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Serum ferritin has correlation with HbA1c in type 2 diabetic patients.

Momeni A, Behradmanesh MS, Kheiri S, Abasi F - Adv Biomed Res (2015)

Bottom Line: Serum C-reactive protein (CRP) and ferritin are two acute phase reactants.The mean age of the patients was 56.5 ± 9.7 (30 to 82) years.Based on our results, serum ferritin decreased after decline of patients' blood sugar, so might be we used it as one of the diabetes control indices for diabetic patients.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran.

ABSTRACT

Background: Serum C-reactive protein (CRP) and ferritin are two acute phase reactants. CRP may be related to metabolic syndrome and ferritin which in turn could cause resistance to insulin and dysfunction of b cells of pancreases. The aim of the study was the evaluation of the relationship of these two acute phase reactants with some indices of diabetic control.

Materials and methods: In a quasi-experimental study, 67 patients with type 2 diabetes, serum CRP, ferritin, Fasting Blood Sugar (FBS), post prandial BS, Hemoglobin A1c (HbA1c), triglyceride, Low Density Lipoprotein Cholesterol (LDL) and High Density Lipoprotein cholesterol (HDL) were checked before and 3 months after the control of hyperglycemia and hyperlipidemia.

Results: The mean age of the patients was 56.5 ± 9.7 (30 to 82) years. There was no significant difference between CRP before and after study; however, serum ferritin significantly decreased after study with control of hyperglycemia. FBS, 2 hours post-prandial blood sugar (2hppBS), HbA1c and triglyceride of patients decreased significantly after control of hyperglycemia and hyperlipidemia (P < 0.05); however, HDL and LDL cholesterol didn't change (P > 0.05).

Conclusion: Based on our results, serum ferritin decreased after decline of patients' blood sugar, so might be we used it as one of the diabetes control indices for diabetic patients.

No MeSH data available.


Related in: MedlinePlus

Scatter plot of ferritin based on diabetic duration at the beginning of study
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Figure 1: Scatter plot of ferritin based on diabetic duration at the beginning of study

Mentions: Mean serum ferritin, before and after the control of hyperglycemia were 115 ± 109.4 ng/mL and 91.4 ± 61.9 ng/mL, respectively (normal range: Males: 23 to 336 ng/mL and Females: 11 to 306 ng/mL). There was no significant difference between CRP before and after the study; however, serum ferritin significantly decreased after 3 months follow-up, which means that serum ferritin would decrease with reducing serum FBS and post-prandial BS [Figures 1 and 2].


Serum ferritin has correlation with HbA1c in type 2 diabetic patients.

Momeni A, Behradmanesh MS, Kheiri S, Abasi F - Adv Biomed Res (2015)

Scatter plot of ferritin based on diabetic duration at the beginning of study
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4386204&req=5

Figure 1: Scatter plot of ferritin based on diabetic duration at the beginning of study
Mentions: Mean serum ferritin, before and after the control of hyperglycemia were 115 ± 109.4 ng/mL and 91.4 ± 61.9 ng/mL, respectively (normal range: Males: 23 to 336 ng/mL and Females: 11 to 306 ng/mL). There was no significant difference between CRP before and after the study; however, serum ferritin significantly decreased after 3 months follow-up, which means that serum ferritin would decrease with reducing serum FBS and post-prandial BS [Figures 1 and 2].

Bottom Line: Serum C-reactive protein (CRP) and ferritin are two acute phase reactants.The mean age of the patients was 56.5 ± 9.7 (30 to 82) years.Based on our results, serum ferritin decreased after decline of patients' blood sugar, so might be we used it as one of the diabetes control indices for diabetic patients.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran.

ABSTRACT

Background: Serum C-reactive protein (CRP) and ferritin are two acute phase reactants. CRP may be related to metabolic syndrome and ferritin which in turn could cause resistance to insulin and dysfunction of b cells of pancreases. The aim of the study was the evaluation of the relationship of these two acute phase reactants with some indices of diabetic control.

Materials and methods: In a quasi-experimental study, 67 patients with type 2 diabetes, serum CRP, ferritin, Fasting Blood Sugar (FBS), post prandial BS, Hemoglobin A1c (HbA1c), triglyceride, Low Density Lipoprotein Cholesterol (LDL) and High Density Lipoprotein cholesterol (HDL) were checked before and 3 months after the control of hyperglycemia and hyperlipidemia.

Results: The mean age of the patients was 56.5 ± 9.7 (30 to 82) years. There was no significant difference between CRP before and after study; however, serum ferritin significantly decreased after study with control of hyperglycemia. FBS, 2 hours post-prandial blood sugar (2hppBS), HbA1c and triglyceride of patients decreased significantly after control of hyperglycemia and hyperlipidemia (P < 0.05); however, HDL and LDL cholesterol didn't change (P > 0.05).

Conclusion: Based on our results, serum ferritin decreased after decline of patients' blood sugar, so might be we used it as one of the diabetes control indices for diabetic patients.

No MeSH data available.


Related in: MedlinePlus