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Sinus penetration of saline solution irrigation and atomizer in a cadaveric polyp and allergic fungal sinusitis model.

Doellman M, Chen PG, McMains KC, Sarber KM, Weitzel EK - Allergy Rhinol (Providence) (2015)

Bottom Line: Delivery of topical medication is paramount in these patients, but the most difficult to accomplish.We investigated heavy irrigation (nasal douche) and atomized medication delivery potential in a cadaveric sinus model of polypoid AFS disease.The maxillary sinus showed the best irrigation and overall the heavy irrigator was more efficient than the atomizer.

View Article: PubMed Central - PubMed

Affiliation: Department of Otolaryngology - Head and Neck Surgery, San Antonio Military Medical Center, Fort Sam, Houston, Texas, USA.

ABSTRACT
Allergic fungal sinusitis (AFS) is a stubborn disease requiring surgical and medical management. Delivery of topical medication is paramount in these patients, but the most difficult to accomplish. We investigated heavy irrigation (nasal douche) and atomized medication delivery potential in a cadaveric sinus model of polypoid AFS disease. Three disease models were created: a control that involved unoperated sinuses and no simulated disease; an unoperated AFS with type II polyposis mode; and an operated model with recurrent allergic fungal sinusitis with type II polyposis. The maxillary sinus showed the best irrigation and overall the heavy irrigator was more efficient than the atomizer.

No MeSH data available.


Related in: MedlinePlus

Degree of penetration for frontal sinuses subtyped by irrigation system, based on a 0–5 visual scale.
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Figure 1: Degree of penetration for frontal sinuses subtyped by irrigation system, based on a 0–5 visual scale.

Mentions: Analysis of penetration magnitude data (Fig. 1) showed increased irrigation penetration for both irrigation (p = 0.001) and atomizer (p = 0.05). Post hoc testing revealed a significant increase in penetration between conditions 1 and 2 (p = 0.016) and conditions 1 and 3 (p = 0.016) for heavy irrigator penetration. Analysis of atomizer data did not demonstrate statistically significant penetration potential on post hoc testing between conditions 1 and 2 (p = 0.083) or conditions 1 and 3 (p = 0.083). Frequency data (Fig. 2) similarly displayed increased irrigation potential for both irrigation (p = 0.004) and atomizer (p = 0.05). Results of post hoc testing on irrigation data again showed significantly greater irrigation penetration in condition 1 than in condition 2 (p = 0.025) and condition 1 than in condition 3 (p = 0.008). Results of post hoc testing for the atomizer demonstrated significant differences between conditions 1 and 2 (p = 0.083) and conditions 1 and 3 (p = 0.083). Magnitude or frequency that compared the two diseased states (conditions 2 and 3) failed to show statistically significant differences in frontal penetration for either atomizer or irrigation.


Sinus penetration of saline solution irrigation and atomizer in a cadaveric polyp and allergic fungal sinusitis model.

Doellman M, Chen PG, McMains KC, Sarber KM, Weitzel EK - Allergy Rhinol (Providence) (2015)

Degree of penetration for frontal sinuses subtyped by irrigation system, based on a 0–5 visual scale.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4388882&req=5

Figure 1: Degree of penetration for frontal sinuses subtyped by irrigation system, based on a 0–5 visual scale.
Mentions: Analysis of penetration magnitude data (Fig. 1) showed increased irrigation penetration for both irrigation (p = 0.001) and atomizer (p = 0.05). Post hoc testing revealed a significant increase in penetration between conditions 1 and 2 (p = 0.016) and conditions 1 and 3 (p = 0.016) for heavy irrigator penetration. Analysis of atomizer data did not demonstrate statistically significant penetration potential on post hoc testing between conditions 1 and 2 (p = 0.083) or conditions 1 and 3 (p = 0.083). Frequency data (Fig. 2) similarly displayed increased irrigation potential for both irrigation (p = 0.004) and atomizer (p = 0.05). Results of post hoc testing on irrigation data again showed significantly greater irrigation penetration in condition 1 than in condition 2 (p = 0.025) and condition 1 than in condition 3 (p = 0.008). Results of post hoc testing for the atomizer demonstrated significant differences between conditions 1 and 2 (p = 0.083) and conditions 1 and 3 (p = 0.083). Magnitude or frequency that compared the two diseased states (conditions 2 and 3) failed to show statistically significant differences in frontal penetration for either atomizer or irrigation.

Bottom Line: Delivery of topical medication is paramount in these patients, but the most difficult to accomplish.We investigated heavy irrigation (nasal douche) and atomized medication delivery potential in a cadaveric sinus model of polypoid AFS disease.The maxillary sinus showed the best irrigation and overall the heavy irrigator was more efficient than the atomizer.

View Article: PubMed Central - PubMed

Affiliation: Department of Otolaryngology - Head and Neck Surgery, San Antonio Military Medical Center, Fort Sam, Houston, Texas, USA.

ABSTRACT
Allergic fungal sinusitis (AFS) is a stubborn disease requiring surgical and medical management. Delivery of topical medication is paramount in these patients, but the most difficult to accomplish. We investigated heavy irrigation (nasal douche) and atomized medication delivery potential in a cadaveric sinus model of polypoid AFS disease. Three disease models were created: a control that involved unoperated sinuses and no simulated disease; an unoperated AFS with type II polyposis mode; and an operated model with recurrent allergic fungal sinusitis with type II polyposis. The maxillary sinus showed the best irrigation and overall the heavy irrigator was more efficient than the atomizer.

No MeSH data available.


Related in: MedlinePlus