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Histopathological, ultrastructural, and immunohistochemical assessment of hippocampus structures of rats exposed to TCDD and high doses of tocopherol and acetylsalicylic acid.

Rosińczuk J, Dymarek R, Całkosiński I - Biomed Res Int (2015)

Bottom Line: The aim of the study was to determine the effect of dioxins on function, ultrastructure, and cytological and histological structure of hippocampus, particularly on expression of estrogen receptors in central nervous system as well as to define protective influence of tocopherol (TCP) and acetylsalicylic acid (ASA) on the decrease in activity of proinflammatory effects in central nervous system.Histopathological and ultrastructural image of hippocampus areas in rats, in which both TCP and ASA were used, is characterized by poorly expressed degenerative changes and smaller inflammatory reactivity.Using both TCP and ASA has a protective effect on functions of central nervous system.

View Article: PubMed Central - PubMed

Affiliation: Department of Nervous System Diseases, The Faculty of Health Science, Wroclaw Medical University, Bartla 5 Street, 51-618 Wrocław, Poland.

ABSTRACT
The effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on central nervous system consists of changing expression of estrogen receptors, whereas the result of chronic inflammatory reaction caused by dioxin is occurrence of destructive changes in various organs connected with disturbed metabolism of connective tissue and damage of cells. The aim of the study was to determine the effect of dioxins on function, ultrastructure, and cytological and histological structure of hippocampus, particularly on expression of estrogen receptors in central nervous system as well as to define protective influence of tocopherol (TCP) and acetylsalicylic acid (ASA) on the decrease in activity of proinflammatory effects in central nervous system. It was shown that TCDD contributes to destructive and inflammatory changes along with demyelization of myelin sheaths and atrophy of estrogen receptors in hippocampus. Dioxin contributes to atrophy of estrogen receptors in hippocampus, in which also destructive and inflammatory changes were found along with demyelination of myelin sheaths. Histopathological and ultrastructural image of hippocampus areas in rats, in which both TCP and ASA were used, is characterized by poorly expressed degenerative changes and smaller inflammatory reactivity. Using both TCP and ASA has a protective effect on functions of central nervous system.

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Histological image of hippocampus in animals in group IPDE (enlargement 400x). In the analyzed material the decrease of intensity of neurodegradation changes in neurons is observed; in the lumen of capillary vessels, there are numerous erythrocytes visible in rouleau formation (1), which may indicate the presence of venostasis; the foam structure between neurons is more poorly expressed (2).
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fig4: Histological image of hippocampus in animals in group IPDE (enlargement 400x). In the analyzed material the decrease of intensity of neurodegradation changes in neurons is observed; in the lumen of capillary vessels, there are numerous erythrocytes visible in rouleau formation (1), which may indicate the presence of venostasis; the foam structure between neurons is more poorly expressed (2).

Mentions: In hippocampus in group IPDE (Figure 4) a smaller degree of damage of neurons occurs than in group IPD. The decrease of degenerative changes can be observed. It concerns all hippocampus zones of pyramidal cells as well as cells of granular and molecular layers. There is also a smaller degree of damage within blood vessels and glial proliferation is less intensified than in histopathological image in group IPD.


Histopathological, ultrastructural, and immunohistochemical assessment of hippocampus structures of rats exposed to TCDD and high doses of tocopherol and acetylsalicylic acid.

Rosińczuk J, Dymarek R, Całkosiński I - Biomed Res Int (2015)

Histological image of hippocampus in animals in group IPDE (enlargement 400x). In the analyzed material the decrease of intensity of neurodegradation changes in neurons is observed; in the lumen of capillary vessels, there are numerous erythrocytes visible in rouleau formation (1), which may indicate the presence of venostasis; the foam structure between neurons is more poorly expressed (2).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4388018&req=5

fig4: Histological image of hippocampus in animals in group IPDE (enlargement 400x). In the analyzed material the decrease of intensity of neurodegradation changes in neurons is observed; in the lumen of capillary vessels, there are numerous erythrocytes visible in rouleau formation (1), which may indicate the presence of venostasis; the foam structure between neurons is more poorly expressed (2).
Mentions: In hippocampus in group IPDE (Figure 4) a smaller degree of damage of neurons occurs than in group IPD. The decrease of degenerative changes can be observed. It concerns all hippocampus zones of pyramidal cells as well as cells of granular and molecular layers. There is also a smaller degree of damage within blood vessels and glial proliferation is less intensified than in histopathological image in group IPD.

Bottom Line: The aim of the study was to determine the effect of dioxins on function, ultrastructure, and cytological and histological structure of hippocampus, particularly on expression of estrogen receptors in central nervous system as well as to define protective influence of tocopherol (TCP) and acetylsalicylic acid (ASA) on the decrease in activity of proinflammatory effects in central nervous system.Histopathological and ultrastructural image of hippocampus areas in rats, in which both TCP and ASA were used, is characterized by poorly expressed degenerative changes and smaller inflammatory reactivity.Using both TCP and ASA has a protective effect on functions of central nervous system.

View Article: PubMed Central - PubMed

Affiliation: Department of Nervous System Diseases, The Faculty of Health Science, Wroclaw Medical University, Bartla 5 Street, 51-618 Wrocław, Poland.

ABSTRACT
The effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on central nervous system consists of changing expression of estrogen receptors, whereas the result of chronic inflammatory reaction caused by dioxin is occurrence of destructive changes in various organs connected with disturbed metabolism of connective tissue and damage of cells. The aim of the study was to determine the effect of dioxins on function, ultrastructure, and cytological and histological structure of hippocampus, particularly on expression of estrogen receptors in central nervous system as well as to define protective influence of tocopherol (TCP) and acetylsalicylic acid (ASA) on the decrease in activity of proinflammatory effects in central nervous system. It was shown that TCDD contributes to destructive and inflammatory changes along with demyelization of myelin sheaths and atrophy of estrogen receptors in hippocampus. Dioxin contributes to atrophy of estrogen receptors in hippocampus, in which also destructive and inflammatory changes were found along with demyelination of myelin sheaths. Histopathological and ultrastructural image of hippocampus areas in rats, in which both TCP and ASA were used, is characterized by poorly expressed degenerative changes and smaller inflammatory reactivity. Using both TCP and ASA has a protective effect on functions of central nervous system.

Show MeSH
Related in: MedlinePlus