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Histopathological, ultrastructural, and immunohistochemical assessment of hippocampus structures of rats exposed to TCDD and high doses of tocopherol and acetylsalicylic acid.

Rosińczuk J, Dymarek R, Całkosiński I - Biomed Res Int (2015)

Bottom Line: The aim of the study was to determine the effect of dioxins on function, ultrastructure, and cytological and histological structure of hippocampus, particularly on expression of estrogen receptors in central nervous system as well as to define protective influence of tocopherol (TCP) and acetylsalicylic acid (ASA) on the decrease in activity of proinflammatory effects in central nervous system.Histopathological and ultrastructural image of hippocampus areas in rats, in which both TCP and ASA were used, is characterized by poorly expressed degenerative changes and smaller inflammatory reactivity.Using both TCP and ASA has a protective effect on functions of central nervous system.

View Article: PubMed Central - PubMed

Affiliation: Department of Nervous System Diseases, The Faculty of Health Science, Wroclaw Medical University, Bartla 5 Street, 51-618 Wrocław, Poland.

ABSTRACT
The effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on central nervous system consists of changing expression of estrogen receptors, whereas the result of chronic inflammatory reaction caused by dioxin is occurrence of destructive changes in various organs connected with disturbed metabolism of connective tissue and damage of cells. The aim of the study was to determine the effect of dioxins on function, ultrastructure, and cytological and histological structure of hippocampus, particularly on expression of estrogen receptors in central nervous system as well as to define protective influence of tocopherol (TCP) and acetylsalicylic acid (ASA) on the decrease in activity of proinflammatory effects in central nervous system. It was shown that TCDD contributes to destructive and inflammatory changes along with demyelization of myelin sheaths and atrophy of estrogen receptors in hippocampus. Dioxin contributes to atrophy of estrogen receptors in hippocampus, in which also destructive and inflammatory changes were found along with demyelination of myelin sheaths. Histopathological and ultrastructural image of hippocampus areas in rats, in which both TCP and ASA were used, is characterized by poorly expressed degenerative changes and smaller inflammatory reactivity. Using both TCP and ASA has a protective effect on functions of central nervous system.

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Histological image of dentate gyrus in animals in group IP (enlargement 400x). Basically correct image of structure with clear marking of the net of capillary blood vessels (1); in the lumen of capillary vessel numerous erythrocytes forming rouleau are shown, whose presence may indicate venostasis; near the above mentioned vessels there are macrophages and microglia cells present (2).
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fig8: Histological image of dentate gyrus in animals in group IP (enlargement 400x). Basically correct image of structure with clear marking of the net of capillary blood vessels (1); in the lumen of capillary vessel numerous erythrocytes forming rouleau are shown, whose presence may indicate venostasis; near the above mentioned vessels there are macrophages and microglia cells present (2).

Mentions: In control group with induced pleuritis IP (Figure 8) main changes occurring in the area of dentate gyrus concern granular and pyramidal layer. To a smaller extent they apply to molecular layer. The nature of changes is like in the area of Ammon's horn but the degree of those changes is bigger particularly in the layer of pyramidal cells. In the layer of granular cells a bigger glial proliferation than in Ammon's horn can be observed. In the lumen of capillary vessels rouleau formation of erythrocytes is found which may prove hemostasis in blood vessels. Most clear changes of degenerative nature were observed in molecular layer.


Histopathological, ultrastructural, and immunohistochemical assessment of hippocampus structures of rats exposed to TCDD and high doses of tocopherol and acetylsalicylic acid.

Rosińczuk J, Dymarek R, Całkosiński I - Biomed Res Int (2015)

Histological image of dentate gyrus in animals in group IP (enlargement 400x). Basically correct image of structure with clear marking of the net of capillary blood vessels (1); in the lumen of capillary vessel numerous erythrocytes forming rouleau are shown, whose presence may indicate venostasis; near the above mentioned vessels there are macrophages and microglia cells present (2).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4388018&req=5

fig8: Histological image of dentate gyrus in animals in group IP (enlargement 400x). Basically correct image of structure with clear marking of the net of capillary blood vessels (1); in the lumen of capillary vessel numerous erythrocytes forming rouleau are shown, whose presence may indicate venostasis; near the above mentioned vessels there are macrophages and microglia cells present (2).
Mentions: In control group with induced pleuritis IP (Figure 8) main changes occurring in the area of dentate gyrus concern granular and pyramidal layer. To a smaller extent they apply to molecular layer. The nature of changes is like in the area of Ammon's horn but the degree of those changes is bigger particularly in the layer of pyramidal cells. In the layer of granular cells a bigger glial proliferation than in Ammon's horn can be observed. In the lumen of capillary vessels rouleau formation of erythrocytes is found which may prove hemostasis in blood vessels. Most clear changes of degenerative nature were observed in molecular layer.

Bottom Line: The aim of the study was to determine the effect of dioxins on function, ultrastructure, and cytological and histological structure of hippocampus, particularly on expression of estrogen receptors in central nervous system as well as to define protective influence of tocopherol (TCP) and acetylsalicylic acid (ASA) on the decrease in activity of proinflammatory effects in central nervous system.Histopathological and ultrastructural image of hippocampus areas in rats, in which both TCP and ASA were used, is characterized by poorly expressed degenerative changes and smaller inflammatory reactivity.Using both TCP and ASA has a protective effect on functions of central nervous system.

View Article: PubMed Central - PubMed

Affiliation: Department of Nervous System Diseases, The Faculty of Health Science, Wroclaw Medical University, Bartla 5 Street, 51-618 Wrocław, Poland.

ABSTRACT
The effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on central nervous system consists of changing expression of estrogen receptors, whereas the result of chronic inflammatory reaction caused by dioxin is occurrence of destructive changes in various organs connected with disturbed metabolism of connective tissue and damage of cells. The aim of the study was to determine the effect of dioxins on function, ultrastructure, and cytological and histological structure of hippocampus, particularly on expression of estrogen receptors in central nervous system as well as to define protective influence of tocopherol (TCP) and acetylsalicylic acid (ASA) on the decrease in activity of proinflammatory effects in central nervous system. It was shown that TCDD contributes to destructive and inflammatory changes along with demyelization of myelin sheaths and atrophy of estrogen receptors in hippocampus. Dioxin contributes to atrophy of estrogen receptors in hippocampus, in which also destructive and inflammatory changes were found along with demyelination of myelin sheaths. Histopathological and ultrastructural image of hippocampus areas in rats, in which both TCP and ASA were used, is characterized by poorly expressed degenerative changes and smaller inflammatory reactivity. Using both TCP and ASA has a protective effect on functions of central nervous system.

Show MeSH
Related in: MedlinePlus