Limits...
A case of solitary fibrous pleura tumor associated with severe hypoglycemia: doege-potter syndrome.

Jang JG, Chung JH, Hong KS, Ahn JH, Lee JY, Jo JH, Lee DW, Shin KC, Lee KH, Kim MJ, Lee JC, Lee JH, Lee JK - Tuberc Respir Dis (Seoul) (2015)

Bottom Line: It usually has an indolent clinical course.The hypoglycemia that accompanies SFTP was first described by Doege and Potter independently in 1930, hence the eponym Doege-Potter syndrome (DPS).The incidence of DPS is reported to be ~4%.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Regional Center for Respiratory Disease, Yeungnam University Medical Center, Yeungnam University College of Medicine, Daegu, Korea.

ABSTRACT
Solitary fibrous tumor of the pleura (SFTP) is a rare primary intrathoracic tumor that arises from mesenchymal tissue underlying the mesothelial layer of the pleura. It usually has an indolent clinical course. The hypoglycemia that accompanies SFTP was first described by Doege and Potter independently in 1930, hence the eponym Doege-Potter syndrome (DPS). The incidence of DPS is reported to be ~4%. In this report, we present a typical case of DPS that was cured through complete surgical resection.

No MeSH data available.


Related in: MedlinePlus

The tumor cells were immunohistochemically strongly reactive for Bcl-2 (A), CD34 (B), and STAT6 (C) a specific marker for solitary fibrous tumors (A-C, ×200).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4388895&req=5

Figure 4: The tumor cells were immunohistochemically strongly reactive for Bcl-2 (A), CD34 (B), and STAT6 (C) a specific marker for solitary fibrous tumors (A-C, ×200).

Mentions: The histological finding was proliferation of spindle cells with a storiform-like and fascicular arrangement. The nuclear features showed a monotonous appearance. We also noted focal mild to moderate pleomorphism, and increased cellularity. The mitotic activity averaged 10-12 mitotic figures per 10 high-power fields (Figure 3). The tumor cells were immunohistochemically positive for CD34, Bcl-2, and STAT6, and negative for S-100 protein, CD117, actin, desmin, calretinin, D240, WT-1, and cytokeratin 5/6 (Figure 4). Based on the microscopic appearance of the immunohistological pattern, a final diagnosis of malignant SFTP was made.


A case of solitary fibrous pleura tumor associated with severe hypoglycemia: doege-potter syndrome.

Jang JG, Chung JH, Hong KS, Ahn JH, Lee JY, Jo JH, Lee DW, Shin KC, Lee KH, Kim MJ, Lee JC, Lee JH, Lee JK - Tuberc Respir Dis (Seoul) (2015)

The tumor cells were immunohistochemically strongly reactive for Bcl-2 (A), CD34 (B), and STAT6 (C) a specific marker for solitary fibrous tumors (A-C, ×200).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4388895&req=5

Figure 4: The tumor cells were immunohistochemically strongly reactive for Bcl-2 (A), CD34 (B), and STAT6 (C) a specific marker for solitary fibrous tumors (A-C, ×200).
Mentions: The histological finding was proliferation of spindle cells with a storiform-like and fascicular arrangement. The nuclear features showed a monotonous appearance. We also noted focal mild to moderate pleomorphism, and increased cellularity. The mitotic activity averaged 10-12 mitotic figures per 10 high-power fields (Figure 3). The tumor cells were immunohistochemically positive for CD34, Bcl-2, and STAT6, and negative for S-100 protein, CD117, actin, desmin, calretinin, D240, WT-1, and cytokeratin 5/6 (Figure 4). Based on the microscopic appearance of the immunohistological pattern, a final diagnosis of malignant SFTP was made.

Bottom Line: It usually has an indolent clinical course.The hypoglycemia that accompanies SFTP was first described by Doege and Potter independently in 1930, hence the eponym Doege-Potter syndrome (DPS).The incidence of DPS is reported to be ~4%.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Regional Center for Respiratory Disease, Yeungnam University Medical Center, Yeungnam University College of Medicine, Daegu, Korea.

ABSTRACT
Solitary fibrous tumor of the pleura (SFTP) is a rare primary intrathoracic tumor that arises from mesenchymal tissue underlying the mesothelial layer of the pleura. It usually has an indolent clinical course. The hypoglycemia that accompanies SFTP was first described by Doege and Potter independently in 1930, hence the eponym Doege-Potter syndrome (DPS). The incidence of DPS is reported to be ~4%. In this report, we present a typical case of DPS that was cured through complete surgical resection.

No MeSH data available.


Related in: MedlinePlus