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Comparative analysis of anterior segment parameters in normal and keratoconus eyes generated by scheimpflug tomography.

Orucoglu F, Toker E - J Ophthalmol (2015)

Bottom Line: Receiver operating characteristic curve analyses showed excellent predictive accuracy (area under the curve, ranging from 0.914 to 0.972) for 21 of the 40 parameters evaluated.Conclusions.Parameters derived from the topometric and Belin-Ambrósio enhanced ectasia display maps very effectively discriminate keratoconus from normal corneas with excellent sensitivity and specificity.

View Article: PubMed Central - PubMed

Affiliation: Birinci Eye Hospital, 34520 Istanbul, Turkey.

ABSTRACT
Purpose. To assess and compare the anterior and posterior corneal surface parameters, keratoconus indices, thickness profile data, and data from enhanced elevation maps of keratoconic and normal corneas with the Pentacam Scheimpflug corneal tomography and to determine the sensitivity and specificity of these parameters in discriminating keratoconus from normal eyes. Methods. The study included 656 keratoconus eyes and 515 healthy eyes with a mean age of 30.95 ± 9.25 and 32.90 ± 14.78 years, respectively. Forty parameters obtained from the Pentacam tomography were assessed by the receiver operating characteristic curve analysis for their efficiency. Results. Receiver operating characteristic curve analyses showed excellent predictive accuracy (area under the curve, ranging from 0.914 to 0.972) for 21 of the 40 parameters evaluated. Among all parameters indices of vertical asymmetry, keratoconus index, front elevation at thinnest location, back elevation at thinnest location, Ambrósio Relational Thickness (ARTmax), deviation of average pachymetric progression, deviation of ARTmax, and total deviation showed excellent (>90%) sensitivity and specificity in addition to excellent area under the receiver operating characteristic curve (AUROC). Conclusions. Parameters derived from the topometric and Belin-Ambrósio enhanced ectasia display maps very effectively discriminate keratoconus from normal corneas with excellent sensitivity and specificity.

No MeSH data available.


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(a) Topographic, (b) topometric, and (c) Belin-Ambrósio enhanced ectasia display maps of the Pentacam.
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fig1: (a) Topographic, (b) topometric, and (c) Belin-Ambrósio enhanced ectasia display maps of the Pentacam.

Mentions: Parameters were derived from topographic, topometric, and BAD maps (Figures 1(a), 1(b), and 1(c)). Parameters of the printout retained for the analysis were keratometry readings, topographic astigmatism and asphericity for the anterior and posterior corneal surface, pachymetry, cornea volume, and anterior chamber volume, angle, and depth, topometric indices, data from corneal thickness spatial profiles, and Belin-Ambrósio enhanced ectasia display. The abbreviations for these parameters are used in this paper and they are explained in Abbreviations.


Comparative analysis of anterior segment parameters in normal and keratoconus eyes generated by scheimpflug tomography.

Orucoglu F, Toker E - J Ophthalmol (2015)

(a) Topographic, (b) topometric, and (c) Belin-Ambrósio enhanced ectasia display maps of the Pentacam.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4388013&req=5

fig1: (a) Topographic, (b) topometric, and (c) Belin-Ambrósio enhanced ectasia display maps of the Pentacam.
Mentions: Parameters were derived from topographic, topometric, and BAD maps (Figures 1(a), 1(b), and 1(c)). Parameters of the printout retained for the analysis were keratometry readings, topographic astigmatism and asphericity for the anterior and posterior corneal surface, pachymetry, cornea volume, and anterior chamber volume, angle, and depth, topometric indices, data from corneal thickness spatial profiles, and Belin-Ambrósio enhanced ectasia display. The abbreviations for these parameters are used in this paper and they are explained in Abbreviations.

Bottom Line: Receiver operating characteristic curve analyses showed excellent predictive accuracy (area under the curve, ranging from 0.914 to 0.972) for 21 of the 40 parameters evaluated.Conclusions.Parameters derived from the topometric and Belin-Ambrósio enhanced ectasia display maps very effectively discriminate keratoconus from normal corneas with excellent sensitivity and specificity.

View Article: PubMed Central - PubMed

Affiliation: Birinci Eye Hospital, 34520 Istanbul, Turkey.

ABSTRACT
Purpose. To assess and compare the anterior and posterior corneal surface parameters, keratoconus indices, thickness profile data, and data from enhanced elevation maps of keratoconic and normal corneas with the Pentacam Scheimpflug corneal tomography and to determine the sensitivity and specificity of these parameters in discriminating keratoconus from normal eyes. Methods. The study included 656 keratoconus eyes and 515 healthy eyes with a mean age of 30.95 ± 9.25 and 32.90 ± 14.78 years, respectively. Forty parameters obtained from the Pentacam tomography were assessed by the receiver operating characteristic curve analysis for their efficiency. Results. Receiver operating characteristic curve analyses showed excellent predictive accuracy (area under the curve, ranging from 0.914 to 0.972) for 21 of the 40 parameters evaluated. Among all parameters indices of vertical asymmetry, keratoconus index, front elevation at thinnest location, back elevation at thinnest location, Ambrósio Relational Thickness (ARTmax), deviation of average pachymetric progression, deviation of ARTmax, and total deviation showed excellent (>90%) sensitivity and specificity in addition to excellent area under the receiver operating characteristic curve (AUROC). Conclusions. Parameters derived from the topometric and Belin-Ambrósio enhanced ectasia display maps very effectively discriminate keratoconus from normal corneas with excellent sensitivity and specificity.

No MeSH data available.


Related in: MedlinePlus