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Synthesis and anti-fungal effect of silver nanoparticles-chitosan composite particles.

Wang LS, Wang CY, Yang CH, Hsieh CL, Chen SY, Shen CY, Wang JJ, Huang KS - Int J Nanomedicine (2015)

Bottom Line: The diameter of the synthesized chitosan composite particles ranged from 1.7 mm to 2.5 mm, and the embedded silver nanoparticles were measured to be 15 ± 3.3 nm.The results show that the silver nanoparticles were distributed over the surface and interior of the chitosan spheres.The fabricated spheres had macroporous property, and could be used for many applications such as fungicidal agents in the future.

View Article: PubMed Central - PubMed

Affiliation: Department of Electrical Engineering, I-Shou University, Kaohsiung, Taiwan ; Department of Biomedical Engineering, I-Shou University, Kaohsiung, Taiwan ; The School of Chinese Medicine for Post-Baccalaureate, I-Shou University, Kaohsiung, Taiwan ; Department of Chinese Medicine, E-Da Hospital, Kaohsiung, Taiwan.

ABSTRACT
Silver nanoparticles have been used in various fields, and several synthesis processes have been developed. The stability and dispersion of the synthesized nanoparticles is vital. The present article describes a novel approach for one-step synthesis of silver nanoparticles-embedded chitosan particles. The proposed approach was applied to simultaneously obtain and stabilize silver nanoparticles in a chitosan polymer matrix in-situ. The diameter of the synthesized chitosan composite particles ranged from 1.7 mm to 2.5 mm, and the embedded silver nanoparticles were measured to be 15 ± 3.3 nm. Further, the analyses of ultraviolet-visible spectroscopy, energy dispersive spectroscopy, and X-ray diffraction were employed to characterize the prepared composites. The results show that the silver nanoparticles were distributed over the surface and interior of the chitosan spheres. The fabricated spheres had macroporous property, and could be used for many applications such as fungicidal agents in the future.

No MeSH data available.


Photographs of the synthesized spheres.Notes: (A) Chitosan spheres. (B) Silver nanoparticles–chitosan composite spheres synthesized with 1 mM AgNO3. (C) Silver nanoparticles–chitosan composite spheres synthesized with 8 mM AgNO3. The concentration of chitosan was 2%. All scale bars are 2 mm.Abbreviation: AgNO3, silver nitrate.
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f2-ijn-10-2685: Photographs of the synthesized spheres.Notes: (A) Chitosan spheres. (B) Silver nanoparticles–chitosan composite spheres synthesized with 1 mM AgNO3. (C) Silver nanoparticles–chitosan composite spheres synthesized with 8 mM AgNO3. The concentration of chitosan was 2%. All scale bars are 2 mm.Abbreviation: AgNO3, silver nitrate.

Mentions: Figure 2 shows that the silver nanoparticles–chitosan composite spheres are obtained by using various concentrations of AgNO3. The pure chitosan spheres showed milky-white (Figure 2A), whereas the fabricated spheres showed more gray when the concentration of AgNO3 (Figure 2B) was lower, and more khaki when the concentration of AgNO3 was higher (Figure 2C). The color variation provided some clues to the formation of silver nanoparticles.45 Highly coherent appearance of the prepared silver nanoparticles–chitosan composite spheres was obtained when various concentrations of AgNO3 were used. However, the diameter of the silver nanoparticles seemed to decrease with an increasing concentration of AgNO3 (Table 1). Most of the relative standard deviations of the sphere diameters observed at various concentrations of AgNO3 were less than 10%, indicating that the manufactured spheres met the typical criterion for monodispersity.46 Results shown in Figure 2 illustrate the composite spheres fabricated with low concentrations of AgNO3 were slightly flattened in contact with the plate bottom, and thus they became slightly enlarged when measured by a top view. This phenomenon occurred because of fewer silver nanoparticles decreasing the mechanical strength of the spheres. In contrast, when the composite spheres were fabricated with high concentrations of AgNO3 (there will be more silver nanoparticles formed), the composite spheres presented a superior mechanical strength, and thus exhibited properties such as easy spheroidization and aversion to deformation and fragmentation. The literature related to the fabrication of silver nanoparticles–chitosan composite films has mentioned that silver nanoparticles were uniformly dispersed and captured by the networks of amine (-NH2) and hydroxyl (-OH) functional groups,47 and thus the mechanical strength could be enhanced.48,49 Those results were consistent with our finding. We presume that the silver nanoparticles in silver nanoparticles–polymer composite play an identical role of cramp bar in architecture to reinforced concrete. Concrete (imagine as polymer) has relatively low tensile strength, while the presence of reinforcing bars (imagine as silver nanoparticles) shows higher tensile strength and/or ductility.


Synthesis and anti-fungal effect of silver nanoparticles-chitosan composite particles.

Wang LS, Wang CY, Yang CH, Hsieh CL, Chen SY, Shen CY, Wang JJ, Huang KS - Int J Nanomedicine (2015)

Photographs of the synthesized spheres.Notes: (A) Chitosan spheres. (B) Silver nanoparticles–chitosan composite spheres synthesized with 1 mM AgNO3. (C) Silver nanoparticles–chitosan composite spheres synthesized with 8 mM AgNO3. The concentration of chitosan was 2%. All scale bars are 2 mm.Abbreviation: AgNO3, silver nitrate.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4388074&req=5

f2-ijn-10-2685: Photographs of the synthesized spheres.Notes: (A) Chitosan spheres. (B) Silver nanoparticles–chitosan composite spheres synthesized with 1 mM AgNO3. (C) Silver nanoparticles–chitosan composite spheres synthesized with 8 mM AgNO3. The concentration of chitosan was 2%. All scale bars are 2 mm.Abbreviation: AgNO3, silver nitrate.
Mentions: Figure 2 shows that the silver nanoparticles–chitosan composite spheres are obtained by using various concentrations of AgNO3. The pure chitosan spheres showed milky-white (Figure 2A), whereas the fabricated spheres showed more gray when the concentration of AgNO3 (Figure 2B) was lower, and more khaki when the concentration of AgNO3 was higher (Figure 2C). The color variation provided some clues to the formation of silver nanoparticles.45 Highly coherent appearance of the prepared silver nanoparticles–chitosan composite spheres was obtained when various concentrations of AgNO3 were used. However, the diameter of the silver nanoparticles seemed to decrease with an increasing concentration of AgNO3 (Table 1). Most of the relative standard deviations of the sphere diameters observed at various concentrations of AgNO3 were less than 10%, indicating that the manufactured spheres met the typical criterion for monodispersity.46 Results shown in Figure 2 illustrate the composite spheres fabricated with low concentrations of AgNO3 were slightly flattened in contact with the plate bottom, and thus they became slightly enlarged when measured by a top view. This phenomenon occurred because of fewer silver nanoparticles decreasing the mechanical strength of the spheres. In contrast, when the composite spheres were fabricated with high concentrations of AgNO3 (there will be more silver nanoparticles formed), the composite spheres presented a superior mechanical strength, and thus exhibited properties such as easy spheroidization and aversion to deformation and fragmentation. The literature related to the fabrication of silver nanoparticles–chitosan composite films has mentioned that silver nanoparticles were uniformly dispersed and captured by the networks of amine (-NH2) and hydroxyl (-OH) functional groups,47 and thus the mechanical strength could be enhanced.48,49 Those results were consistent with our finding. We presume that the silver nanoparticles in silver nanoparticles–polymer composite play an identical role of cramp bar in architecture to reinforced concrete. Concrete (imagine as polymer) has relatively low tensile strength, while the presence of reinforcing bars (imagine as silver nanoparticles) shows higher tensile strength and/or ductility.

Bottom Line: The diameter of the synthesized chitosan composite particles ranged from 1.7 mm to 2.5 mm, and the embedded silver nanoparticles were measured to be 15 ± 3.3 nm.The results show that the silver nanoparticles were distributed over the surface and interior of the chitosan spheres.The fabricated spheres had macroporous property, and could be used for many applications such as fungicidal agents in the future.

View Article: PubMed Central - PubMed

Affiliation: Department of Electrical Engineering, I-Shou University, Kaohsiung, Taiwan ; Department of Biomedical Engineering, I-Shou University, Kaohsiung, Taiwan ; The School of Chinese Medicine for Post-Baccalaureate, I-Shou University, Kaohsiung, Taiwan ; Department of Chinese Medicine, E-Da Hospital, Kaohsiung, Taiwan.

ABSTRACT
Silver nanoparticles have been used in various fields, and several synthesis processes have been developed. The stability and dispersion of the synthesized nanoparticles is vital. The present article describes a novel approach for one-step synthesis of silver nanoparticles-embedded chitosan particles. The proposed approach was applied to simultaneously obtain and stabilize silver nanoparticles in a chitosan polymer matrix in-situ. The diameter of the synthesized chitosan composite particles ranged from 1.7 mm to 2.5 mm, and the embedded silver nanoparticles were measured to be 15 ± 3.3 nm. Further, the analyses of ultraviolet-visible spectroscopy, energy dispersive spectroscopy, and X-ray diffraction were employed to characterize the prepared composites. The results show that the silver nanoparticles were distributed over the surface and interior of the chitosan spheres. The fabricated spheres had macroporous property, and could be used for many applications such as fungicidal agents in the future.

No MeSH data available.