Hypothetical exposure limits for oil-based metalworking fluids and cardiovascular mortality in a cohort of autoworkers: structural accelerated failure time models in a public health framework.
Bottom Line: Banning oil-based fluids would have saved an estimated 4,003 (95% confidence interval: 2,200, 5,807) life-years among those who died of ischemic heart disease.Estimates for cardiovascular disease overall, acute myocardial infarction, and cerebrovascular disease were 3,500 (95% confidence interval: 1,350, 5,651), 2,932 (95% confidence interval: 1,587, 4,277), and 917 (95% confidence interval: -80, 1,913) life-years, respectively.A limit of 0.01 mg/m(3) would have had a similar impact on cerebrovascular disease but one only half as great on ischemic heart disease.
Related in: MedlinePlus
Mentions: Figure 4 shows the estimated effects on cerebrovascular mortality. Here, the shape of the curve is different from the shape for the other outcomes. A ban is estimated not to provide substantially more benefit for this outcome than a limit of 0.02 mg/m3, whereas a smaller impact was estimated for a limit of 0.03 mg/m3. For higher exposure limits, the estimated effects drop down to . Figure 5 shows the estimated effects on all-cause mortality. These larger impacts had narrower confidence intervals.Figure 4.