchovascular increased opacities in both lungs. (B, C) CT scans (2-mm slice low-dose CT; lung window images with window level of-700 Hounsfield unit (HU) and window width of 1,500 HU) showing areas of mixed ground-glass and reticular opacities in both lungs, predominantly in the central and peribronchovascular areas.

Mentions: The patient's chest posteroanterior radiograph showed symmetrically increased peribronchovascular opacities in both lungs. He underwent a low-dose CT scan (120 kVp and 30 mAs; 2-mm slice thickness) of the thorax, and CT images showed mixed areas of ground-glass and reticular opacities in both lungs, predominantly along central and peribronchovascular areas (Figure 1). The patient was admitted for diagnosis and treatment as the chest CT findings suggested the possibility of interstitial lung disease. For definitive diagnosis, VATS wedge resection for tissue confirm was scheduled and several serologic tests for viral and atypical pathogens were also performed. Additionally, antibiotics were switched to intravenous piperacillin-tazobactam, and steroid therapy with methylprednisolone (32.5 mg intravenous Q12hr) was also administrated to improve respiratory symptoms and radiologic findings. VATS was performed on fourth day of admission. The superior segment of left lower lobe was resected with visual identification of the consolidation.


Two cases of bronchopulmonary dysplasia of similar appearance in adult monozygotic twin: pathology and computed tomographic findings.

Lee YP, Chun EM, Kim YK, Sung SH - Tuberc Respir Dis (Seoul) (2015)

A low dose chest computed tomographic (CT) findings of 29-year-old man. (A) Posterior-anterior chest radiograph showing peribronchovascular increased opacities in both lungs. (B, C) CT scans (2-mm slice low-dose CT; lung window images with window level of-700 Hounsfield unit (HU) and window width of 1,500 HU) showing areas of mixed ground-glass and reticular opacities in both lungs, predominantly in the central and peribronchovascular areas.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4388897&req=5

Figure 1: A low dose chest computed tomographic (CT) findings of 29-year-old man. (A) Posterior-anterior chest radiograph showing peribronchovascular increased opacities in both lungs. (B, C) CT scans (2-mm slice low-dose CT; lung window images with window level of-700 Hounsfield unit (HU) and window width of 1,500 HU) showing areas of mixed ground-glass and reticular opacities in both lungs, predominantly in the central and peribronchovascular areas.
Mentions: The patient's chest posteroanterior radiograph showed symmetrically increased peribronchovascular opacities in both lungs. He underwent a low-dose CT scan (120 kVp and 30 mAs; 2-mm slice thickness) of the thorax, and CT images showed mixed areas of ground-glass and reticular opacities in both lungs, predominantly along central and peribronchovascular areas (Figure 1). The patient was admitted for diagnosis and treatment as the chest CT findings suggested the possibility of interstitial lung disease. For definitive diagnosis, VATS wedge resection for tissue confirm was scheduled and several serologic tests for viral and atypical pathogens were also performed. Additionally, antibiotics were switched to intravenous piperacillin-tazobactam, and steroid therapy with methylprednisolone (32.5 mg intravenous Q12hr) was also administrated to improve respiratory symptoms and radiologic findings. VATS was performed on fourth day of admission. The superior segment of left lower lobe was resected with visual identification of the consolidation.

Bottom Line: They had common histories of pneumonias requiring mechanical ventilations in period of infants.Pathologic findings showed bronchiolar hyperplasia and peribronchiolar fibrosis which was similar to classic BPD patients.It might be reasonable to make close follow-up for BPD patients to evaluate the long-term outcomes of BPD survivors.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, Korea.

ABSTRACT
Bronchopulmonary dysplasia (BPD) is related to decreased lung function throughout life. However, the pathology and radiology pattern of BPD of adults are not documented well yet. In this case report, we present BPD case of an adult monozygotic twin showing nearly identical lesions on chest computed tomography (CT). CT images showed mixed areas of ground-glass and reticular opacities in both lungs. They had common histories of pneumonias requiring mechanical ventilations in period of infants. Pulmonary function test of one patient showed a pulmonary insufficiency with airway obstruction. Pathologic findings showed bronchiolar hyperplasia and peribronchiolar fibrosis which was similar to classic BPD patients. Our twin case report might help provide distinguishing pathology and radiology pattern of an adult pulmonary sequelaes of BPD. It might be reasonable to make close follow-up for BPD patients to evaluate the long-term outcomes of BPD survivors.

No MeSH data available.


Related in: MedlinePlus